2.3.1.57: diamine N-acetyltransferase
This is an abbreviated version!
For detailed information about diamine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.57
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2.3.1.57
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polyamine
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ornithine
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s-adenosylmethionine
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n1-acetylspermidine
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denspm
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pao
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n1,n11-diethylnorspermine
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n1,n12-bisethylspermine
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alpha-difluoromethylornithine
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analysis
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superinduction
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antizyme
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drug development
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malme-3m
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n1-acetylation
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gcn5-related
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pharmacology
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bisguanylhydrazone
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medicine
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adometdc
- 2.3.1.57
- polyamine
- ornithine
- s-adenosylmethionine
- n1-acetylspermidine
-
denspm
- pao
- n1,n11-diethylnorspermine
- n1,n12-bisethylspermine
- alpha-difluoromethylornithine
- analysis
-
superinduction
- antizyme
- drug development
-
malme-3m
-
n1-acetylation
-
gcn5-related
- pharmacology
-
bisguanylhydrazone
- medicine
- adometdc
Reaction
Synonyms
acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, acetyltransferase, putrescine, bltD, CpSSAT, diamine acetyltransferase, More, N1-SAT, N1-spermidine/spermine acetyltransferase, N1SSAT, PaiA, putrescine (diamine)-acetylating enzyme, putrescine acetylase, putrescine acetyltransferase, putrescine N-acetyltransferase, SAT, SAT1, SpeG, spermidine /spermine N1-acetyltransferase, spermidine acetyltransferase, spermidine N-acetyltransferase, spermidine N1-acetyltransferase, spermidine-spermine acetyltransferase, spermidine-spermine N1-acetyltransferase, spermidine/spermine acetyltransferase, spermidine/spermine N-acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine/spermine N1-acetyltransferase 1, spermidine/spermine N1-acetyltransferase 2, spermidine/spermine N1-acetyltransferase-1, spermidine/spermine-N 1-acetyltransferase, spermidine/spermine-N1-acetyltransferase, spermidine/spermine-N1-acetyltransferase activity, SSAT, SSAT-1, SSAT-2, SSAT1, SSAT2, SSATX, Ste27, Ta0374, VCA0947
ECTree
2.3.1.57 diamine N-acetyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.57 - diamine N-acetyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + eIF5A
CoA + acytyl-eIF5A
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selective acetylation of the hypusine and/or deoxyhypusine residue of translation initiation factor eIF5A, resulting in loss of eIF5A activity. Hypusine or deoxyhypusine, as the free amino acid, do not act as a substrate for isoform SSAT1
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?
acetyl-CoA + putrescine
CoA + acetylputrescine
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breakdown of spermidine and putrescine
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?
3 acetyl-CoA + 2 spermine
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
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-
-
?
3 acetyl-CoA + 2 spermine
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
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-
-
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?
3 acetyl-CoA + 2 spermine
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
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-
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?
3 acetyl-CoA + 2 spermine
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
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-
-
-
?
3 acetyl-CoA + 2 spermine
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
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-
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?
3 acetyl-CoA + 2 spermine
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
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-
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?
3 acetyl-CoA + 2 spermine
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
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-
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?
3 acetyl-CoA + 2 spermine
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
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-
-
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?
3 acetyl-CoA + 2 spermine
3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
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-
-
?
3 acetyl-CoA + spermidine
3 CoA + N1,N4,N8-triacetylspermidine
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-
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?
3 acetyl-CoA + spermidine
3 CoA + N1,N4,N8-triacetylspermidine
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-
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?
3 acetyl-CoA + spermidine
3 CoA + N1,N4,N8-triacetylspermidine
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-
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?
3 acetyl-CoA + spermidine
3 CoA + N1,N4,N8-triacetylspermidine
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-
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?
acetyl-CoA + 1,12-diamino-3,6,9-triazadodecane
?
an extremely poor substrate of human recombinant SSAT2, that is metabolized by SSAT1 in Hep-G2 cells and in wild-type primary hepatocytes
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-
?
acetyl-CoA + 1,12-diamino-3,6,9-triazadodecane
?
SSAT1 is the main acetylator of 1,12-diamino-3,6,9-triazadodecane compared to SSAT2
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-
?
acetyl-CoA + amantadine
CoA + N1-acetylamantadine
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reaction occurs in vivo and in vitro, but only in presence of increased enzyme levels, amantadine may be a specific drug substrate for SSAT
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?
acetyl-CoA + norspermidine
CoA + N1-acetylnorspermidine
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-
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?
acetyl-CoA + norspermidine
CoA + N1-acetylnorspermidine
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-
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?
acetyl-CoA + spermidine
CoA + N1-acetylspermidine
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-
-
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?
acetyl-CoA + spermidine
CoA + N1-acetylspermidine
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spermidine acetylation might be a strategy for inhibiting growth in response to environmental stresses
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?
acetyl-CoA + spermidine
CoA + N1-acetylspermidine
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catabolism of spermidine and spermine
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?
acetyl-CoA + spermidine
CoA + N1-acetylspermidine
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catabolism of spermidine and spermine
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?
acetyl-CoA + spermidine
CoA + N1-acetylspermidine
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spermidine and spermine may be physiological substrates, enzyme may play an important role in interconversion of polyamines
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-
?
acetyl-CoA + spermidine
CoA + N1-acetylspermidine
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-
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?
acetyl-CoA + spermidine
CoA + N1-acetylspermidine
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breakdown of spermidine and putrescine, key agent in the supply of nitrogen to the cell
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-
?
acetyl-CoA + spermidine
CoA + N1-acetylspermidine
[Candida] boidinii CBS 5777
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breakdown of spermidine and putrescine, key agent in the supply of nitrogen to the cell
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-
?
acetyl-CoA + spermine
CoA + N1-acetylspermine
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-
-
?
acetyl-CoA + spermine
CoA + N1-acetylspermine
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-
-
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?
acetyl-CoA + spermine
CoA + N1-acetylspermine
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catabolism of spermidine and spermine
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-
?
acetyl-CoA + spermine
CoA + N1-acetylspermine
N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) crucial for regulation of the cellular polyamine levels in eukaryotic cells
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-
?
acetyl-CoA + spermine
CoA + N1-acetylspermine
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spermidine and spermine may be physiological substrates, enzyme may play an important role in interconversion of polyamines
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?
acetyl-CoA + spermine
CoA + N1-acetylspermine
preferred substrate
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?
acetyl-CoA + spermine
CoA + N1-acetylspermine
preferred substrate
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-
?
acetyl-CoA + triethylenetetramine
?
SSAT2 is the main acetylator of TETA compared to SSAT1
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?
acetyl-CoA + triethylenetetramine
?
SSAT2 is the main acetylator of TETA compared to SSAT1
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?
additional information
?
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enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations
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?
additional information
?
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important function in the degradation of diamines of lower eukaryotes
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?
additional information
?
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acetylation is a physiological response to convert excess polyamines to a physiologically inert form which is readily excreted
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?
additional information
?
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enzyme plays an efficient role in maintaining polyamine pool homeostasis during challenges with exogenous polyamines
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?
additional information
?
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rate-limiting enzyme in the degradation and interconversion of polyamines
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?
additional information
?
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SSAT prevents overaccumulation of higher polyamines from becoming toxic to cell and maintains a balanced ratio of polyamines according to cellular needs
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?
additional information
?
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isozyme SSAT-2 shows very low activity in intact wild-type cells, but is equally active to isozyme SSAT-1 in recombinantly transfected cells
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?
additional information
?
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isozyme SSAT-2 shows very low activity in intact wild-type cells, but is equally active to isozyme SSAT-1 in recombinantly transfected cells
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?
additional information
?
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isozyme SSAT-2 shows very low activity in intact wild-type cells, but is equally active to isozyme SSAT-1 in recombinantly transfected cells
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?
additional information
?
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the enzyme functions as a coactivator for NF-kappaB and cooperates with CREB-binding protein and the p300/CBP-associated factor to enhance NF-kappaB-dependent transcription
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?
additional information
?
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N1,N11-diethylnorspermine induces apoptosis involving increased SSAT activity and the mitochondria of the cell
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?
additional information
?
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simultaneous drug combination or quinoxaline pre-treatment synergistically increases SSAT expression, depletes polyamines, increases reactive oxygen species production, and produces synergistic tumor cell killing in both cell lines, overview. Cisplatin-resistant human ovarian cell line, A2780/CP cells, cannot be induced by spermidine analogues, in contrast to the sensitive counterpart A2780
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?
additional information
?
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SSAT binds to the HIF-1alpha subunit and promotes its ubiquitination and degradation. SSAT transcriptional regulation, regulation of SSAT protein levels by polyamines or analogues, SSAT protein turnover, overview. Upregulation of the Sat1 gene transcription is critical for the cell-specific polyamine or analog-mediated increase in SSAT content
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?
additional information
?
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SSAT expression causes arrest of cell cycle and cell growth in the S-phase in transfected cells through a mechanism involving the suppression of cyclin A and E2F1-expression, overview
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?
additional information
?
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SSAT induction increased metabolic flux by about 5fold, overview. The metabolic flux can be interrupted by inhibition of polyamine biosynthesis but not by inhibition of polyamine oxidation
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?
additional information
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the enzyme transforms polyamines into putrescine
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?
additional information
?
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the enzyme transforms polyamines into putrescine
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?
additional information
?
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SSAT catalyzes together with polyamine oxidase the back-conversion of spermine to spermidine and the latter to putrescine, a function lowering polyamine pools by facilitating their catabolism and excretion
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?
additional information
?
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enzyme plays an efficient role in maintaining polyamine pool homeostasis during challenges with exogenous polyamines
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?
additional information
?
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the enzyme is involved in intestinal tumorigenesis in ApcMin/+ MIN mice, enzyme is involved in catabolism of polyamines, activation of the enzyme in vivo results in suppression of tumor outgrowth in a mouse prostate cancer model
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?
additional information
?
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the enzyme is rate-limiting in polyamine catabolism
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?
additional information
?
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participates in polyamine homeostasis by regulating polyamine export and catabolism. Expression status of spermidine/spermine N1-acetyltransferase alters body fat accumulation by metabolically modulating tissue acetyl- and malonyl-CoA levels, thereby influencing fatty acid biosynthesis and oxidation
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?
additional information
?
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SSAT gene expression is fine-tuned by regulated unproductive splicing and translation, which is modulated by polyamine levels
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?
additional information
?
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regulation of SSAT protein levels by polyamines or analogues, overview
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?
additional information
?
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SSAT catalyzes the transfer of acetyl groups from acetylcoenzyme A to spermidine and spermine, as part of a polyamine degradation pathway. No activity with putrescine, cadaverine, lysine, thialysine, amantadine, substrate specificity, overview
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?
additional information
?
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enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations
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?
additional information
?
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regulation of SSAT protein levels by polyamines or analogues, overview
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?
