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0.106
1,12-diamino-3,6,9-triazadodecane
pH and temperature not specified in the publication
0.107 - 1.25
1,3-diaminopropane
0.1 - 0.44
1,5-Diaminopentane
0.4
1,6-diaminohexane
-
-
1.59
1,7-Diaminoheptane
-
-
0.012
15-deoxyspergualin
-
-
0.0015 - 0.056
acetyl-CoA
0.41
aminopropylcadaverine
-
pH 9
0.215
D-glucosamine 6-phosphate
pH 8.0, 30°C
0.194
diethylenetriamine
measured at fixed saturating concentrations of acetyl-CoA
0.196
ethylenediamine
measured at fixed saturating concentrations of acetyl-CoA
4.4
N1-acetylspermidine
-
-
0.03 - 0.295
N1-acetylspermine
0.01
N1-dansylnorspermine
-
pH 7.8, 37°C, SSAT in hepatoma cells
0.018
N1-dansylspermine
-
pH 7.8, 37°C, SSAT in hepatoma cells
1.4
N8-Acetylspermidine
-
-
0.859
poly-L-lysine
pH 8.0, 30°C
0.008 - 0.5
sym-norspermidine
0.083
triethylenetetramine
pH and temperature not specified in the publication
additional information
additional information
-
0.107
1,3-diaminopropane
measured at fixed saturating concentrations of acetyl-CoA
0.27
1,3-diaminopropane
-
-
1.25
1,3-diaminopropane
-
-
0.1
1,5-Diaminopentane
-
-
0.44
1,5-Diaminopentane
-
-
0.0015
acetyl-CoA
-
-
0.0038
acetyl-CoA
measured at fixed saturating concentration of spermidine
0.013
acetyl-CoA
-
pH 7.8, 37°C, SSAT in hepatoma cells
0.014
acetyl-CoA
-
putrescine as cosubstrate
0.056
acetyl-CoA
pH 8.0, 30°C
0.03
N1-acetylspermine
-
-
0.295
N1-acetylspermine
-
pH 9
0.25
putrescine
-
-
0.26 - 0.44
putrescine
-
-
0.022
spermidine
measured at fixed saturating concentrations of acetyl-CoA
0.026
spermidine
-
pH 7.8, 37°C, SSAT in hepatoma cells
0.05
spermidine
-
wild-type enzyme
0.055
spermidine
pH 7.5, 25°C
0.056
spermidine
-
pH 7.8, 30°C, recombinant wild-type enzyme
0.065
spermidine
pH 8.0, 30°C
0.09
spermidine
isozyme ssat1b, pH and temperature not specified in the publication
0.182
spermidine
isozyme ssat1a, pH and temperature not specified in the publication
0.232
spermidine
isozyme ssat1c, pH and temperature not specified in the publication
0.3
spermidine
-
pH 7.8, 30°C, recombinant mutant L156F enzyme
0.39
spermidine
-
K141R mutant
0.769
spermidine
-
at pH 7.5 and 30°C
1.33
spermidine
at pH 7.5 and 30°C
0.0037
spermine
-
pH 7.8, 30°C, recombinant wild-type enzyme
0.0057
spermine
measured at fixed saturating concentrations of acetyl-CoA
0.037
spermine
-
pH 7.8, 30°C, recombinant mutant L156F enzyme
0.045
spermine
-
at pH 7.5 and 30°C
0.055
spermine
isozyme ssat1a, pH and temperature not specified in the publication
0.091
spermine
isozyme ssat1b, pH and temperature not specified in the publication
0.139
spermine
isozyme ssat1c, pH and temperature not specified in the publication
0.182
spermine
pH 7.5, 25°C
0.295
spermine
at pH 7.5 and 30°C
0.338
spermine
pH 8.0, 30°C
0.008
sym-norspermidine
-
-
0.015
sym-norspermidine
-
pH 7.8, 37°C, SSAT in hepatoma cells
0.5
sym-norspermidine
-
-
additional information
additional information
no detectable activity for putrescine and cadaverine
-
additional information
additional information
-
no detectable activity for putrescine and cadaverine
-
additional information
additional information
-
Km value for spermine is lower than that for N1-acetylspermine
-
additional information
additional information
allosteric substrate binding, bireactant random steady-state kinetic mechanism
-
additional information
additional information
-
allosteric substrate binding, bireactant random steady-state kinetic mechanism
-
additional information
additional information
allosteric substrate binding, polyamine allosteric site structure, complex enzyme behavior, it exhibits sigmoidal curves and substrate inhibition, bireactant random steady-state kinetic mechanism, detailed non-linear regression kinetic analysis, overview
-
additional information
additional information
-
allosteric substrate binding, polyamine allosteric site structure, complex enzyme behavior, it exhibits sigmoidal curves and substrate inhibition, bireactant random steady-state kinetic mechanism, detailed non-linear regression kinetic analysis, overview
-