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2.3.1.57: diamine N-acetyltransferase

This is an abbreviated version!
For detailed information about diamine N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.57

Reaction

acetyl-CoA
+
an alkane-alpha,omega-diamine
=
CoA
+
an N-acetyldiamine

Synonyms

acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, acetyltransferase, putrescine, bltD, CpSSAT, diamine acetyltransferase, More, N1-SAT, N1-spermidine/spermine acetyltransferase, N1SSAT, PaiA, putrescine (diamine)-acetylating enzyme, putrescine acetylase, putrescine acetyltransferase, putrescine N-acetyltransferase, SAT, SAT1, SpeG, spermidine /spermine N1-acetyltransferase, spermidine acetyltransferase, spermidine N-acetyltransferase, spermidine N1-acetyltransferase, spermidine-spermine acetyltransferase, spermidine-spermine N1-acetyltransferase, spermidine/spermine acetyltransferase, spermidine/spermine N-acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine/spermine N1-acetyltransferase 1, spermidine/spermine N1-acetyltransferase 2, spermidine/spermine N1-acetyltransferase-1, spermidine/spermine-N 1-acetyltransferase, spermidine/spermine-N1-acetyltransferase, spermidine/spermine-N1-acetyltransferase activity, SSAT, SSAT-1, SSAT-2, SSAT1, SSAT2, SSATX, Ste27, Ta0374, VCA0947

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.57 diamine N-acetyltransferase

Inhibitors

Inhibitors on EC 2.3.1.57 - diamine N-acetyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3'-dephospho-CoA
-
less inhibition than by CoA
6,6-difluorospermidine
-
weak inhibition
acetyl-CoA
-
at high concentrations slight inhibition
amantadine
-
competitively inhibits spermidine acetylation, at 10 mM: complete inhibition
Berenil
Butan-2,3-dione
-
at 10 mM, in presence of borate buffer pH 9.0
CoA
-
strong inhibitor
CoA methyl disulfide
-
very strong inhibitor
diminazene aceturate
inhibitor of SSAT-1, does not induce apoptosis
hexamethylenediamine
-
30% inhibition
mescaline
-
-
N-acetylputrescine
-
slight, competitive inhibition
N-ethylmaleimide
-
-
N1,N11-bis-(ethyl)-norspermine
-
-
N1-spermine-acetyl-CoA
bisubstrate analogue, bisubstrate inhibition patterns determined, linear, competitive inhibition against sperimidine and acetyl-CoA determined
O-(11-amino-3,8-diaza-1-undecyl)oxime S-(2-oxopropyl)-CoA
-
O-(11-amino-3,8-diaza-1-undecyl)oxime S-(2-oxopropyl)-D-pantetheine
-
-
O-(6-amino-3-aza-1-hexyl)oxime S-(2-oxopropyl)-CoA
-
O-(6-amino-3-aza-1-hexyl)oxime S-(2-oxopropyl)-D-pantetheine
-
-
O-(7-amino-3-aza-1-heptyl)oxime S-(2-oxopropyl)-CoA
-
O-(7-amino-3-aza-1-heptyl)oxime S-(2-oxopropyl)-D-pantetheine
-
-
O-(7-amino-4-aza-1-heptyl)oxime S-(2-oxopropyl)-CoA
-
O-(7-amino-4-aza-1-heptyl)oxime S-(2-oxopropyl)-D-pantetheine
-
-
p-chloromercuribenzoate
pentamethylenediamine
-
30% inhibition
Pentamidine
Phenylglyoxal
-
at 10 mM, in bicarbonate buffer, pH 9.0
S-(2-oxopropyl)-CoA
-
S-(2-oxopropyl)-D-pantetheine
-
-
spermidine
0.005 mM, strong inhibition of eIF5A acetylation
spermine
sulfamethazine
-
inhibits spermidine acetylation
additional information
-