2.3.1.57: diamine N-acetyltransferase
This is an abbreviated version!
For detailed information about diamine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.57
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2.3.1.57
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polyamine
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ornithine
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s-adenosylmethionine
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n1-acetylspermidine
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denspm
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pao
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n1,n11-diethylnorspermine
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n1,n12-bisethylspermine
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alpha-difluoromethylornithine
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analysis
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superinduction
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antizyme
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drug development
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malme-3m
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n1-acetylation
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gcn5-related
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pharmacology
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bisguanylhydrazone
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medicine
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adometdc
- 2.3.1.57
- polyamine
- ornithine
- s-adenosylmethionine
- n1-acetylspermidine
-
denspm
- pao
- n1,n11-diethylnorspermine
- n1,n12-bisethylspermine
- alpha-difluoromethylornithine
- analysis
-
superinduction
- antizyme
- drug development
-
malme-3m
-
n1-acetylation
-
gcn5-related
- pharmacology
-
bisguanylhydrazone
- medicine
- adometdc
Reaction
Synonyms
acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, acetyltransferase, putrescine, bltD, CpSSAT, diamine acetyltransferase, More, N1-SAT, N1-spermidine/spermine acetyltransferase, N1SSAT, PaiA, putrescine (diamine)-acetylating enzyme, putrescine acetylase, putrescine acetyltransferase, putrescine N-acetyltransferase, SAT, SAT1, SpeG, spermidine /spermine N1-acetyltransferase, spermidine acetyltransferase, spermidine N-acetyltransferase, spermidine N1-acetyltransferase, spermidine-spermine acetyltransferase, spermidine-spermine N1-acetyltransferase, spermidine/spermine acetyltransferase, spermidine/spermine N-acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine/spermine N1-acetyltransferase 1, spermidine/spermine N1-acetyltransferase 2, spermidine/spermine N1-acetyltransferase-1, spermidine/spermine-N 1-acetyltransferase, spermidine/spermine-N1-acetyltransferase, spermidine/spermine-N1-acetyltransferase activity, SSAT, SSAT-1, SSAT-2, SSAT1, SSAT2, SSATX, Ste27, Ta0374, VCA0947
ECTree
2.3.1.57 diamine N-acetyltransferaseAdvanced search results
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Application on EC 2.3.1.57 - diamine N-acetyltransferase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
analysis
colorimetric assay for monitoring enzyme SSAT1 activity in zebrafish using a 412-nm absorption spectrum in the presence of Ellman's reagent. The method is cost-effective and simple and also applicable to detect the cellular enzyme activity
drug development
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SSAT may also be a useful target in diseases other than cancer
medicine
pharmacology
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compounds capable of potently inducing SSAT and having favorable pharmacological properties in animals are potential anticancer agents
medicine
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induction of enzyme may be critical for the inhibition of tumor cell growth
medicine
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development of SSAT induction strategies to circumvent the ability of tumor cells to escape the antitumor activity of polyamine inhibitors such as alpha-difluoromethylornithine by salvaging exogenous polyamines
medicine
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the ability of polyamine analogues to induce N1SSAT activity correlates with the ability to inhibit growth and viability of human tumor-derived cells
medicine
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activation of the enzyme by aspirin and different non-steroidal anti-inflammatory drugs may be a common property of non-steroidal anti-inflammatory drugs that plays an important role in their chemopreventive actions in colorectal cancer
medicine
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in kidneys subjected to ischemia-reperfusion injury, one mechanism through which increased expression of SSAT may cause cellular injury and organ damage is through induction of DNA damage and the disruption of cell cycle
medicine
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the enzyme may be an important target for therapeutic intervention in colorectal cancer
medicine
tumor progression in transgenic mouse lines overexpressing SSAT protein and susceptibility to skin carcinogenesis analyzed
medicine
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treatment of human C-28/I2 chondrocytes with polyamine analogue N1,N11-diethylnorspermine rapidly induces spermidine/spermine N1-acetyltransferase and spermine oxidase activities, and down-regulates ornithine decarboxylase. The treatment does not provoke cell death and caspase activation when given alone for 24 h, but causes a caspase-3 and -9 dependent apoptosis in chondrocytes further exposed to cycloheximide. The simultaneous addition of N1,N11-diethylnorspermine and cycloheximide rapidly increases caspase activity in C-28/I2 cells in the absence of spermidine/spermineN1-acetyltransferase and spermine oxidase induction or significant reduction of polyamine levels. Caspase activation induced by N1,N11-diethylnorspermine plus cycloheximide is not prevented by a N1-acetylpolyamine oxidase inhibitor
medicine
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compared with wild-typet mice, the enzyme-deficient mice subjected to endotoxic acute kidney injury have less severe kidney damage as indicated by better preservation of kidney function. Animals treated with MDL72527, an inhibitor of both polyamine oxidase and spermine oxidase, show significant protection against endotoxin-induced acute kidney injury. Increased polyamine catabolism may contribute to kidney damage through generation of by-products of polyamine oxidation
medicine
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amantadine can be used to determine enzyme cellular activity by measuring excretion of N1-acetylamantadine which may indicate the presence of cancer
medicine
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the enzyme is a veritable therapeutic target in glioblastoma that controls tumor cell stemness and aggressiveness. The enzyme promotes resistance to radiotherapy
