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2.3.1.51: 1-acylglycerol-3-phosphate O-acyltransferase

This is an abbreviated version!
For detailed information about 1-acylglycerol-3-phosphate O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.51

Reaction

acyl-CoA
+
1-acyl-sn-glycerol 3-phosphate
=
CoA
+
1,2-diacyl-sn-glycerol 3-phosphate

Synonyms

1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycero-3-phosphate acyltransferase 1, 1-acyl-sn-glycero-3-phosphate acyltransferase 9, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acyl-sn-glycerol-3-phosphate acyltransferas, 1-acyl-sn-glycerol-3-phosphate acyltransferase, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerol 3-phosphate O-acyltransferase, 1-acylglycerol-3-phosphate acyltransferase, 1-acylglycerol-3-phosphate-O-acyltransferase, 1-acylglycerol-3-phosphate-O-acyltransferase 2, 1-acylglycerol-3-phosphate-O-acyltransferase isoform10/glycerol-3-phosphate acyltransferase isoform 3, 1-acylglycerol-3-phosphate-O-acyltransferase-1, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, 1-Agpat2, ABHD5, acyl-CoA: sn-1-acyl-glycerol-3-phosphate acyltransferase, acyl-CoA:1-acylglycerol-sn-3-phosphate acyltransferase, acyl-CoA:lysophosphatidic acid acyltransferase, acyl-CoA:lysophospholipid acyltransferase, acyl-coenzyme A-dependent lysophosphatidic acid acyltransferase, acylglycerophosphate acyltransferase 4, acyltransferase, 1-acylglycerol phosphate, AGPAT, AGPAT/PlsC, AGPAT1, AGPAT10/GPAT3, AGPAT11, AGPAT2, AGPAT3, AGPAT4, AGPAT5, AGPAT6/GPAT4, AGPAT9, ALE1, At4g24160, AtLPAAt2, CGFI-58, cgi-58 protein, CGI-58/ABHD5, CHLREDRAFT_174358, coenzyme A-dependent lysophosphatidic acid, CrLPAAT1, CT775, CT_775, endoplasmic reticulum-located LPAT, ER-located LPAT, glycerol-3-phosphate acyltransferase-1, GPAT-1, ICT1 protein, LOA1, LPA acyltransferase, LPAAT, LPAAT-beta, LPAAT1, LPAAT2, LPAAT3, LPAAT4, LPAATbeta, LPAATdelta, LPAT, LPCAT1, LPCAT2, lysophosphatidic acid acyl transferase, lysophosphatidic acid acyltansferase, lysophosphatidic acid acyltransferase, lysophosphatidic acid acyltransferase 3, lysophosphatidic acid acyltransferase beta, lysophosphatidic acid ayltransferase, lysophosphatidic acid-acyltransferase, lysophosphatidic acid–specific acyltransferase, lysophosphatidyl acyltransferase, lysophosphatidyl acyltransferase 4, lysophosphatidylcholine acyltransferase 1, lysophospholipid acyltransferase, lysophospholipid:acyl-CoA acyltransferase, mAGPAT1, mAGPAT2, mAGPAT3, mAGPAT4, mAGPAT5, More, oleoyl-CoA lysophosphatidic acid acyltransferase, PCC8801_1274, plastidial LPAAT, plastidial lysophosphatidic acid acyltransferase, PlsC, PlsC4, PrLPAAT1, Scl1, ScLPAAT, SLC1, Slc1p, Slc4p, SlPlsC1, SMc00714 protein, SnGlycerol 3-P acyltransferase, TmPlsC, TM_1693, YPR139c

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase

Engineering

Engineering on EC 2.3.1.51 - 1-acylglycerol-3-phosphate O-acyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C247Y
loss of the ability of the plastidial enzyme to restore growth to JC201, suggests that C247 is essential for activity
D199A
the mutant fails to grow beyond 0.04 D600 after transfer to the non-permissive temperature. D199 is essential for the ability of the plastidial enzyme to complement the defective acyltransferase activity of JC201
E266A
the plastidial enzyme containing this mutation is unable to complement the temperature-sensitive phenotype of JC201, indicating an essential role for this acidic residue
G140S
loss of the ability of the plastidial enzyme to restore growth to JC201, suggests that G140 is essential for activity
H194A
the mutant fails to grow beyond 0.04 D600 after transfer to the non-permissive temperature. H194 is essential for the ability of the plastidial enzyme to complement the defective acyltransferase activity of JC201
K84Q
greatly impaired growth rate, possibly indicating an importance of the N-terminus of the mature protein in determining enzyme activity
L203P
loss of the ability of the plastidial enzyme to restore growth to JC201, suggests that L203 is essential for activity
P187L
loss of the ability of the plastidial enzyme to restore growth to JC201, suggests that P187 is essential for activity
R92G
greatly impaired growth rate, possibly indicating an importance of the N-terminus of the mature protein in determining enzyme activity
T122A
-
the change increases the substrate specificity in vitro for oleoyl-CoA and linoleoyl-CoA
T122L
-
the change increases the substrate specificity in vitro for lignoceroyl-CoA
140delF
-
34.8% of wild-type activity
221delGT
-
5% of wild-type activity
252delMRT
-
3.2% of wild-type activity
A239V
-
90% of wild-type activity
D168R
-
site-directed mutagenesis, the mutant shows slightly increased activity compared to the wild-type AGPAT8
D180fsX251
-
7.7% of wild-type activity
E260K
-
site-directed mutagenesis, mutation found in Chanarin-Dorfman syndrome patients, mutation without significant effect on acyltransferase activity
G136R
-
40.3% of wild-type activity
I208A
mutant of human AGPAT1
L228P
-
23.7% of wild-type activity
P207L
mutant of human AGPAT1
Q130P
-
site-directed mutagenesis, mutation found in Chanarin-Dorfman syndrome patients, mutation without significant effect on acyltransferase activity
R149K
mutant of human AGPAT1
R68X
-
14.2% of wild-type activity
T180S
mutant of human AGPAT1
V167fsX228
-
14.9% of wild-type activity
additional information