2.3.1.50: serine C-palmitoyltransferase
This is an abbreviated version!
For detailed information about serine C-palmitoyltransferase, go to the full flat file.
Word Map on EC 2.3.1.50
-
2.3.1.50
-
sphingolipids
-
ceramide
-
myriocin
-
sphingomyelin
-
sphingosine
-
sphingomyelinase
-
neuropathy
-
sphingoid
-
cholesterol
-
fumonisin
-
glucosylceramide
-
sphingosine-1-phosphate
-
3-ketodihydrosphingosine
-
corneum
-
glycosphingolipids
-
dihydroceramide
-
dihydrosphingosine
-
plp-dependent
-
l-cycloserine
-
ormdl3
-
molecular biology
-
sphingomonas
-
paucimobilis
-
transepidermal
-
charcot-marie-tooth
-
analysis
-
ceramide-induced
-
phytosphingosine
-
medicine
-
asmase
-
aldimine
- 2.3.1.50
- sphingolipids
- ceramide
- myriocin
- sphingomyelin
- sphingosine
- sphingomyelinase
- neuropathy
-
sphingoid
- cholesterol
- fumonisin
- glucosylceramide
- sphingosine-1-phosphate
- 3-ketodihydrosphingosine
- corneum
- glycosphingolipids
- dihydroceramide
- dihydrosphingosine
-
plp-dependent
- l-cycloserine
-
ormdl3
- molecular biology
- sphingomonas
- paucimobilis
-
transepidermal
-
charcot-marie-tooth
- analysis
-
ceramide-induced
- phytosphingosine
- medicine
- asmase
-
aldimine
Reaction
Synonyms
3-oxosphinganine synthetase, acyl-CoA:serine C-2 acyltransferase decarboxylating, LCB1, LCB2, LCB2a, LCB2b, More, palmitoyltransferase, serine, serine palmitoyl transferase, serine palmitoyltransferase, serine palmitoyltransferase 1, serine palmitoyltransferase a, serine-palmitoyl transferase, serine-palmitoyltransferase, SPT, SPT1, SPT2, SPT3, SPTase, SPTLC1, SPTLC2, ssSPT, ssSPTa, Tsc3
ECTree
2.3.1.50 serine C-palmitoyltransferaseAdvanced search results
results (
results (Reference
top
Reference on EC 2.3.1.50 - serine C-palmitoyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stoffel, W.; LeKim, D.; Sticht, G.
Biosynthesis of dihydrosphingosine in vitro
Hoppe-Seyler's Z. Physiol. Chem.
349
664-670
1968
Wickerhamomyces ciferrii, Rattus norvegicus
Merrill, A.H.; Wang, E.
Enzymes of ceramide biosynthesis
Methods Enzymol.
209
427-437
1992
Prevotella melaninogenica, Saccharomyces cerevisiae, Rattus norvegicus
Brady, R.N.; Di Mari, S.J.; Snell, E.E.
Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri
J. Biol. Chem.
244
491-496
1969
Wickerhamomyces ciferrii
Braun, P.E.; Snell, E.E.
The biosynthesis of dihydrosphingosine in cell-free preparations of Hansenula ciferri
Proc. Natl. Acad. Sci. USA
58
298-303
1967
Wickerhamomyces ciferrii
Holleran, W.M.; Williams, M.L.; Gao, W.N.; Elias, P.M.
Serine-palmitoyl transferase activity in cultured human keratinocytes
J. Lipid Res.
31
1655-1661
1990
Homo sapiens
Buede, R.; Rinker-Schaffer, C.; Pinto, W.J.; Lester, R.L.; Dickinson, R.C.
Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids [published erratum appears in J Bacteriol 1993 Feb;175(3):919]
J. Bacteriol.
173
4325-4332
1991
Saccharomyces cerevisiae
Lev, M.; Milford, A.F.
The 3-ketodihydrosphingosine synthetase of Bacteroides melaninogenicus: partial purification and properties
Arch. Biochem. Biophys.
212
424-431
1981
Prevotella melaninogenica
Merrill, A.H.; Williams, R.D.
Utilization of different fatty acyl-CoA thioesters by serine palmitoyltransferase from rat brain
J. Lipid Res.
25
185-188
1984
Rattus norvegicus
Williams, R.D.; Wang, E.; Merrill, A.H.
Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes
Arch. Biochem. Biophys.
228
282-291
1984
Rattus norvegicus
Medlock, K.A.; Merrill, A.H.
Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by beta-chloroalanine
Biochemistry
27
7079-7084
1988
Cricetulus griseus, Rattus norvegicus
Weiss, B.; Stoffel, W.
Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis
Eur. J. Biochem.
249
239-247
1997
Homo sapiens, Mus musculus
Garnepudi, V.R.; Zhao, C.; Beeler, T.; Dunn, T.
Serine palmitoyltransferase (scs1/lcb2) mutants have elevated copy number of the L-A dsRNA virus
Yeast
13
299-304
1997
Saccharomyces cerevisiae
Lynch, D.V.; Fairfield, S.R.
Sphingolipid long-chain base synthesis in plants. Characterization of serine palmitoyltransferase activity in squash fruit microsomes
Plant Physiol.
103
1421-1429
1993
Cucurbita pepo
Van Echten-Deckert, G.; Zschoche, A.; Bar, T.; Schmidt, R.R.; Raths, A.; Heinemann, T.; Sandhoff, K.
cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons
J. Biol. Chem.
272
15825-15833
1997
Mus musculus
Hanada, K.; Nishijima, M.; Fujita, T.; Kobayashi, S.
Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant
Biochem. Pharmacol.
59
1211-1216
2000
Cricetulus griseus
Gable, K.; Slife, H.; Bacikova, D.; Monaghan, E.; Dunn, T.M.
Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity
J. Biol. Chem.
275
7597-7603
2000
Saccharomyces cerevisiae
Ikushiro, H.; Hayashi, H.; Kagamiyama, H.
A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain: purification, characterization, cloning, and overproduction
J. Biol. Chem.
276
18249-18256
2001
Sphingomonas paucimobilis, Sphingomonas paucimobilis EY2395
Perry, D.K.; Carton, J.; Shah, A.K.; Meredith, F.; Uhlinger, D.J.; Hannun, Y.A.
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
J. Biol. Chem.
275
9078-9084
2000
Homo sapiens, Homo sapiens (O15269), Homo sapiens (O15270)
Perry, D.K.
Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses
Biochim. Biophys. Acta
1585
146-152
2002
Saccharomyces cerevisiae, Homo sapiens, Mus musculus
Ikushiro, H.; Hayashi, H.; Kagamiyama, H.
Bacterial serine palmitoyltransferase: a water-soluble homodimeric prototype of the eukaryotic enzyme
Biochim. Biophys. Acta
1647
116-120
2003
Sphingomonas paucimobilis (Q93UV0), Sphingomonas paucimobilis
Yasuda, S.; Nishijima, M.; Hanada, K.
Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells
J. Biol. Chem.
278
4176-4183
2003
Cricetulus griseus
Batheja, A.D.; Uhlinger, D.J.; Carton, J.M.; Ho, G.; D'Andrea, M.R.
Characterization of serine palmitoyltransferase in normal human tissues
J. Histochem. Cytochem.
51
687-696
2003
Homo sapiens (O15269), Homo sapiens (O15270), Homo sapiens
Lightle, S.; Tosheva, R.; Lee, A.; Queen-Baker, J.; Boyanovsky, B.; Shedlofsky, S.; Nikolova-Karakashian, M.
Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine-palmitoyl transferase
Arch. Biochem. Biophys.
419
120-128
2003
Homo sapiens, Mus musculus
Ikushiro, H.; Hayashi, H.; Kagamiyama, H.
Reactions of serine palmitoyltransferase with serine and molecular mechanisms of the actions of serine derivatives as inhibitors
Biochemistry
43
1082-1092
2004
Sphingomonas paucimobilis, Sphingomonas paucimobilis EY2395
Yamaji-Hasegawa, A.; Takahashi, A.; Tetsuka, Y.; Senoh, Y.; Kobayashi, T.
Fungal metabolite sulfamisterin suppresses sphingolipid synthesis through inhibition of serine palmitoyltransferase
Biochemistry
44
268-277
2005
Cricetulus griseus
Dedov, V.N.; Dedova, I.V.; Merrill, A.H., Jr.; Nicholson, G.A.
Activity of partially inhibited serine palmitoyltransferase is sufficient for normal sphingolipid metabolism and viability of HSN1 patient cells
Biochim. Biophys. Acta
1688
168-175
2004
Homo sapiens
Han, G.; Gable, K.; Yan, L.; Natarajan, M.; Krishnamurthy, J.; Gupta, S.D.; Borovitskaya, A.; Harmon, J.M.; Dunn, T.M.
The topology of the Lcb1p subunit of yeast serine palmitoyltransferase
J. Biol. Chem.
279
53707-53716
2004
Saccharomyces cerevisiae
Carton, J.M.; Uhlinger, D.J.; Batheja, A.D.; Derian, C.; Ho, G.; Argenteri, D.; D'Andrea, M.R.
Enhanced serine palmitoyltransferase expression in proliferating fibroblasts, transformed cell lines, and human tumors
J. Histochem. Cytochem.
51
715-726
2003
Homo sapiens
Hanada, K.; Nishijima, M.
Purification of mammalian serine palmitoyltransferase, a hetero-subunit enzyme for sphingolipid biosynthesis, by affinity-peptide chromatography
Methods Mol. Biol.
228
163-174
2003
Cricetulus griseus
Dobrzyn, A.; Dobrzyn, P.; Lee, S.; Miyazaki, M.; Cohen, P.; Asilmaz, E.; Hardie, D.G.; Friedman, J.M.; Ntambi, J.M.
Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
Am. J. Physiol.
288
E599-E607
2005
Mus musculus
Hornemann, T.; Wei, Y.; von Eckardstein, A.
Is the mammalian serine-palmitoyltransferase a high molecular weight complex?
Biochem. J.
405
157-164
2007
Homo sapiens
Glaros, E.N.; Kim, W.S.; Wu, B.J.; Suarna, C.; Quinn, C.M.; Rye, K.A.; Stocker, R.; Jessup, W.; Garner, B.
Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration
Biochem. Pharmacol.
73
1340-1346
2007
Mus musculus
McCampbell, A.; Truong, D.; Broom, D.C.; Allchorne, A.; Gable, K.; Cutler, R.G.; Mattson, M.P.; Woolf, C.J.; Frosch, M.P.; Harmon, J.M.; Dunn, T.M.; Brown, R.H.
Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy
Hum. Mol. Genet.
14
3507-3521
2005
Cricetulus griseus, Homo sapiens
Hornemann, T.; Richard, S.; Ruetti, M.F.; Wei, Y.; von Eckardstein, A.
Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase
J. Biol. Chem.
281
37275-37281
2006
Homo sapiens
Han, G.; Gable, K.; Yan, L.; Allen, M.J.; Wilson, W.H.; Moitra, P.; Harmon, J.M.; Dunn, T.M.
Expression of a novel marine viral single-chain serine palmitoyltransferase and construction of yeast and mammalian single-chain chimera
J. Biol. Chem.
281
39935-39942
2006
Coccolithovirus
He, X.; Guan, X.L.; Ong, W.Y.; Farooqui, A.A.; Wenk, M.R.
Expression, activity, and role of serine palmitoyltransferase in the rat hippocampus after kainate injury
J. Neurosci. Res.
85
423-432
2007
Rattus norvegicus
Chen, M.; Han, G.; Dietrich, C.R.; Dunn, T.M.; Cahoon, E.B.
The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase
Plant Cell
18
3576-3593
2006
Arabidopsis thaliana (Q9LSZ9), Arabidopsis thaliana
Baranowski, M.; Blachnio, A.; Zabielski, P.; Gorski, J.
Pioglitazone induces de novo ceramide synthesis in the rat heart
Prostaglandins Other Lipid Mediat.
83
99-111
2007
Rattus norvegicus
Ikushiro, H.; Islam, M.M.; Tojo, H.; Hayashi, H.
Molecular characterization of membrane-associated soluble serine palmitoyltransferases from Sphingobacterium multivorum and Bdellovibrio stolpii
J. Bacteriol.
189
5749-5761
2007
Bacteriovorax stolpii (A7BFV8), Bacteriovorax stolpii, Sphingobacterium multivorum (A7BFV6), Sphingobacterium multivorum, Sphingobacterium spiritivorum (A7BFV7), Sphingobacterium spiritivorum
Ikushiro, H.; Fujii, S.; Shiraiwa, Y.; Hayashi, H.
Acceleration of the substrate Calpha deprotonation by an analogue of the second substrate palmitoyl-CoA in Serine Palmitoyltransferase
J. Biol. Chem.
283
7542-7553
2008
Sphingomonas paucimobilis (Q93UV0)
Hong, K.K.; Cho, H.R.; Ju, W.C.; Cho, Y.; Kim, N.I.
A study on altered expression of serine palmitoyltransferase and ceramidase in psoriatic skin lesion
J. Korean Med. Sci.
22
862-867
2007
Homo sapiens
Yard, B.A.; Carter, L.G.; Johnson, K.A.; Overton, I.M.; Dorward, M.; Liu, H.; McMahon, S.A.; Oke, M.; Puech, D.; Barton, G.J.; Naismith, J.H.; Campopiano, D.J.
The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis
J. Mol. Biol.
370
870-886
2007
Sphingomonas paucimobilis
Park, T.S.; Rosebury, W.; Kindt, E.K.; Kowala, M.C.; Panek, R.L.
Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice
Pharmacol. Res.
58
45-51
2008
Mus musculus
Teng, C.; Dong, H.; Shi, L.; Deng, Y.; Mu, J.; Zhang, J.; Yang, X.; Zuo, J.
Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in Arabidopsis
Plant Physiol.
146
1322-1332
2008
Arabidopsis thaliana
Watson, M.L.; Coghlan, M.; Hundal, H.S.
Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells
Biochem. J.
417
791-801
2009
Rattus norvegicus
Granado, M.H.; Gangoiti, P.; Ouro, A.; Arana, L.; Gomez-Munoz, A.
Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages
Biochim. Biophys. Acta
1791
263-272
2009
Rattus norvegicus
Wei, J.; Yerokun, T.; Leipelt, M.; Haynes, C.A.; Radhakrishna, H.; Momin, A.; Kelly, S.; Park, H.; Wang, E.; Carton, J.M.; Uhlinger, D.J.; Merrill, A.H.
Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology
Biochim. Biophys. Acta
1791
746-756
2009
Homo sapiens (O15269)
Thuong, P.T.; Kang, K.W.; Kim, J.K.; Seo, D.B.; Lee, S.J.; Kim, S.H.; Oh, W.K.
Lithospermic acid derivatives from Lithospermum erythrorhizon increased expression of serine palmitoyltransferase in human HaCaT cells
Bioorg. Med. Chem. Lett.
19
1815-1817
2009
Homo sapiens
Ikushiro, H.; Islam, M.M.; Okamoto, A.; Hoseki, J.; Murakawa, T.; Fujii, S.; Miyahara, I.; Hayashi, H.
Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum
J. Biochem.
146
549-562
2009
Sphingobacterium multivorum (A7BFV6), Sphingobacterium multivorum, Sphingobacterium multivorum GTC97 (A7BFV6), Sphingobacterium multivorum GTC97
Shiraiwa, Y.; Ikushiro, H.; Hayashi, H.
Multifunctional role of His159in the catalytic reaction of serine palmitoyltransferase
J. Biol. Chem.
284
15487-15495
2009
Sphingomonas paucimobilis
Raman, M.C.; Johnson, K.A.; Yard, B.A.; Lowther, J.; Carter, L.G.; Naismith, J.H.; Campopiano, D.J.
The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics
J. Biol. Chem.
284
17328-17339
2009
Homo sapiens, Sphingomonas paucimobilis (Q93UV0), Sphingomonas paucimobilis, Sphingomonas paucimobilis EY2395 (Q93UV0)
Hornemann, T.; Penno, A.; Ruetti, M.F.; Ernst, D.; Kivrak-Pfiffner, F.; Rohrer, L.; von Eckardstein, A.
The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases
J. Biol. Chem.
284
26322-26330
2009
Homo sapiens
Ruetti, M.F.; Richard, S.; Penno, A.; von Eckardstein, A.; Hornemann, T.
An improved method to determine serine palmitoyltransferase activity
J. Lipid Res.
50
1237-1244
2009
Homo sapiens
Momin, A.A.; Park, H.; Allegood, J.C.; Leipelt, M.; Kelly, S.L.; Merrill, A.H.; Hanada, K.
Characterization of mutant serine palmitoyltransferase 1 in LY-B cells
Lipids
44
725-732
2009
Cricetulus griseus
Takahashi, Y.; Berberich, T.; Kanzaki, H.; Matsumura, H.; Saitoh, H.; Kusano, T.; Terauchi, R.
Serine palmitoyltransferase, the first step enzyme in sphingolipid biosynthesis, is involved in nonhost resistance
Mol. Plant Microbe Interact.
22
31-38
2009
Nicotiana benthamiana (B3Y000), Nicotiana benthamiana (B3Y9H2), Nicotiana benthamiana
Gan, Y.; Zhang, L.; Zhang, Z.; Dong, S.; Li, J.; Wang, Y.; Zheng, X.
The LCB2 subunit of the sphingolip biosynthesis enzyme serine palmitoyltransferase can function as an attenuator of the hypersensitive response and Bax-induced cell death
New Phytol.
181
127-146
2009
Brassica rapa subsp. oleifera (B5LED9), Arabidopsis thaliana (Q94IB8), Arabidopsis thaliana (Q9LSZ9)
Han, G.; Gupta, S.D.; Gable, K.; Niranjanakumari, S.; Moitra, P.; Eichler, F.; Brown, R.H.; Harmon, J.M.; Dunn, T.M.
Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities
Proc. Natl. Acad. Sci. USA
106
8186-8191
2009
Homo sapiens
Rotthier, A.; Auer-Grumbach, M.; Janssens, K.; Baets, J.; Penno, A.; Almeida-Souza, L.; Van Hoof, K.; Jacobs, A.; De Vriendt, E.; Schlotter-Weigel, B.; Loescher, W.; Vondracek, P.; Seeman, P.; De Jonghe, P.; Van Dijck, P.; Jordanova, A.; Hornemann, T.; Timmerman, V.
Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I
Am. J. Hum. Genet.
87
513-522
2010
Homo sapiens (O15270 and Q9NUV7), Homo sapiens
Altura, B.M.; Shah, N.C.; Li, Z.; Jiang, X.C.; Perez-Albela, J.L.; Altura, B.T.
Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c
Am. J. Physiol. Heart Circ. Physiol.
299
H932-H938
2010
Rattus norvegicus
Raman, M.C.; Johnson, K.A.; Clarke, D.J.; Naismith, J.H.; Campopiano, D.J.
The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein
Biopolymers
93
811-822
2010
Rhizorhabdus wittichii
Lowther, J.; Charmier, G.; Raman, M.C.; Ikushiro, H.; Hayashi, H.; Campopiano, D.J.
Role of a conserved arginine residue during catalysis in serine palmitoyltransferase
FEBS Lett.
585
1729-1734
2011
Rhizorhabdus wittichii
Rotthier, A.; Penno, A.; Rautenstrauss, B.; Auer-Grumbach, M.; Stettner, G.M.; Asselbergh, B.; Van Hoof, K.; Sticht, H.; Levy, N.; Timmerman, V.; Hornemann, T.; Janssens, K.
Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I
Hum. Mutat.
32
E2211-E2225
2011
Homo sapiens (O15269), Homo sapiens
Gable, K.; Gupta, S.D.; Han, G.; Niranjanakumari, S.; Harmon, J.M.; Dunn, T.M.
A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity
J. Biol. Chem.
285
22846-22852
2010
Homo sapiens
Lowther, J.; Yard, B.A.; Johnson, K.A.; Carter, L.G.; Bhat, V.T.; Raman, M.C.; Clarke, D.J.; Ramakers, B.; McMahon, S.A.; Naismith, J.H.; Campopiano, D.J.
Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation
Mol. Biosyst.
6
1682-1693
2010
Sphingomonas paucimobilis (Q93UV0), Sphingomonas paucimobilis
Beattie, A.E.; Gupta, S.D.; Frankova, L.; Kazlauskaite, A.; Harmon, J.M.; Dunn, T.M.; Campopiano, D.J.
The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations
BioMed Res. Int.
2013
194371
2013
Homo sapiens (O15269 and O15270), Homo sapiens, Sphingomonas paucimobilis (Q93UV0), Sphingomonas paucimobilis
Beattie, A.E.; Clarke, D.J.; Wadsworth, J.M.; Lowther, J.; Sin, H.L.; Campopiano, D.J.
Reconstitution of the pyridoxal 5-phosphate (PLP) dependent enzyme serine palmitoyltransferase (SPT) with pyridoxal reveals a crucial role for the phosphate during catalysis
Chem. Commun. (Camb. )
49
7058-7060
2013
Sphingomonas paucimobilis (Q93UV0)
Hirata, Y.; Yamamori, N.; Kono, N.; Lee, H.C.; Inoue, T.; Arai, H.
Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein
Genes Cells
18
397-409
2013
Homo sapiens (Q969W0)
Bode, H.; Bourquin, F.; Suriyanarayanan, S.; Wei, Y.; Alecu, I.; Othman, A.; Von Eckardstein, A.; Hornemann, T.
HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship
Hum. Mol. Genet.
25
853-865
2016
Homo sapiens (O15269 and O15270), Homo sapiens
Wadsworth, J.M.; Clarke, D.J.; McMahon, S.A.; Lowther, J.P.; Beattie, A.E.; Langridge-Smith, P.R.; Broughton, H.B.; Dunn, T.M.; Naismith, J.H.; Campopiano, D.J.
The chemical basis of serine palmitoyltransferase inhibition by myriocin
J. Am. Chem. Soc.
135
14276-14285
2013
Sphingomonas paucimobilis (Q93UV0)
Harmon, J.M.; Bacikova, D.; Gable, K.; Gupta, S.D.; Han, G.; Sengupta, N.; Somashekarappa, N.; Dunn, T.M.
Topological and functional characterization of the ssSPTs, small activating subunits of serine palmitoyltransferase
J. Biol. Chem.
288
10144-10153
2013
Homo sapiens
Taouji, S.; Higa, A.; Delom, F.; Palcy, S.; Mahon, F.X.; Pasquet, J.M.; Bosse, R.; Segui, B.; Chevet, E.
Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival
J. Biol. Chem.
288
17190-17201
2013
Canis lupus familiaris (E2RKV3), Canis lupus familiaris, Homo sapiens (O15269), Homo sapiens
Chakraborty, M.; Lou, C.; Huan, C.; Kuo, M.S.; Park, T.S.; Cao, G.; Jiang, X.C.
Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis
J. Clin. Invest.
123
1784-1797
2013
Mus musculus (P97363), Mus musculus
Liu, L.; Martin, R.; Chan, C.
Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases
Neurobiol. Aging
34
540-550
2013
Rattus norvegicus, Rattus norvegicus Sprague Dawley
Ernst, D.; Murphy, S.M.; Sathiyanadan, K.; Wei, Y.; Othman, A.; Laura, M.; Liu, Y.T.; Penno, A.; Blake, J.; Donaghy, M.; Houlden, H.; Reilly, M.M.; Hornemann, T.
Novel HSAN1 mutation in serine palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificity
Neuromolecular Med.
17
47-57
2015
Homo sapiens (O15270), Homo sapiens
Kimberlin, A.N.; Majumder, S.; Han, G.; Chen, M.; Cahoon, R.E.; Stone, J.M.; Dunn, T.M.; Cahoon, E.B.
Arabidopsis 56-amino acid serine palmitoyltransferase-interacting proteins stimulate sphingolipid synthesis, are essential, and affect mycotoxin sensitivity
Plant Cell
25
4627-4639
2013
Arabidopsis thaliana
Miklosz, A.; Lukaszuk, B.; Baranowski, M.; Gorski, J.; Chabowski, A.
Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes
PLoS ONE
8
e85547
2013
Rattus norvegicus
Adachi, R.; Asano, Y.; Ogawa, K.; Oonishi, M.; Tanaka, Y.; Kawamoto, T.
Pharmacological characterization of synthetic serine palmitoyltransferase inhibitors by biochemical and cellular analyses
Biochem. Biophys. Res. Commun.
497
1171-1176
2018
Homo sapiens (O15269 AND O15270 AND Q9NUV7), Homo sapiens
Han, G.; Gupta, S.D.; Gable, K.; Bacikova, D.; Sengupta, N.; Somashekarappa, N.; Proia, R.L.; Harmon, J.M.; Dunn, T.M.
The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization
Biochim. Biophys. Acta
1864
245-259
2019
Saccharomyces cerevisiae
Choe, H.; Cha, M.; Stewart, J.
Semi-rational approach to expand the acyl-CoA chain length tolerance of Sphingomonas paucimobilis serine palmitoyltransferase
Enzyme Microb. Technol.
137
109515
2020
Sphingomonas paucimobilis (Q93UV0), Sphingomonas paucimobilis
Harrison, P.J.; Gable, K.; Somashekarappa, N.; Kelly, V.; Clarke, D.J.; Naismith, J.H.; Dunn, T.M.; Campopiano, D.J.
Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase
J. Lipid Res.
60
953-962
2019
Homo sapiens (O15269 AND O15270 AND Q969W0), Homo sapiens, Sphingomonas paucimobilis
Davis, D.L.; Mahawar, U.; Pope, V.S.; Allegood, J.; Sato-Bigbee, C.; Wattenberg, B.W.
Dynamics of sphingolipids and the serine palmitoyltransferase complex in rat oligodendrocytes during myelination
J. Lipid Res.
61
505-522
2020
Rattus norvegicus (D4A2H2 AND Q3B7D2)
Li, J.; Yin, J.; Rong, C.; Li, K.E.; Wu, J.X.; Huang, L.Q.; Zeng, H.Y.; Sahu, S.K.; Yao, N.
Orosomucoid proteins interact with the small subunit of serine palmitoyltransferase and contribute to sphingolipid homeostasis and stress responses in Arabidopsis
Plant Cell
28
3038-3051
2016
Arabidopsis thaliana
Ziv, C.; Malitsky, S.; Othman, A.; Ben-Dor, S.; Wei, Y.; Zheng, S.; Aharoni, A.; Hornemann, T.; Vardi, A.
Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga
Proc. Natl. Acad. Sci. USA
113
E1907-E1916
2016
Emiliania huxleyi, Emiliania huxleyi virus sp., Emiliania huxleyi virus sp. 201, Emiliania huxleyi CCMP374
html completed
