2.3.1.47: 8-amino-7-oxononanoate synthase
This is an abbreviated version!
For detailed information about 8-amino-7-oxononanoate synthase, go to the full flat file.
Word Map on EC 2.3.1.47
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2.3.1.47
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biotin
-
pimeloyl-coa
-
dethiobiotin
-
plp-dependent
-
aldimine
-
sphaericus
-
tympanometric
-
pyridoxal-5'-phosphate-dependent
-
alpha-oxoamine
-
2-amino-3-ketobutyrate
-
agriculture
-
medicine
-
drug development
- 2.3.1.47
- biotin
- pimeloyl-coa
- dethiobiotin
-
plp-dependent
-
aldimine
- sphaericus
-
tympanometric
-
pyridoxal-5'-phosphate-dependent
-
alpha-oxoamine
-
2-amino-3-ketobutyrate
- agriculture
- medicine
- drug development
Reaction
Synonyms
7,8-diaminopelargonic acid aminotransferase, 7-KAP synthetase, 7-keto-8-aminopelargonate synthase, 7-keto-8-aminopelargonate synthetase, 7-keto-8-aminopelargonic acid synthase, 7-keto-8-aminopelargonic acid synthetase, 7-keto-8-aminopelargonic synthetase, 7-oxo-8-aminononanoate synthase, 8-amino-7-oxononanoate synthase, 8-amino-7-oxopelargonate synthase, AON synthase, AONS, AOP synthase, AtbioF, BioF, bioF protein, DAPA AT, KAPA synthase, KAPA synthetase, KAPAS, More, SxtA, synthase, 7-oxo-8-aminononanoate, synthetase, 7-keto-8-aminopelargonate
ECTree
2.3.1.47 8-amino-7-oxononanoate synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.47 - 8-amino-7-oxononanoate synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine
(7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid)
pimeloyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
-
-
?
pimeloyl-[acyl-carrier protein] + L-alanine
8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
additional information
?
-
the enzyme catalyzes the first committed enzyme of the biotin synthesis pathway
-
-
?
(S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine
(7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid)
-
37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, varying S-adenosyl-L-methionine, 9 microM (S)-8-amino-7-oxononanoic acid, varying inhibitor concentration
-
-
?
(S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine
(7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid)
-
37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, varying S-adenosyl-L-methionine, 9 microM (S)-8-amino-7-oxononanoic acid, varying inhibitor concentration
-
-
?
(S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine
(7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid)
-
37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, 1 mM S-adenosyl-L-methionine, 2 microM (S)-8-amino-7-oxononanoic acid
-
-
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
Erwinia aroidea
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
Erwinia aroidea
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
-
-
-
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
the enzyme catalyzes the first committed step in the four step pathway, the decarboxylative condensation of L-alanine and pimeloyl-CoA to give (7S)-8-amino-7-oxononanoate
-
-
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
second step in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
second step in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
ir
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
first committed step in the biotin biosynthesis pathway
-
-
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
Sporobolomyces coprophilus
-
i.e. pimeloyl-CoA
i.e. 7-oxo-8-amino-pelargonic acid
?
6-carboxyhexanoyl-CoA + L-alanine
8-amino-7-oxononanoate + CoA + CO2
Sporobolomyces coprophilus
-
reaction in biotin biosynthesis
i.e. 7-oxo-8-amino-pelargonic acid
?
pimeloyl-[acyl-carrier protein] + L-alanine
8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
-
-
-
?
pimeloyl-[acyl-carrier protein] + L-alanine
8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
-
-
-
?
pimeloyl-[acyl-carrier protein] + L-alanine
8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
-
-
-
-
?
pimeloyl-[acyl-carrier protein] + L-alanine
8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
-
-
-
?
