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2.3.1.45: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase

This is an abbreviated version!
For detailed information about N-acetylneuraminate 7-O(or 9-O)-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.45

Reaction

acetyl-CoA
+
N-acetylneuraminate
=
CoA
+
N-acetyl-7-O(or 9-O)-acetylneuraminate

Synonyms

7(9)-OAT, acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(or7)-O-acetyltransferase, acetyltransferase, N-acetylneuraminate 9(7)-O-, CAS1 domain-containing protein 1, CASD1, glycoprotein 7(9)-O-acetyltransferase, group B streptococcal sialic acid O-acetyltransferase, More, N-acetylneuraminate 7(8)-O-acetyltransferase, N-acetylneuraminate 7,8-O-acetyltransferase, N-acetylneuraminate 9(7)-O-acetyltransferase, N-acetylneuraminate O7-(or O9-)acetyltransferase, NeuD, NeuD O-acetyltransferase, OAT, Sia O-acetyltransferase, sialate O-acetyltransferase, sialate-7(9)-O-acetyltransferase, sialate-O-acetyl transferase, sialate-O-acetyltransferase, sialyl-O-acetyltransferase, SOAT

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.45 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase

General Stability

General Stability on EC 2.3.1.45 - N-acetylneuraminate 7-O(or 9-O)-acetyltransferase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
activity is stable to the first cycle of freezing, cannot be refrozen after thawing
-
enzyme is labile and difficult to solubilize
-
lyophilisation causes loss of 20-30% activity, storage in lyophilized stage leads to additional loss of 60% activity
-
Neu5Ac or CMP-Neu5Ac are strongly required for stabilization of the solubilized enzyme during purification
-