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2.3.1.45: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase

This is an abbreviated version!
For detailed information about N-acetylneuraminate 7-O(or 9-O)-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.45

Reaction

acetyl-CoA
+
N-acetylneuraminate
=
CoA
 +
N-acetyl-7-O(or 9-O)-acetylneuraminate

Synonyms

7(9)-OAT, acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(or7)-O-acetyltransferase, acetyltransferase, N-acetylneuraminate 9(7)-O-, CAS1 domain-containing protein 1, CASD1, glycoprotein 7(9)-O-acetyltransferase, group B streptococcal sialic acid O-acetyltransferase, More, N-acetylneuraminate 7(8)-O-acetyltransferase, N-acetylneuraminate 7,8-O-acetyltransferase, N-acetylneuraminate 9(7)-O-acetyltransferase, N-acetylneuraminate O7-(or O9-)acetyltransferase, NeuD, NeuD O-acetyltransferase, OAT, Sia O-acetyltransferase, sialate O-acetyltransferase, sialate-7(9)-O-acetyltransferase, sialate-O-acetyl transferase, sialate-O-acetyltransferase, sialyl-O-acetyltransferase, SOAT

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.45 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase

Cloned

Cloned on EC 2.3.1.45 - N-acetylneuraminate 7-O(or 9-O)-acetyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of cDNAs from melanoma genetic library that induce 9-O-acetylation of sialic acids, expression in COS cells
-
expressed in A-549, HEK-293, MDCK-NBL2, MDCK type I, and MDCK type II cells
expressed in COS-7 cells, GFP-fusion protein expressed in Sf9 cells
expressed in Escherichia coli AD202 cells
-
gene neuD, DNA and amino acid sequence determination and analysis, phylogenetic analysis, homology modeling of NeuD
-
gene neuD, DNA and amino acid sequence determination and analysis, phylogenetic analysis, homology modeling of NeuD, functional complementation of an enzyme-deficient neuD-mutant Streptococcus sp. strain
orf11 gene, DNA and amino acid sequence determination and analysis, expression as soluble enzyme in Escherichia coli strain AD202
recombinant expression of N-terminally V5-tagged and C-terminally Myc-tagged enzyme in the murine fibroblast cell line LM-TK-, the enzyme co-localizes with the Golgi marker alpha-mannosidase II, and cytosolic and luminal orientation of N- and C-terminus, respectively, recombinant expression of a soluble secreted form of CASD1, which encompasses the SGNH-like luminal domain and a C-terminal Myc-His6-tag, in Spodoptera frugiperda SF9 cells via baculovirus transfection