2.3.1.41: beta-ketoacyl-[acyl-carrier-protein] synthase I
This is an abbreviated version!
For detailed information about beta-ketoacyl-[acyl-carrier-protein] synthase I, go to the full flat file.
Word Map on EC 2.3.1.41
-
2.3.1.41
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polyketide
-
cerulenin
-
malonyl-coa
-
thioesterase
-
elongase
-
enoyl
-
thiolactomycin
-
transacylase
-
mycolic
-
malonyl-acp
-
acyl-acps
-
very-long-chain
-
dehydrase
-
4'-phosphopantetheine
-
cuphea
-
vlcfas
-
cis-vaccenic
-
malonyl-coa:acp
-
actinorhodin
-
platensimycin
-
acetyl-acp
-
drug development
-
6-methylsalicylic
-
3-oxoacyl-acps
-
claisen
-
pharmacology
-
nutrition
-
medicine
- 2.3.1.41
- polyketide
- cerulenin
- malonyl-coa
-
thioesterase
- elongase
-
enoyl
- thiolactomycin
-
transacylase
-
mycolic
- malonyl-acp
- acyl-acps
-
very-long-chain
-
dehydrase
- 4'-phosphopantetheine
- cuphea
-
vlcfas
-
cis-vaccenic
-
malonyl-coa:acp
-
actinorhodin
- platensimycin
- acetyl-acp
- drug development
-
6-methylsalicylic
- 3-oxoacyl-acps
-
claisen
- pharmacology
- nutrition
- medicine
Reaction
Synonyms
3-ketoacyl-ACP synthase, 3-ketoacyl-acyl carrier protein synthase, 3-ketoacyl-acyl-carrier protein synthase I, 3-oxoacyl synthase, 3-oxoacyl-[acyl-carrier-protein] synthase, acyl-malonyl(acyl-carrier-protein)-condensing enzyme, B-ketoacyl-ACP synthase I, beta-ketoacyl ACP synthase I, beta-ketoacyl acyl carrier protein synthase, beta-ketoacyl acyl carrier protein synthase I, beta-ketoacyl synthase, beta-ketoacyl synthetase, beta-ketoacyl [ACP] synthase, beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP synthase I, beta-ketoacyl-ACP synthetase, beta-ketoacyl-ACP-synthase, beta-ketoacyl-ACP-synthase I, beta-ketoacyl-acyl carrier protein synthase I, beta-ketoacyl-acyl carrier protein synthetase, beta-ketoacyl-acyl-ACP synthase I, beta-ketoacyl-CoA synthase-I, beta-ketoacyl-[acyl carrier protein (ACP)] synthase III, beta-ketoacyl-[acyl carrier protein] synthase, beta-ketoacyl-[acyl carrier protein] synthase I, beta-ketoacyl-[acyl-carrier-protein] synthase I, beta-ketoacylsynthase, condensing enzyme, Cys-His-His-type beta-ketoacyl-acyl carrier protein synthase, DpsC, elongase, elongating beta-ketoacyl-acyl carrier protein synthase, FabB, FabBF, FabH, fatty acid condensing enzyme, KAS, Kas A, KAS I, KasA, KasI, KASI-1, KASI-2, KCSI, More, OsKASI, synthase, 3-oxoacyl-[acyl-carrier-protein]
ECTree
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Reference on EC 2.3.1.41 - beta-ketoacyl-[acyl-carrier-protein] synthase I
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shimakata, T.; Stumpf, P.K.
The procaryotic nature of the fatty acid synthetase of developing Carthamus tinctorius L. (Safflower) seeds
Arch. Biochem. Biophys.
217
144-154
1982
Carthamus tinctorius
Shimakata, T.; Stumpf, P.K.
The purification and function of acetyl coenzyme A:acyl carrier protein transacylase
J. Biol. Chem.
258
3592-3598
1983
Brassica juncea, Carthamus tinctorius, Cuphea lutea, Pisum sativum, Spinacia oleracea
Hendren, R.W.; Bloch, K.
Fatty acid synthetases from Euglena gracilis. Separation of component activities of the ACP-dependent fatty acid synthetase and partial purification of the beta-ketoacyl-ACP synthetase
J. Biol. Chem.
255
1504-1508
1980
Euglena gracilis, Euglena gracilis Z
Vagelos, R.P.
Acyl group transfer (acyl carrier protein)
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
8
155-199
1973
Clostridium kluyveri, Escherichia coli
-
Prescott, D.J.; Vagelos, P.R.
Acyl carrier protein
Adv. Enzymol. Relat. Areas Mol. Biol.
36
269-311
1972
Escherichia coli
Toomey, R.E.; Wakil, S.J.
Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli
J. Biol. Chem.
241
1159-1165
1966
Escherichia coli
Alberts, A.W.; Majerus, P.W.; Vagelos, P.R.
beta-Ketoacyl acyl carrier protein synthase
Methods Enzymol.
14
57-60
1969
Escherichia coli
-
Garwin, J.L.; Klages, A.L.; Cronan, J.E.
Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli
J. Biol. Chem.
255
11949-11956
1980
Escherichia coli
Alberts, A.W.; Bell, R.M.; Vagelos, P.R.
Acyl carrier protein. XV. Studies of beta-ketoacyl-acyl carrier protein synthetase
J. Biol. Chem.
247
3190-3198
1972
Escherichia coli
D'Agnolo, G.; Rosenfeld, I.S.; Vagelos, P.R.
beta-Ketoacyl-acyl carrier protein synthetase. Characterization of the acyl-enzyme intermediate
J. Biol. Chem.
250
5283-5288
1975
Escherichia coli
D'Agnolo, G.; Rosenfeld, I.S.; Vagelos, P.R.
Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli
J. Biol. Chem.
250
5289-5294
1975
Escherichia coli, Escherichia coli B / ATCC 11303
Shimakata, T.; Stumpf, P.L.
Purification and characterization of beta-ketoacyl-[acyl-carrier-protein] synthetase I from Spinacia oleracea leaves
Arch. Biochem. Biophys.
220
39-45
1983
Spinacia oleracea
Schuz, R.; Ebel, J.; Hahlbrock, K.
Partial purification of beta-ketoacyl-acyl acrrier protein synthase from a higher plant
FEBS Lett.
140
207-209
1982
Petroselinum crispum
-
MacKintosh, R.W.; Hardie, D.G.; Slabas, A.R.
beta-Ketoacyl-acyl-carrier protein synthase from developing seeds of oilseed rape (Brassica napus)
Biochem. Soc. Trans.
17
686-687
1989
Brassica napus
-
MacKintosh, R.W.; Hardie, D.G.; Slabas, A.R.
A new assay procedure to study the induction of beta-ketoacyl-ACP synthase I and II, and the complete purification of beta-ketoacyl-ACP synthase I from developing seeds of oilseed rape (Brassica napus)
Biochim. Biophys. Acta
1002
114-124
1989
Brassica napus
-
Shimakata, T.; Stumpf, P.L.
Isolation and function of spinach leaf beta-ketoacyl-[acyl-carrier-protein] synthases
Proc. Natl. Acad. Sci. USA
79
5808-5812
1982
Spinacia oleracea
Siggaard-Andersen, M.; Kauppinen, S.; von Wettstein-Knowles, P.
Primary structure of a cerulenin-binding beta-ketoacyl-[acyl carrier protein] synthase from barley chloroplasts
Proc. Natl. Acad. Sci. USA
88
4114-4118
1991
Hordeum vulgare, Spinacia oleracea
Clough, R.; Matthis, A.L.; Barnum, S.R.; Jaworski, J.G.
Purification and characterization of 3-ketoacyl-acyl carrier protein synthase III from spinach. A condensing enzyme utilizing acetyl-coenzyme A to initiate fatty acid synthesis
J. Biol. Chem.
267
20992-20998
1992
Spinacia oleracea
Verwoert, I.I.G.S.; van der Linden, K.H.; Walsh, M.C.; Nijkamp, H.J.J.; Stuitje, A.R.
Modification of Brassica napus seed oil by expression of the Escherichia coli fabH gene, encoding 3-ketoacyl-acyl carrier protein synthase III
Plant Mol. Biol.
27
875-886
1995
Brassica napus, Escherichia coli
Han, L.; Lobo, S.; Reynolds, K.A.
Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis
J. Bacteriol.
180
4481-4486
1998
Streptomyces glaucescens
Bao, W.; Sheldon, P.J.; Hutchinson, C.R.
Purification and properties of the Streptomyces peucetius DpsC beta-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis
Biochemistry
38
9752-9757
1999
Streptomyces peucetius
Domergue, F.; Post-Beittenmiller, D.
Biochemical characterization of 3-ketoacyl-acyl carrier protein synthase II from leek epidermis
Biochem. Soc. Trans.
28
610-613
2000
Allium ampeloprasum
Val, D.; Banu, G.; Seshadri, K.; Lindqvist, Y.; Dehesh, K.
Re-engineering ketoacyl synthase specificity
Structure
8
565-566
2000
Synechocystis sp.
Choi, K.H.; Heath, R.J.; Rock, C.O.
beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis
J. Bacteriol.
182
365-370
2000
Bacillus subtilis, Escherichia coli
Smirnova, N.; Reynolds, K.A.
Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III
J. Bacteriol.
183
2335-2342
2001
Streptomyces glaucescens
Khandekar, S.S.; Gentry, D.R.; Van Aller, G.S.; Warren, P.; Xiang, H.; Silverman, C.; Doyle, M.L.; Chambers, P.A.; Konstantinidis, A.K.; Brandt, M.; Daines, R.A.; Lonsdale, J.T.
Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)
J. Biol. Chem.
276
30024-30030
2001
Escherichia coli, Haemophilus influenzae, Streptococcus pneumoniae (P0A3C5)
Moche, M.; Dehesh, K.; Edwards, P.; Lindqvist, Y.
The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54.ANG. resolution and its relationship to other condensing enzymes
J. Mol. Biol.
305
491-503
2001
Synechocystis sp.
Price, A.C.; Choi, K.H.; Heath, R.J.; Li, Z.; White, S.W.; Rock, C.O.
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism
J. Biol. Chem.
276
6551-6559
2001
Escherichia coli
McGuire, K.A.; Siggaard-Andersen, M.; Bangera, M.G.; Olsen, J.G.; von Wettstein-Knowles, P.
beta-Ketoacyl-[acyl carrier protein] synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analyses of mutations in the active site pocket
Biochemistry
40
9836-9845
2001
Escherichia coli
Witkowski, A.; Joshi, A.K.; Smith, S.
Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase
Biochemistry
41
10877-10887
2002
Rattus norvegicus
He, X.; Reynolds, K.A.
Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
Antimicrob. Agents Chemother.
46
1310-1318
2002
Staphylococcus aureus (P99159)
Schutt, B.S.; Abbadi, A.; Loddenkotter, B.; Brummel, M.; Spener, F.
beta-Ketoacyl-acyl carrier protein synthase IV: a key enzyme for regulation of medium-chain fatty acid synthesis in Cuphea lanceolata seeds
Planta
215
847-854
2002
Cuphea lanceolata
Mekhedov, S.; Cahoon, E.B.; Ohlrogge, J.
An unusual seed-specific 3-ketoacyl-ACP synthase associated with the biosynthesis of petroselinic acid in coriander
Plant Mol. Biol.
47
507-518
2001
Coriandrum sativum
Olsen, J.G.; Rasmussen, A.V.; von Wettstein-Knowles, P.; Henriksen, A.
Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis
FEBS Lett.
577
170-174
2004
Arabidopsis thaliana (Q8L3X9), Arabidopsis thaliana
Price, A.C.; Rock, C.O.; White, S.W.
The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae
J. Bacteriol.
185
4136-4143
2003
Streptococcus pneumoniae
Lai, C.Y.; Cronan, J.E.
beta-Ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis
J. Biol. Chem.
278
51494-51503
2003
Lactococcus lactis
Yasuno, R.; von Wettstein-Knowles, P.; Wada, H.
Identification and molecular characterization of the beta-ketoacyl-[acyl carrier protein] synthase component of the Arabidopsis mitochondrial fatty acid synthase
J. Biol. Chem.
279
8242-8251
2004
Arabidopsis thaliana (Q8L3X9), Arabidopsis thaliana
Zhang, L.; Joshi, A.K.; Hofmann, J.; Schweizer, E.; Smith, S.
Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain
J. Biol. Chem.
280
12422-12429
2005
Homo sapiens
Brown, A.K.; Sridharan, S.; Kremer, L.; Lindenberg, S.; Dover, L.G.; Sacchettini, J.C.; Besra, G.S.
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III mtFabH: Factors influencing catalysis and substrate specificity
J. Biol. Chem.
280
32539-32547
2005
Mycobacterium tuberculosis
Musayev, F.; Sachdeva, S.; Scarsdale, J.N.; Reynolds, K.A.; Wright, H.T.
Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A
J. Mol. Biol.
346
1313-1321
2005
Mycobacterium tuberculosis
Kursula, P.; Sikkilae, H.; Fukao, T.; Kondo, N.; Wierenga, R.K.
High resolution crystal structures of human cytosolic thiolase (CT): A comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I
J. Mol. Biol.
347
189-201
2005
Escherichia coli (P0A953), Escherichia coli
Qiu, X.; Choudhry, A.E.; Janson, C.A.; Grooms, M.; Daines, R.A.; Lonsdale, J.T.; Khandekar, S.S.
Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
Protein Sci.
14
2087-2094
2005
Staphylococcus aureus
Dawe, J.H.; Porter, C.T.; Thornton, J.M.; Tabor, A.B.
A template search reveals mechanistic similarities and differences in beta-ketoacyl synthases (KAS) and related enzymes
Proteins
52
427-435
2003
Escherichia coli
Rendina, A.R.; Cheng, D.
Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates
Biochem. J.
388
895-903
2005
Rattus norvegicus
von Wettstein-Knowles, P.; Olsen, J.G.; McGuire, K.A.; Henriksen, A.
Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases
FEBS J.
273
695-710
2006
Escherichia coli
Salas, J.J.; Martinez-Force, E.; Garces, R.
Very long chain fatty acid synthesis in sunflower kernels
J. Agric. Food Chem.
53
2710-2716
2005
Helianthus annuus
Lack, G.; Homberger-Zizzari, E.; Folkers, G.; Scapozza, L.; Perozzo, R.
Recombinant expression and biochemical characterization of the unique elongating beta-ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of Plasmodium falciparum using natural and artificial substrates
J. Biol. Chem.
281
9538-9546
2006
Plasmodium falciparum
Stephens, J.L.; Lee, S.H.; Paul, K.S.; Englund, P.T.
Mitochondrial fatty acid synthesis in Trypanosoma brucei
J. Biol. Chem.
282
4427-4436
2007
Trypanosoma brucei (Q586W9), Trypanosoma brucei
Wang, J.; Kodali, S.; Lee, S.H.; Galgoci, A.; Painter, R.; Dorso, K.; Racine, F.; Motyl, M.; Hernandez, L.; Tinney, E.; Colletti, S.L.; Herath, K.; Cummings, R.; Salazar, O.; Gonzalez, I.; Basilio, A.; Vicente, F.; Genilloud, O.; Pelaez, F.; Jayasuriya, H.; Young, K.; Cully, D.F.; Singh, S.B.
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
Proc. Natl. Acad. Sci. USA
104
7612-7616
2007
Staphylococcus aureus
Christensen, C.E.; Kragelund, B.B.; von Wettstein-Knowles, P.; Henriksen, A.
Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase
Protein Sci.
16
261-272
2007
Homo sapiens (Q9NWU1), Homo sapiens
Feng, Y.; Cronan, J.E.
Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB
J. Biol. Chem.
284
29526-29535
2009
Escherichia coli
Doan, T.; Kim, J.; Mac, Q.; Chung, C.; Sampath, N.; Kim, J.; Ahn, Y.; Kang, L.
Crystallization and preliminary X-ray crystallographic analysis of beta-ketoacyl-ACP synthase I (XoFabB) from Xanthomonas oryzae pv. oryzae
Acta Crystallogr. Sect. F
67
1548-1550
2011
Xanthomonas oryzae pv. oryzae
Borgaro, J.; Chang, A.; MacHutta, C.; Zhang, X.; Tonge, P.
Substrate recognition by beta-ketoacyl-ACP synthases
Biochemistry
50
10678-10686
2011
Escherichia coli, Mycobacterium tuberculosis
Lee, J.; Jeong, K.; Lee, J.; Kang, D.; Kim, Y.
In silico screening of a novel inhibitor of beta-ketoacyl acyl carrier protein synthase i
Bull. Korean Chem. Soc.
32
1645-1649
2011
Escherichia coli, Escherichia coli (E2QPI4)
-
Wu, G.; Xue, H.
Arabidopsis beta-ketoacyl-[acyl carrier protein] synthase I is crucial for fatty acid synthesis and plays a role in chloroplast division and embryo development
Plant Cell
22
3726-3744
2010
Arabidopsis thaliana (P52410)
Sabbagh, G.; Berakdar, N.
Docking studies of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli
J. Mol. Graph. Model.
61
214-223
2015
Escherichia coli (E2QPI4), Escherichia coli
Yuan, Y.; Liang, Y.; Li, B.; Zheng, Y.; Luo, X.; Dongdong, L.
Cloning and function characterization of a beta-ketoacyl-acyl-ACP synthase I from coconut (Cocos nucifera L.) endosperm
Plant Mol. Biol. Rep.
33
1131-1140
2015
Cocos nucifera (V9N3I8)
-
Ding, W.; Lin, L.; Zhang, B.; Xiang, X.; Wu, J.; Pan, Z.; Zhu, S.
OsKASI, a beta-ketoacyl-[acyl carrier protein] synthase I, is involved in root development in rice (Oryza sativa L.)
Planta
242
203-213
2015
Oryza sativa
Jayaraman, M.; Rajendra, S.; Ramadas, K.
Structural insight into conformational dynamics of non-active site mutations in KasA A Mycobacterium tuberculosis target protein
Gene
720
144082
2019
Mycobacterium tuberculosis (P9WQD9), Mycobacterium tuberculosis H37Rv (P9WQD9)
Morvan, C.; Halpern, D.; Kenanian, G.; Pathania, A.; Anba-Mondoloni, J.; Lamberet, G.; Gruss, A.; Gloux, K.
The Staphylococcus aureus FASII bypass escape route from FASII inhibitors
Biochimie
141
40-46
2017
Staphylococcus aureus
Yang, T.; Xu, R.; Chen, J.; Liu, A.
beta-Ketoacyl-acyl carrier protein synthase I (KASI) plays crucial roles in the plant growth and fatty acids synthesis in tobacco
Int. J. Mol. Sci.
17
1287
2016
Nicotiana tabacum (A0A3G1E3Q4), Nicotiana tabacum (A0A3G1E3S8), Nicotiana tabacum
Xiong, W.; Wei, Q.; Wu, P.; Zhang, S.; Li, J.; Chen, Y.; Li, M.; Jiang, H.; Wu, G.
Molecular cloning and characterization of two beta-ketoacyl-acyl carrier protein synthase I genes from Jatropha curcas L.
J. Plant Physiol.
214
152-160
2017
Jatropha curcas
Milligan, J.C.; Lee, D.J.; Jackson, D.R.; Schaub, A.J.; Beld, J.; Barajas, J.F.; Hale, J.J.; Luo, R.; Burkart, M.D.; Tsai, S.C.
Molecular basis for interactions between an acyl carrier protein and a ketosynthase
Nat. Chem. Biol.
15
669-671
2019
Escherichia coli (P0A953)
Yuan, Y.; Liang, Y.; Li, B.; Zheng, Y.; Luo, X.; Dongdong, L.
Cloning and function characterization of a beta-ketoacyl-acyl-ACP synthase I from coconut (Cocos nucifera L.) endosperm
Plant Mol. Biol. Rep.
33
1131-1140
2015
Cocos nucifera (V9N3I8)
-
Patterson, E.I.; Nanson, J.D.; Abendroth, J.; Bryan, C.; Sankaran, B.; Myler, P.J.; Forwood, J.K.
Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites
Proteins
88
47-56
2020
Brucella melitensis (Q2YQQ9), Brucella melitensis 2308 (Q2YQQ9)
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