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2.3.1.39: [acyl-carrier-protein] S-malonyltransferase

This is an abbreviated version!
For detailed information about [acyl-carrier-protein] S-malonyltransferase, go to the full flat file.

Word Map on EC 2.3.1.39

Reaction

malonyl-CoA
+
an [acyl-carrier protein]
=
CoA
 +
a malonyl-[acyl-carrier protein]

Synonyms

EtMCAT, FabD, FabD2, FAS, fatty acid synthase, HpMCAT, malonyl CoA-ACP malonyltransferase, malonyl CoA-ACP transacylase, malonyl CoA-acyl carrier protein transacylase, malonyl coenzyme A-acyl carrier protein transacylase, malonyl coenzyme A:acyl carrier protein transacylase, malonyl transacylase, malonyl transferase, malonyl-CoA acyl carrier protein transacylase, malonyl-CoA-acyl carrier protein transacylase, malonyl-CoA/ACP transacylase, malonyl-CoA/holo-ACP transacylase, malonyl-CoA: ACP transacylase, malonyl-CoA:ACP transacylase, malonyl-CoA:AcpM transacylase, malonyl-CoA:acyl carrier protein transacylase, malonyl-CoA:acyl-carrier protein transacylase, malonyl-CoA–acyl carrier protein transacylase, malonyl-coenzyme A (CoA)/holo-ACP transacylase, malonyl-coenzyme A-holo-acyl-carrier protein transacylase, malonyl-coenzyme A: acyl-carrier protein transacylase, malonyl-coenzyme A:ACP transacylase, malonyl-coenzymeA:acyl-carrier protein transacylase, malonyltransferase, [acyl-carrier-protein], MAT, MCAMT, MCAT, MCT, MdcH, More, mtFabD, SaMCAT, SpnMCAT, XoMCAT, [acyl carrier protein]malonyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.39 [acyl-carrier-protein] S-malonyltransferase

Inhibitors

Inhibitors on EC 2.3.1.39 - [acyl-carrier-protein] S-malonyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetoacetyl-CoA
-
inhibition of both isozymes at 0.02 mM and at 0.1 mM
acetyl-CoA
apomorphine
-
-
CaCl2
-
1 mM, 17% inhibition
corytuberine
diethyldicarbonate
-
inhibits MCT1 but not MCT2 at 1 mM
EDTA
-
63% inhibition at 1 mM, complete inhibition at 10 mM
iodoacetamide
iodoacetate
-
-
isoniazid
-
acts synergistically with trifluoroperazine
magnoflorine
-
-
malonyl-CoA
-
inhibition of MCT1 at 0.01 mM and inhibition of both isozymes at 0.02 mM and 0.04 mM; inhibits both MCT1 and MCT2
methylmalonyl-CoA
-
inhibition of MCT1 at 0.1 mM
MgCl2
-
1 mM, 34% inhibition
MnCl2
-
1 mM, 7% inhibition
N-ethylmaleimide
NiSO4
-
1 mM, 12% inhibition
p-chloromercuribenzoate
p-toluenesulfonyl fluoride
-
strong inhibitor
phenylmethanesulfonyl fluoride
propionyl-CoA
-
inhibition of both isozymes at 0.1 mM
reduced CoA
-
inhibition of both isozymes at 0.1 mM
succinyl-CoA
-
inhibition of MCT2 at 0.02 mM and inhibition of both isozymes at 0.1 mM
sulfhydryl compounds
trifluoroperazine
-
acts as calmodulin-antagonist in animals, inhibits mycobacterial lipid synthesis, acts synergistically with isoniazid
additional information
-