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2.3.1.39: [acyl-carrier-protein] S-malonyltransferase

This is an abbreviated version!
For detailed information about [acyl-carrier-protein] S-malonyltransferase, go to the full flat file.

Word Map on EC 2.3.1.39

Reaction

malonyl-CoA
+
an [acyl-carrier protein]
=
CoA
 +
a malonyl-[acyl-carrier protein]

Synonyms

EtMCAT, FabD, FabD2, FAS, fatty acid synthase, HpMCAT, malonyl CoA-ACP malonyltransferase, malonyl CoA-ACP transacylase, malonyl CoA-acyl carrier protein transacylase, malonyl coenzyme A-acyl carrier protein transacylase, malonyl coenzyme A:acyl carrier protein transacylase, malonyl transacylase, malonyl transferase, malonyl-CoA acyl carrier protein transacylase, malonyl-CoA-acyl carrier protein transacylase, malonyl-CoA/ACP transacylase, malonyl-CoA/holo-ACP transacylase, malonyl-CoA: ACP transacylase, malonyl-CoA:ACP transacylase, malonyl-CoA:AcpM transacylase, malonyl-CoA:acyl carrier protein transacylase, malonyl-CoA:acyl-carrier protein transacylase, malonyl-CoA–acyl carrier protein transacylase, malonyl-coenzyme A (CoA)/holo-ACP transacylase, malonyl-coenzyme A-holo-acyl-carrier protein transacylase, malonyl-coenzyme A: acyl-carrier protein transacylase, malonyl-coenzyme A:ACP transacylase, malonyl-coenzymeA:acyl-carrier protein transacylase, malonyltransferase, [acyl-carrier-protein], MAT, MCAMT, MCAT, MCT, MdcH, More, mtFabD, SaMCAT, SpnMCAT, XoMCAT, [acyl carrier protein]malonyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.39 [acyl-carrier-protein] S-malonyltransferase

Engineering

Engineering on EC 2.3.1.39 - [acyl-carrier-protein] S-malonyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K195A/K200A
the mutation results in a dramatic decrease in acyl-carrier protein binding
H91A/S92A
inactive
K61A
-
complete loss of the malonyl transferase activities
Q66A
-
complete loss of the malonyl transferase activities
Q66G
-
complete loss of the malonyl transferase activities
Q66R
-
increase in the malonyl transferase activities
R117A
L81R
-
the mutation is responsible for autosomal recessive optic neuropathy
L81R/R212W
-
the mutation is responsible for autosomal recessive optic neuropathy
R212W
-
the mutation is responsible for autosomal recessive optic neuropathy
R606A
H90A
Km only slightly increased compared to wild-type but Vmax strongly decreased compared to wild-type
H90A/N155A
lowest enzymatic activity
N155A
Km only slightly increased compared to wild-type but Vmax strongly decreased compared to wild-type
H90A
-
Km only slightly increased compared to wild-type but Vmax strongly decreased compared to wild-type
-
H90A/N155A
-
lowest enzymatic activity
-
N155A
-
Km only slightly increased compared to wild-type but Vmax strongly decreased compared to wild-type
-
E20A
-
mutant retains activity
K62A
-
complete loss of the malonyl transferase activities
Q67A
-
complete loss of the malonyl transferase activities
Q67G
-
complete loss of the malonyl transferase activities
Q67R
-
increase in the malonyl transferase activities
T65A
-
mutant retains activity
F198S
-
mutant shows a reduction in activity
H199A
-
mutant shows a drastic reduction in activity
L89A
-
mutant shows almost the same activity as wild-type
N158A
-
mutant shows almost the same activity as wild-type
R115A
-
mutant shows a reduction in activity
A197D
-
site-directed mutagenesis, reduced activity compared to the wild-type enzyme
F200A
-
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme
F200S
-
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme
F200Y
-
site-directed mutagenesis, reduced activity compared to the wild-type enzyme
G198A
-
site-directed mutagenesis, reduced activity compared to the wild-type enzyme
G198Y
-
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme
M126I
-
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme
M137L
-
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme
Q9A
-
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme
R122A
-
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme
R122K
-
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme
T57V
-
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme
V98Q
-
site-directed mutagenesis, reduced activity compared to the wild-type enzyme
F187A
site-directed mutagenesis, the mutant shows loss of about 65-70% activity compared to the wild-type enzyme
H188A
site-directed mutagenesis, inactive mutant
H87A
site-directed mutagenesis, the mutant shows loss of about 80% activity compared to the wild-type enzyme
Q10A
site-directed mutagenesis, the mutant shows loss of about 70% activity compared to the wild-type enzyme
R113A
site-directed mutagenesis, inactive mutant
S88T
site-directed mutagenesis, the mutant initializes the reaction by H87 deprotonating S88T which is different from the wild-type, loss of 10% activity compared to the wild-type enzyme
T56A
site-directed mutagenesis, the mutant shows loss of about 60% activity compared to the wild-type enzyme
additional information