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2.3.1.38: [acyl-carrier-protein] S-acetyltransferase

This is an abbreviated version!
For detailed information about [acyl-carrier-protein] S-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.38

Reaction

acetyl-CoA
+
an [acyl-carrier protein]
=
CoA
 +
an acetyl-[acyl-carrier protein]

Synonyms

ACAT, acetyl coenzyme A-acyl-carrier-protein transacylase, acetyl coenzyme A:ACP transacylase, acetyl-CoA-ACP-transacylase, acetyl-CoA:ACP transacylase, acetyl-CoA:acyl carrier protein transacylase, acetyltransferase, [acyl-carrier-protein], ACT, acyl-CoA:ACP transacylase, malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase, More, [ACP] acetyltransferase, [acyl-carrier-protein]acetyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.38 [acyl-carrier-protein] S-acetyltransferase

Engineering

Engineering on EC 2.3.1.38 - [acyl-carrier-protein] S-acetyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C159A
-
no activity
C59S
-
no activity
R606A
-
oligonucleotide-directed in vitro mutagenesis, 6.6fold increase in activity about 16000fold increase in selectivity for acetyl-CoA against malonyl-CoA, increased production of medium-chain length fatty acids
R606K
-
oligonucleotide-directed in vitro mutagenesis, 1.7fold increase in activity about 16fold increase in selectivity for acetyl-CoA against malonyl-CoA
S581A
-
nearly no remaining activity, below 0.03% compared to wild-type
C92S
-
no remaining activity acetyl-CoA:acyl carrier protein transacylase activity, but remaining strongly reduced thiolase activity