2.3.1.32: lysine N-acetyltransferase
This is an abbreviated version!
For detailed information about lysine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.32
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2.3.1.32
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coactivator
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chromatin
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transactivation
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e1a
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creb-binding
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gnat
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adenovirus
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oncoproteins
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deacetylases
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hdacs
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nucleosomal
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creb
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hypoxia-inducible
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deacetylation
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element-binding
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bromodomains
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p300-mediated
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smads
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hyperacetylation
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acetylase
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trichostatin
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h3k27ac
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corepressors
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non-histone
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p300-dependent
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accoa
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p53-dependent
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myod
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p53-mediated
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tax
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htlv-1
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medicine
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brd4
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pharmacology
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tata-binding
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selangor
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h3k4me1
- 2.3.1.32
-
coactivator
- chromatin
-
transactivation
- e1a
-
creb-binding
-
gnat
- adenovirus
- oncoproteins
- deacetylases
- hdacs
-
nucleosomal
- creb
-
hypoxia-inducible
-
deacetylation
-
element-binding
-
bromodomains
-
p300-mediated
- smads
-
hyperacetylation
-
acetylase
-
trichostatin
-
h3k27ac
-
corepressors
-
non-histone
-
p300-dependent
- accoa
-
p53-dependent
- myod
-
p53-mediated
- tax
- htlv-1
- medicine
- brd4
- pharmacology
-
tata-binding
-
selangor
-
h3k4me1
Reaction
Synonyms
acetyltransferase p300, acetyltransferase, lysine, ATase1, ATase2, Cbp, cyclic adenosine monophosphate response element-binding binding protein, Esa1, Gcn5, GCN5-A, GCN5-related N-acetyltransferase, GNAT, H4 lysine acetyltransferase, HAT, histone/protein lysine acetyltransferase, KAT, lysine acetyltransferase, NuA4, p/CAF, p300, p300 acetyltransferase, p300/CBP, PCAF, Rtt109 histone acetyltransferase, SePat
ECTree
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General Information
General Information on EC 2.3.1.32 - lysine N-acetyltransferase
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malfunction
metabolism
beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is acetylated in seven lysine residues that face the lumen of the ER and ER Golgi intermediate compartment (ERGIC)
physiological function
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dysfunction is associated with diseases like asthma, cardiovascular disorders, diabetes, and cancer
malfunction
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dysfunction is associated with diseases like asthma, cardiovascular disorders, diabetes, and cancer
malfunction
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a TgGCN5-A null mutant is deficient in responding to alkaline pH, a common stress used to induce bradyzoite differentiation in vitro. A genome-wide analysis of the Toxoplasma transcriptional response to alkaline pH stress shows that parasites deleted for TgGCN5-A fail to up-regulate 74% of the stress response genes that are induced 2fold or more in wild-type. TgGCN5-A knockout is also incapable of up-regulating key marker genes expressed during development of the latent cyst form, and is impaired in its ability to recover from alkaline stress
malfunction
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acetyltransferase-deficient NuA4 mutants have defects in septin collar formation resulting in the development of elongated buds through the Swe1-dependent morphogenesis checkpoint
malfunction
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DELTAabl mutants of Methanococcus maripaludis no longer produced Nepsilon-acetyl-beta-lysine and are incapable of growth at high salt concentrations, indicating that the abl operon is essential for Nepsilon-acetyl-beta-lysine synthesis
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Esa1 mediates increased H4 acetylation and enhanced chromatin remodeling complex RSC occupancy and histone eviction in coding sequences and stimulates the rate of transcription elongation by polymerase II
physiological function
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specific lysine 158 and lysine 287 acetylation of RIP140 (receptor-interacting protein 140) which is a co-regulator for many transcription factors, acetylation directly enhances the regulator's trans-repressive activity, role in fat accumulation
physiological function
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transcriptional regulation via histone complex acetylation, possibility of longer chain acyl-CoA transfers is proposed for histone acetyltransferases
physiological function
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transcriptional regulation via histone complex acetylation, possibility of longer chain acyl-CoA transfers is proposed for histone acetyltransferases
physiological function
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the enzyme is involved in the biosynthesis of Nepsilon-acetyl-beta-lysine, that is accumulated in the cells to respond to an osmotic upshock
physiological function
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the enzyme is involved in the biosynthesis of Nepsilon-acetyl-beta-lysine, that is accumulated in the cells to respond to an osmotic upshock
physiological function
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the acetyltransferases cyclic adenosine monophosphate response element-binding binding protein (CBP) and acetyltransferase p300 attenuate transcriptional activity of the mineralocorticoid receptor through its acetylation
physiological function
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the enzyme is involved in the biosynthesis of Nepsilon-acetyl-beta-lysine, that is accumulated in the cells to respond to an osmotic upshock
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