2.3.1.31: homoserine O-acetyltransferase

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For detailed information about homoserine O-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetyltransferase, homoserine, CnHTA, DcsE, HAT, homoserine acetyltransferase, homoserine O-acetyltransferase, homoserine transacetylase, homoserine transsuccinylase, homoserine-O-transacetylase, HTA, HTS, L-homoserine O-acetyltransferase, MaHTA, MaMetX, MET2, MetA, MetX, MetXA, metX_1, metX_2, MhHTA, MhMetX, MsHAT, MtHTA, MtMetX, TmHTS

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.31 homoserine O-acetyltransferase

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Results	in table
20179	AA Sequence
3	Application
1	CAS Registry Number
18	Cloned(Commentary)
5	Cofactor
10	Crystallization (Commentary)
64	General Information
1	General Stability
2	IC50 Value
30	Inhibitors
26	kcat/KM [mM/s]
6	Ki Value [mM]
98	KM Value [mM]
7	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
41	Organism
5	Pathway
32	PDB ID
12	pH Optimum
2	pH Range
1	pH Stability
75	Protein Variants
15	Purification (Commentary)
7	Reaction
1	Reaction Type
41	Reference
6	Specific Activity [micromol/min/mg]
1	Storage Stability
75	Substrates and Products (Substrate)
8	Subunits
95	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
3	Temperature Stability [°C]
60	Turnover Number [1/s]

Application

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Application on EC 2.3.1.31 - homoserine O-acetyltransferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

Mycobacterium tuberculosis

P9WJY9

possibilty to target the methionine biosynthesis pathway, which is not part of the host metabolism, through inhibition of the enzyme, structure-based drug design

758449

medicine

Cryptococcus neoformans

-

using a mouse inhalation model of infection it is shown that MET2 is required for virulence, making fungal HTA a viable target for new antibiotic discovery

684480

molecular biology

Fusarium graminearum

-

the HOA gene can be used as a selectable marker for transformation of Gibberella zeae

658488