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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
acetyl-CoA + L-threonine
CoA + O-acetyl-L-threonine
L-serine + acetyl-CoA
O-acetyl serine + CoA
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subsequently, cysteine synthase forms L-cysteine from O-acetyl serine
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L-serine + acetyl-CoA
O-acetyl-L-serine + CoA
L-serine + acetyl-CoA
O-acetylserine + CoA
no major contribution to total cysteine biosynthesis
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propionyl-CoA + L-serine
CoA + O-propionyl-L-serine
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additional information
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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
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acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
key enzyme in L-cysteine biosynthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
rate-limiting step of cysteine biosynthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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regulatory role in cysteine biosynthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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regulatory role in cysteine biosynthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
regulatory role in cysteine biosynthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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the complex array of compartment-specific SATase isoforms with distinct enzymatic properties and expression patterns ensures the provision of Cys in response to revelopmental and environmental changes
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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cysteine biosynthesis in plants is partly regulated by the physical association of O-acetylserine sulfhydrylase and serine acetyltransferase. Thermodynamics of the interaction is analyzed
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
each serine acetyltransferase isoform seems to have its specific role for cysteine biosynthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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simultaneous expression of serine acetyltransferase and cysteine synthase results in enhanced sulfate uptake and increased biomass in Ipomaea aquatica
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
O13389
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme is involved in cysteine biosynthesis. Increase in cysteine production confers enhanced resistance against osmotic stress in the osmosensitive yeast strain. Cysteine biosynthesis is a limiting factor in osmotic stress tolerance in yeast
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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dependent on L-serine and acetyl-CoA
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
regulatory role in cysteine biosynthesis
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme activity is sensitive to feedback inhibition by L-cysteine. Enzyme synthesis is repressed by L-methionine. Corynebacterium glutamicum synthesizes L-cysteine from L-serine via O-acetyl-L-serine through the pathway involving L-serineO-acetyltransferase and O-acetyl-L-serine sulfhydrylase. The enzyme is regulated at both the transcriptional and posttranslational level
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
first step of L-cysteine synthesis
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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L-serine acetylation is an equilibrium ordered mechanism
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme catalyzes the committed step in the de novo synthesis of L-cysteine. Serine acetyltransferase is regulated by feedback inhibition by the end product L-cysteine, which acts by binding to the serine site in the active site and inducing a conformational change that prevents reactant binding
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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serine acetyltransferase is a key enzyme in the sulfur assimilation pathway and forms a bienzyme complex with O-acetylserine sulfhydrylase, the last enzyme in the cysteine biosynthetic pathway. Serine acetyltransferase can inhibit O-acetylserine sulfhydrylase catalytic activity with a double mechanism, the competition with O-acetylserine for binding to the enzyme active site and the stabilization of a closed conformation that is less accessible to the natural substrate
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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specific for L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme in metabolic pathway of sulfur from sulfide to methionine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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specific for L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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equilibrium constant in direction of L-serine acetylation
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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equilibrium constant in direction of L-serine acetylation
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
regulatory role in cysteine biosynthesis
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
key role in the sulfur assimilatory pathway
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
A0A3L6DLJ7
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acetyl-CoA + L-threonine
CoA + O-acetyl-L-threonine
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acetyl-CoA + L-threonine
CoA + O-acetyl-L-threonine
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0.5% of the activity with L-serine
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acetyl-CoA + L-threonine
CoA + O-acetyl-L-threonine
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0.5% of the activity with L-serine
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acetyl-CoA + L-threonine
CoA + O-acetyl-L-threonine
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no activity
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L-serine + acetyl-CoA
O-acetyl-L-serine + CoA
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L-serine + acetyl-CoA
O-acetyl-L-serine + CoA
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L-serine + acetyl-CoA
O-acetyl-L-serine + CoA
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L-serine + acetyl-CoA
O-acetyl-L-serine + CoA
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L-serine + acetyl-CoA
O-acetyl-L-serine + CoA
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L-serine + acetyl-CoA
O-acetyl-L-serine + CoA
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additional information
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cysteine synthase is a bienzyme complex build of serine acetyltransferase and O-acetylserine (thiol) lyase, no channeling of substrate within the complex
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additional information
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O13389
enzyme performs L-serine acetylation, but has evolutionary evolved from serine O-acetyltransferase, high DNA sequence homology with the latter
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additional information
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coenzyme A binds to the C-terminal region, making mostly hydrophobic contacts from the center of the active site extending up to the surface of the protein. There is no conformational difference in the enzyme between the apo and the substrate-bound states, indicating lock and key binding and the absence of an induced fit mechanism
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additional information
?
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coenzyme A binds to the C-terminal region, making mostly hydrophobic contacts from the center of the active site extending up to the surface of the protein. There is no conformational difference in the enzyme between the apo and the substrate-bound states, indicating lock and key binding and the absence of an induced fit mechanism
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additional information
?
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coenzyme A binds to the C-terminal region, making mostly hydrophobic contacts from the center of the active site extending up to the surface of the protein. There is no conformational difference in the enzyme between the apo and the substrate-bound states, indicating lock and key binding and the absence of an induced fit mechanism
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additional information
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multienzyme complex is formed between serine acetyltransferase and cysteine synthase possibly leading to metabolic channeling
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additional information
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ligand binding structures, overview
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additional information
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ligand binding structures, overview
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additional information
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no activity: O-acetylserine, O-acetylhomoserine
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additional information
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Saccharomyces cerevisiae has detectable activity of L-serine O-acetyltransferase, but synthesizes L-cysteine exclusively via cystathionine by cystathionine beta-synthase and cystathionine gamma-lyase. The enzyme cannot support L-cysteine biosynthesis in vivo either because of very low activity or localization
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additional information
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serine acetyltransferase activity of CysE protein is detected by both DTNB [5,5'-dithiobis-(2-nitrobenzoic acid)] colorimetric assay and HPLC assay. Post-docking interactions between active site residues of protein (MRSA CysE) with ligand (L-Ser)
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additional information
?
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serine acetyltransferase activity of CysE protein is detected by both DTNB [5,5'-dithiobis-(2-nitrobenzoic acid)] colorimetric assay and HPLC assay. Post-docking interactions between active site residues of protein (MRSA CysE) with ligand (L-Ser)
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additional information
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the enzyme prefers L-serine as a substrate, but is also active with L-homoserine, EC 2.3.1.31, substrate specificity, overview
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additional information
?
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the enzyme prefers L-serine as a substrate, but is also active with L-homoserine, EC 2.3.1.31, substrate specificity, overview
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