2.3.1.30: serine O-acetyltransferase
This is an abbreviated version!
For detailed information about serine O-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.30
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2.3.1.30
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o-acetylserine
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sulfur
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l-cysteine
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sulfhydrylase
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o-acetyl-l-serine
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foot-and-mouth
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desulfhydrase
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oas-tls
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o-acetylserinethiollyase
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assimilatory
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slc26a1
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nasi-1
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thlaspi
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bienzyme
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phytochelatins
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molecular biology
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agriculture
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drug development
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medicine
- 2.3.1.30
- o-acetylserine
- sulfur
- l-cysteine
-
sulfhydrylase
- o-acetyl-l-serine
- foot-and-mouth
- desulfhydrase
- oas-tls
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o-acetylserinethiollyase
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assimilatory
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slc26a1
-
nasi-1
- thlaspi
-
bienzyme
- phytochelatins
- molecular biology
- agriculture
- drug development
- medicine
Reaction
Synonyms
acetyltransferase, serine, AtOASS, AtSAT, AtSAT1, AtSerat 2;1, BvSAT, CysE, cytosolic serine acetyltransferase, DcsE, EhSAT1, EhSAT2, EhSAT3, GmSerat2,1, HISAT, Kpn CysE, L-serine acetyltransferase, L-serine O-acetyltransferase, L-serineO-acetyltransferase, More, plastidic serine acetyltransferase, SAT, SAT isoform 1, SAT-1, SAT1, SAT2, SAT3, SATase, SERAT, Serat1,1, SERAT1.1, Serat2,1, Serat2,2, SERAT2.1, Serat3,1, Serat3,2, serine acetlytransferase, serine acetyltransferase, serine acetyltransferase 1, serine acetyltransferase 2,1, serine O-acetyltransferase, serine O-acetyltransferase 1, serine transacetylase, Spn cysE, SP_0589
ECTree
2.3.1.30 serine O-acetyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.30 - serine O-acetyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + L-Ser
CoA + O-acetyl-L-Ser
key enzyme in L-cysteine biosynthesis
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-
?
L-serine + acetyl-CoA
O-acetyl serine + CoA
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subsequently, cysteine synthase forms L-cysteine from O-acetyl serine
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?
L-serine + acetyl-CoA
O-acetylserine + CoA
no major contribution to total cysteine biosynthesis
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
rate-limiting step of cysteine biosynthesis
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
regulatory role in cysteine biosynthesis
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?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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regulatory role in cysteine biosynthesis
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
regulatory role in cysteine biosynthesis
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
key role in the sulfur assimilatory pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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the complex array of compartment-specific SATase isoforms with distinct enzymatic properties and expression patterns ensures the provision of Cys in response to revelopmental and environmental changes
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-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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cysteine biosynthesis in plants is partly regulated by the physical association of O-acetylserine sulfhydrylase and serine acetyltransferase. Thermodynamics of the interaction is analyzed
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-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
each serine acetyltransferase isoform seems to have its specific role for cysteine biosynthesis
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-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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simultaneous expression of serine acetyltransferase and cysteine synthase results in enhanced sulfate uptake and increased biomass in Ipomaea aquatica
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-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme is involved in cysteine biosynthesis. Increase in cysteine production confers enhanced resistance against osmotic stress in the osmosensitive yeast strain. Cysteine biosynthesis is a limiting factor in osmotic stress tolerance in yeast
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-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
regulatory role in cysteine biosynthesis
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
key role in the sulfur assimilatory pathway
-
ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme activity is sensitive to feedback inhibition by L-cysteine. Enzyme synthesis is repressed by L-methionine. Corynebacterium glutamicum synthesizes L-cysteine from L-serine via O-acetyl-L-serine through the pathway involving L-serineO-acetyltransferase and O-acetyl-L-serine sulfhydrylase. The enzyme is regulated at both the transcriptional and posttranslational level
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-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
first step of L-cysteine synthesis
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-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
Escherichia coli B / ATCC 11303
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first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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enzyme catalyzes the committed step in the de novo synthesis of L-cysteine. Serine acetyltransferase is regulated by feedback inhibition by the end product L-cysteine, which acts by binding to the serine site in the active site and inducing a conformational change that prevents reactant binding
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-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
enzyme in metabolic pathway of sulfur from sulfide to methionine
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
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ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
-
r
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
-
ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
-
ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
-
r
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
regulatory role in cysteine biosynthesis
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
key role in the sulfur assimilatory pathway
-
ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
first enzyme in L-cysteine synthesis pathway
-
ir
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
-
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
-
key role in the sulfur assimilatory pathway
-
?
acetyl-CoA + L-serine
CoA + O-acetyl-L-serine
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-
-
?
additional information
?
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cysteine synthase is a bienzyme complex build of serine acetyltransferase and O-acetylserine (thiol) lyase, no channeling of substrate within the complex
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?
additional information
?
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O13389
enzyme performs L-serine acetylation, but has evolutionary evolved from serine O-acetyltransferase, high DNA sequence homology with the latter
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?
additional information
?
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multienzyme complex is formed between serine acetyltransferase and cysteine synthase possibly leading to metabolic channeling
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?
additional information
?
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Saccharomyces cerevisiae has detectable activity of L-serine O-acetyltransferase, but synthesizes L-cysteine exclusively via cystathionine by cystathionine beta-synthase and cystathionine gamma-lyase. The enzyme cannot support L-cysteine biosynthesis in vivo either because of very low activity or localization
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?
