2.3.1.250: [Wnt protein] O-palmitoleoyl transferase
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For detailed information about [Wnt protein] O-palmitoleoyl transferase, go to the full flat file.
Reaction
Synonyms
CG6205, MG61, Mom-1, Mporc, mPorcD, PORC, PORCN, porcupine, PPN, protein-serine O-palmitoleoyltransferase porcupine, Xporc
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 2.3.1.250 - [Wnt protein] O-palmitoleoyl transferase
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lipoprotein
primate-specific S-palmitoylation of PORCN at Cys187, fatty acylation of PORCN is not due to autopalmitoylation. The palmitoylation of the enzyme, a membrane-bound O-acyltransferase or MBOAT protein, partially regulates Wnt palmitoylation and signaling, overview. Loss of palmitoylation of PORCN results in a modest increase in Wnt signaling, suggesting a negative regulatory role for PORCN Cys187 fatty acylation
lipoprotein
the enzyme itself is palmitoylated, the palmitoylation of the membrane-bound O-acyltransferase, MBOAT protein, partially regulates Wnt palmitoylation and signaling, overview