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2.3.1.250: [Wnt protein] O-palmitoleoyl transferase

This is an abbreviated version!
For detailed information about [Wnt protein] O-palmitoleoyl transferase, go to the full flat file.

Word Map on EC 2.3.1.250

Reaction

(9Z)-hexadec-9-enoyl-CoA
+
[Wnt]-L-serine
=
CoA
+
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine

Synonyms

CG6205, MG61, Mom-1, Mporc, mPorcD, PORC, PORCN, porcupine, PPN, protein-serine O-palmitoleoyltransferase porcupine, Xporc

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.250 [Wnt protein] O-palmitoleoyl transferase

Engineering

Engineering on EC 2.3.1.250 - [Wnt protein] O-palmitoleoyl transferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C187A
site-directed mutagenesis, increase in Wnt signaling activity of about 1.5fold upon expression of PORCNC187A compared to wild-type PORCN
C375X
site-directed mutagenesis, mutations introduced in PORCN at either Cys375, Cys381 or Cys385, all situated on a predicted luminal loop projecting from transmembrane domain VII that contains the catalytic His341 resi­due, have detrimental effects on Wnt3a palmitoylation and signaling that are comparable to that of the catalytically dead H341A mutant
C381X
site-directed mutagenesis, mutations introduced in PORCN at either Cys375, Cys381 or Cys385, all situated on a predicted luminal loop projecting from transmembrane domain VII that contains the catalytic His341 resi­due, have detrimental effects on Wnt3a palmitoylation and signaling that are comparable to that of the catalytically dead H341A mutant
C385X
site-directed mutagenesis, mutations introduced in PORCN at either Cys375, Cys381 or Cys385, all situated on a predicted luminal loop projecting from transmembrane domain VII that contains the catalytic His341 resi­due, have detrimental effects on Wnt3a palmitoylation and signaling that are comparable to that of the catalytically dead H341A mutant
H341A
H341D
site-directed mutagenesis, catalytically inactive mutant
H341Q
site-directed mutagenesis, catalytically inactive mutant
additional information