2.3.1.244: 2-methylbutanoate polyketide synthase
This is an abbreviated version!
For detailed information about 2-methylbutanoate polyketide synthase, go to the full flat file.
Reaction
2 malonyl-CoA + + 2 NADPH + 3 H+ + = + 2 CoA + 2 CO2 + 2 NADP+ + +
Synonyms
LDKS, LocF, lovastatin diketide synthase, LovF
ECTree
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Systematic Name
Systematic Name on EC 2.3.1.244 - 2-methylbutanoate polyketide synthase
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acyl-CoA:malonyl-CoA C-acyltransferase (2-methylbutanoate-forming)
This polyketide synthase enzyme forms the (S)-2-methylbutanoate side chain during lovastatin biosynthesis by the filamentous fungus Aspergillus terreus. The overall reaction comprises a single condensation reaction followed by alpha-methylation, beta-ketoreduction, dehydration, and alpha,beta-enoyl reduction.