2.3.1.244: 2-methylbutanoate polyketide synthase
This is an abbreviated version!
For detailed information about 2-methylbutanoate polyketide synthase, go to the full flat file.
Reaction
2 malonyl-CoA + + 2 NADPH + 3 H+ + = + 2 CoA + 2 CO2 + 2 NADP+ + +
Synonyms
LDKS, LocF, lovastatin diketide synthase, LovF
ECTree
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General Information
General Information on EC 2.3.1.244 - 2-methylbutanoate polyketide synthase
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metabolism
physiological function
enzyme LovF synthesizes the alpha-S-methylbutyrate side chain that is subsequently transferred to monacolin J to yield the cholesterol-lowering natural product lovastatin. The diketide product of LovF is offloaded from the LovF acyl carrier protein domain by the dissociated acyltransferase LovD. LovD primarily interacts with the acyl carrier protein domain of LovF and the protein-protein interactions lead to highly efficient transfer of the diketide product. The catalytic efficiency is enhanced nearly one millionfold when LovF is used as the acyl carrier instead of N-acetylcysteamine
the enzyme is involved in the lovastatin biosynthetic pathway