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2.3.1.244: 2-methylbutanoate polyketide synthase

This is an abbreviated version!
For detailed information about 2-methylbutanoate polyketide synthase, go to the full flat file.

Reaction

2 malonyl-CoA +

[2-methylbutanoate polyketide synthase]
+ 2 NADPH + 3 H+ +
S-adenosyl-L-methionine
=
(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]
+ 2 CoA + 2 CO2 + 2 NADP+ +
S-adenosyl-L-homocysteine
+
H2O

Synonyms

LDKS, LocF, lovastatin diketide synthase, LovF

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.244 2-methylbutanoate polyketide synthase

General Information

General Information on EC 2.3.1.244 - 2-methylbutanoate polyketide synthase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
a lovF mutant strain produces no lovastatin
metabolism
physiological function
enzyme LovF synthesizes the alpha-S-methylbutyrate side chain that is subsequently transferred to monacolin J to yield the cholesterol-lowering natural product lovastatin. The diketide product of LovF is offloaded from the LovF acyl carrier protein domain by the dissociated acyltransferase LovD. LovD primarily interacts with the acyl carrier protein domain of LovF and the protein-protein interactions lead to highly efficient transfer of the diketide product. The catalytic efficiency is enhanced nearly one millionfold when LovF is used as the acyl carrier instead of N-acetylcysteamine