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2.3.1.24: sphingosine N-acyltransferase

This is an abbreviated version!
For detailed information about sphingosine N-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.24

Reaction

an acyl-CoA
+
sphingosine
=
CoA
+
a ceramide

Synonyms

(dihydro)ceramide synthase, acyl-CoA : sphingosine N-acyltramferase, acyl-CoA : sphingosine N-acyltransferase, acyltransferase, sphingosine, C16:0-CerS, CER2, Cer3, ceramide synthase, ceramide synthase 4, ceramide synthase 5, ceramide synthase 6, ceramide synthetase, CerS, CerS4, CerS45, CerS5, CerS6, CNAG_02086, CNAG_02087, CNAG_06717, DLag1, Drosophila longevitiy assurance gene-1 homologue, fatty acyl-CoA:sphingosine acyltransferase, LAC1, LAG1, LAG1 longevity assurance homolog 2, LAG1 longevity assurance homolog 5, LAG12, LASS5, Lass6, LOH2, longevity assurance homolog 5, longevity assurance homolog 6, longevity assurance homologue 5, longevity assurance homologue 6, More, schlank, SpAT, sphinganine N-acyl transferase synthase, sphinganine N-acyltransferase, sphingosine acyltransferase, sphingosine N-acyltransferase, sphingosine/sphinganine acyltransferase, TcCerS, TcCERS1, TRAM homolog 4, translocating chain-associating membrane protein homolog 4, trh1-like, trh4

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.24 sphingosine N-acyltransferase

Reference

Reference on EC 2.3.1.24 - sphingosine N-acyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shimeno, H.; Soeda, S.; Sakamoto, M.; Kouchi, T.; Kowakame, T.; Kihara, T.
Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction
Lipids
33
601-605
1998
Bos taurus
Manually annotated by BRENDA team
Xu, Z.; Zhou, J.; McCoy, D.M.; Mallampalli, R.K.
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia
J. Lipid Res.
46
1229-1238
2005
Mus musculus (Q9D6K9), Mus musculus
Manually annotated by BRENDA team
Voss, K.A.; Norred, W.P.; Meredith, F.I.; Riley, R.T.; Stephen Saunders, D.
Fumonisin concentration and ceramide synthase inhibitory activity of corn, masa, and tortilla chips
J. Toxicol. Environ. Health A
69
1387-1397
2006
Chlorocebus aethiops
Manually annotated by BRENDA team
Figueiredo, J.M.; Rodrigues, D.C.; Silva, R.C.; Koeller, C.M.; Jiang, J.C.; Jazwinski, S.M.; Previato, J.O.; Mendonca-Previato, L.; Urmenyi, T.P.; Heise, N.
Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi
Mol. Biochem. Parasitol.
182
62-74
2012
Trypanosoma cruzi (G0YYC4), Trypanosoma cruzi
Manually annotated by BRENDA team
Tirodkar, T.S.; Lu, P.; Bai, A.; Scheffel, M.J.; Gencer, S.; Garrett-Mayer, E.; Bielawska, A.; Ogretmen, B.; Voelkel-Johnson, C.
Expression of ceramide synthase 6 transcriptionally activates acid ceramidase in a c-Jun N-terminal kinase (JNK)-dependent manner
J. Biol. Chem.
290
13157-13167
2015
Mus musculus (Q8C172)
Manually annotated by BRENDA team
Basnakian, A.G.; Ueda, N.; Hong, X.; Galitovsky, V.E.; Yin, X.; Shah, S.V.
Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation
Am. J. Physiol.
288
F308-F314
2005
Rattus norvegicus
Manually annotated by BRENDA team
Erez-Roman, R.; Pienik, R.; Futerman, A.H.
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression
Biochem. Biophys. Res. Commun.
391
219-223
2010
Homo sapiens (Q6ZMG9), Homo sapiens (Q9HA82), Homo sapiens
Manually annotated by BRENDA team
Hirschberg, K.; Rodger, J.; Futerman, A.H.
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver
Biochem. J.
290
751-757
1993
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Mizutani, Y.; Kihara, A.; Igarashi, Y.
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
Biochem. J.
390
263-271
2005
Mus musculus (Q8C172), Mus musculus (Q9D6K9), Mus musculus
Manually annotated by BRENDA team
Veret, J.; Coant, N.; Berdyshev, E.V.; Skobeleva, A.; Therville, N.; Bailbe, D.; Gorshkova, I.; Natarajan, V.; Portha, B.; Le Stunff, H.
Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 beta-cells
Biochem. J.
438
177-189
2011
Rattus norvegicus (D3ZU86)
Manually annotated by BRENDA team
Luttgeharm, K.D.; Cahoon, E.B.; Markham, J.E.
Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis
Biochem. J.
473
593-603
2016
Arabidopsis thaliana (Q9LJK3)
Manually annotated by BRENDA team
Sribney, M.
Enzymatic synthesis of ceramide
Biochim. Biophys. Acta
125
542-547
1966
Cavia porcellus, Gallus gallus
Manually annotated by BRENDA team
Sridevi, P.; Alexander, H.; Laviad, E.L.; Pewzner-Jung, Y.; Hannink, M.; Futerman, A.H.; Alexander, S.
Ceramide synthase 1 is regulated by proteasomal mediated turnover
Biochim. Biophys. Acta
1793
1218-1227
2009
Mus musculus (Q9D6K9)
Manually annotated by BRENDA team
Shimeno, H.; Soeda, S.; Yasukouchi, M.; Okamura, N.; Nagamatsu, A.
Fatty acyl-CoA sphingosine acyltransferase in bovine brain mitochondria its solubilization and reconstitution onto the membrane lipid liposomes
Biol. Pharm. Bull.
18
1335-1339
1995
Bos taurus (A0A3Q1MJ30), Bos taurus
Manually annotated by BRENDA team
Wang, H.; Maurer, B.J.; Reynolds, C.P.; Cabot, M.C.
N-(4-Hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase
Cancer Res.
61
5102-5105
2001
Homo sapiens
Manually annotated by BRENDA team
Bose, R.; Verheji, M.; Haimovitz-Friedman, A.; Scotto, K.; Fuks, Z.; Kolesnick, R.
Ceramide synthase mediates daunorubicin-induced apoptosis an alternative mechanism for generating death signals
Cell
82
405-414
1995
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Mesicek, J.; Lee, H.; Feldman, T.; Jiang, X.; Skobeleva, A.; Berdyshev, E.V.; Haimovitz-Friedman, A.; Fuks, Z.; Kolesnick, R.
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells
Cell. Signal.
22
1300-1307
2010
Homo sapiens (Q6ZMG9), Homo sapiens (Q8N5B7)
Manually annotated by BRENDA team
Bauer, R.; Voelzmann, A.; Breiden, B.; Schepers, U.; Farwanah, H.; Hahn, I.; Eckardt, F.; Sandhoff, K.; Hoch, M.
Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila
EMBO J.
28
3706-3716
2009
Drosophila melanogaster
Manually annotated by BRENDA team
Choi, S.; Snider, J.M.; Olakkengil, N.; Lambert, J.M.; Anderson, A.K.; Ross-Evans, J.S.; Cowart, L.A.; Snider, A.J.
Myristate-induced endoplasmic reticulum stress requires ceramide synthases 5/6 and generation of C14-ceramide in intestinal epithelial cells
FASEB J.
32
5724-5736
2018
Mus musculus (Q8C172), Mus musculus (Q9D6K9)
Manually annotated by BRENDA team
Wang, E.; Norred, W.P.; Bacon, C.W.; Riley, R.T.; Merrill, A.H.
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme
J. Biol. Chem.
266
14486-14490
1991
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Mandon, E.C.; Ehses, I.; Rother, J.; van Echten, G.; Sandhoff, K.
Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver
J. Biol. Chem.
267
11144-11148
1992
Mus musculus
Manually annotated by BRENDA team
Merrill, A.H.; van Echten, G.; Wang, E.; Sandhoff, K.
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ
J. Biol. Chem.
268
27299-27306
1993
Mus musculus, Mus musculus NMRI
Manually annotated by BRENDA team
Lahiri, S.; Park, H.; Laviad, E.L.; Lu, X.; Bittman, R.; Futerman, A.H.
Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner
J. Biol. Chem.
284
16090-16098
2009
Homo sapiens (Q8N5B7), Homo sapiens (Q9HA82)
Manually annotated by BRENDA team
Mullen, T.D.; Jenkins, R.W.; Clarke, C.J.; Bielawski, J.; Hannun, Y.A.; Obeid, L.M.
Ceramide synthase-dependent ceramide generation and programmed cell death involvement of salvage pathway in regulating postmitochondrial events
J. Biol. Chem.
286
15929-15942
2011
Homo sapiens (Q6ZMG9), Homo sapiens (Q8N5B7)
Manually annotated by BRENDA team
Laviad, E.L.; Kelly, S.; Merrill, A.H.; Futerman, A.H.
Modulation of ceramide synthase activity via dimerization
J. Biol. Chem.
287
21025-21033
2012
Homo sapiens (Q8N5B7)
Manually annotated by BRENDA team
Sassa, T.; Hirayama, T.; Kihara, A.
Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the C-terminal region
J. Biol. Chem.
291
7477-7487
2016
Homo sapiens (Q8IU89), Homo sapiens (Q8N5B7), Homo sapiens (Q96G23), Homo sapiens (Q9HA82), Homo sapiens (Q9NTG7), Mus musculus (Q924Z4), Mus musculus
Manually annotated by BRENDA team
Xu, Z.; Zhou, J.; McCoy, D.M.; Mallampalli, R.K.
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia
J. Lipid Res.
46
1229-1238
2005
Mus musculus (Q9D6K9), Mus musculus, Mus musculus C57BL/6 (Q9D6K9)
Manually annotated by BRENDA team
Mizutani, Y.; Kihara, A.; Chiba, H.; Tojo, H.; Igarashi, Y.
2-Hydroxy-ceramide synthesis by ceramide synthase family enzymatic basis for the preference of FA chain length
J. Lipid Res.
49
2356-2364
2008
Homo sapiens (Q6ZMG9), Homo sapiens (Q8N5B7)
Manually annotated by BRENDA team
Shimeno, H.; Soeda, S.; Sakamoto, M.; Kouchi, T.; Kowakame, T.; Kihara, T.
Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction
Lipids
33
601-605
1998
Bos taurus (A0A3Q1MVP2), Bos taurus
Manually annotated by BRENDA team
Merrill, A.H.; Wang, E.
Enzymes of ceramide biosynthesis
Methods Enzymol.
209
427-437
1992
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Lim, X.Y.; Pickford, R.; Don, A.S.
Assaying ceramide synthase activity in vitro and in living cells using liquid chromatography-mass spectrometry
Methods Mol. Biol.
1376
11-22
2016
Homo sapiens (Q6ZMG9), Homo sapiens (Q8N5B7), Homo sapiens (Q9HA82)
Manually annotated by BRENDA team
White-Gilbertson, S.; Mullen, T.; Senkal, C.; Lu, P.; Ogretmen, B.; Obeid, L.; Voelkel-Johnson, C.
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells
Oncogene
28
1132-1141
2009
Homo sapiens (Q6ZMG9)
Manually annotated by BRENDA team
Sharma, S.; Ahmed, M.; Akhter, Y.
The revelation of selective sphingolipid pathway inhibition mechanism on fumonisin toxin binding to ceramide synthases in susceptible organisms and survival mechanism in resistant species
Biochimie
149
41-50
2018
Trichoderma guizhouense (A0A1T3CVR0), Trichoderma guizhouense, Saccharomyces cerevisiae (P38703), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Munshi, M.; Gardin, J.; Singh, A.; Luberto, C.; Rieger, R.; Bouklas, T.; Fries, B.; Del Poeta, M.
The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans
Cell Rep.
22
1392-1400
2018
Cryptococcus neoformans var. grubii (J9VFF7), Cryptococcus neoformans var. grubii (J9VMM2), Cryptococcus neoformans var. grubii (J9VQN5)
Manually annotated by BRENDA team
Williams, B.; Correnti, J.; Oranu, A.; Lin, A.; Scott, V.; Annoh, M.; Beck, J.; Furth, E.; Mitchell, V.; Senkal, C.E.; Obeid, L.; Carr, R.M.
A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis
FASEB J.
32
130-142
2018
Homo sapiens (Q6ZMG9), Homo sapiens, Mus musculus (Q8C172), Mus musculus
Manually annotated by BRENDA team
Kim, M.H.; Ahn, H.K.; Lee, E.J.; Kim, S.J.; Kim, Y.R.; Park, J.W.; Park, W.J.
Hepatic inflammatory cytokine production can be regulated by modulating sphingomyelinase and ceramide synthase 6
Int. J. Mol. Med.
39
453-462
2017
Mus musculus (Q8C172)
Manually annotated by BRENDA team
Tidhar, R.; Zelnik, I.; Volpert, G.; Ben-Dor, S.; Kelly, S.; Merrill, A.; Futerman, A.
Eleven residues determine the acyl chain specificity of ceramide synthases
J. Biol. Chem.
293
9912-9921
2018
Homo sapiens (Q8N5B7), Homo sapiens (Q9HA82)
Manually annotated by BRENDA team
Megyeri, M.; Prasad, R.; Volpert, G.; Sliwa-Gonzalez, A.; Haribowo, A.; Aguilera-Romero, A.; Riezman, H.; Barral, Y.; Futerman, A.; Schuldiner, M.
Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity
J. Cell Sci.
132
jcs228411
2019
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Couttas, T.; Don, A.
Fluorescent assays for ceramide synthase activity
Methods Mol. Biol.
1376
23-33
2016
Homo sapiens
Manually annotated by BRENDA team