2.3.1.24: sphingosine N-acyltransferase

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For detailed information about sphingosine N-acyltransferase, go to the full flat file.

Reaction

Synonyms

(dihydro)ceramide synthase, acyl-CoA : sphingosine N-acyltramferase, acyl-CoA : sphingosine N-acyltransferase, acyltransferase, sphingosine, C16:0-CerS, CER2, Cer3, ceramide synthase, ceramide synthase 4, ceramide synthase 5, ceramide synthase 6, ceramide synthetase, CerS, CerS4, CerS45, CerS5, CerS6, CNAG_02086, CNAG_02087, CNAG_06717, DLag1, Drosophila longevitiy assurance gene-1 homologue, fatty acyl-CoA:sphingosine acyltransferase, LAC1, LAG1, LAG1 longevity assurance homolog 2, LAG1 longevity assurance homolog 5, LAG12, LASS5, Lass6, LOH2, longevity assurance homolog 5, longevity assurance homolog 6, longevity assurance homologue 5, longevity assurance homologue 6, More, schlank, SpAT, sphinganine N-acyl transferase synthase, sphinganine N-acyltransferase, sphingosine acyltransferase, sphingosine N-acyltransferase, sphingosine/sphinganine acyltransferase, TcCerS, TcCERS1, TRAM homolog 4, translocating chain-associating membrane protein homolog 4, trh1-like, trh4

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.24 sphingosine N-acyltransferase

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Results	in table
8	Activating Compound
136	AA Sequence
4	Application
1	CAS Registry Number
23	Cloned(Commentary)
2	Crystallization (Commentary)
583	Disease/ Diagnostics
5	Expression
63	General Information
1	General Stability
1	IC50 Value
36	Inhibitors
3	Ki Value [mM]
27	KM Value [mM]
35	Localization
12	Metals/Ions
4	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
393	Organism
5	Pathway
8	PDB ID
23	pH Optimum
6	pH Range
11	Posttranslational Modification
21	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
57	Reference
2	Renatured (Commentary)
80	Source Tissue
4	Specific Activity [micromol/min/mg]
118	Substrates and Products (Substrate)
6	Subunits
114	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]

Purification

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Purification on EC 2.3.1.24 - sphingosine N-acyltransferase

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Mus musculus

Q9D6K9

675259

n-octyl beta-D-thioglucoside, DE-32, sphingosine-celite, Sepharose CL-6B

Bos taurus

-

486668

native enzyme 98.7fold from liver mitochondrionrich fraction by solubilization with n-octyl beta-D-thioglucoside, ion exchange chromatography, sphingosine affinity chromatography, and gel filtration

Bos taurus

A0A3Q1MVP2

754575

recombinant His-tagged LASS5 from MLE cells by nickel affinity chromatography and ultrafiltration

Mus musculus

Q9D6K9

754360

solubilization of membrane-bound enzyme from brain mitochondria by 2% of Trinton X-100, followed by ammonium sulfate fractionation and dialysis

Bos taurus

A0A3Q1MJ30

752899

subcellular fractionation of HeLa cells recombinantly expressing the CerS isozyme

Homo sapiens

Q6ZMG9, Q8N5B7

753223