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2.3.1.24: sphingosine N-acyltransferase

This is an abbreviated version!
For detailed information about sphingosine N-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.24

Reaction

an acyl-CoA
+
sphingosine
=
CoA
 +
a ceramide

Synonyms

(dihydro)ceramide synthase, acyl-CoA : sphingosine N-acyltramferase, acyl-CoA : sphingosine N-acyltransferase, acyltransferase, sphingosine, C16:0-CerS, CER2, Cer3, ceramide synthase, ceramide synthase 4, ceramide synthase 5, ceramide synthase 6, ceramide synthetase, CerS, CerS4, CerS45, CerS5, CerS6, CNAG_02086, CNAG_02087, CNAG_06717, DLag1, Drosophila longevitiy assurance gene-1 homologue, fatty acyl-CoA:sphingosine acyltransferase, LAC1, LAG1, LAG1 longevity assurance homolog 2, LAG1 longevity assurance homolog 5, LAG12, LASS5, Lass6, LOH2, longevity assurance homolog 5, longevity assurance homolog 6, longevity assurance homologue 5, longevity assurance homologue 6, More, schlank, SpAT, sphinganine N-acyl transferase synthase, sphinganine N-acyltransferase, sphingosine acyltransferase, sphingosine N-acyltransferase, sphingosine/sphinganine acyltransferase, TcCerS, TcCERS1, TRAM homolog 4, translocating chain-associating membrane protein homolog 4, trh1-like, trh4

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.24 sphingosine N-acyltransferase

Expression

Expression on EC 2.3.1.24 - sphingosine N-acyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
CerS6 is upregulated in alcoholic steatosis
CerS6 is upregulated in alcoholic steatosis and in response to ethanol
ionizing radiation (IR) induces de novo synthesis of ceramide by specifically activating CerS isoforms 2, 5, and 6
palmitate increases the levels of CerS4 mRNA 3fold in the presence of 30 mM glucose, overview
UV-C irradiation decreases the expression of CerS5 enzyme by about 50%