2.3.1.24: sphingosine N-acyltransferase

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For detailed information about sphingosine N-acyltransferase, go to the full flat file.

Reaction

Synonyms

(dihydro)ceramide synthase, acyl-CoA : sphingosine N-acyltramferase, acyl-CoA : sphingosine N-acyltransferase, acyltransferase, sphingosine, C16:0-CerS, CER2, Cer3, ceramide synthase, ceramide synthase 4, ceramide synthase 5, ceramide synthase 6, ceramide synthetase, CerS, CerS4, CerS45, CerS5, CerS6, CNAG_02086, CNAG_02087, CNAG_06717, DLag1, Drosophila longevitiy assurance gene-1 homologue, fatty acyl-CoA:sphingosine acyltransferase, LAC1, LAG1, LAG1 longevity assurance homolog 2, LAG1 longevity assurance homolog 5, LAG12, LASS5, Lass6, LOH2, longevity assurance homolog 5, longevity assurance homolog 6, longevity assurance homologue 5, longevity assurance homologue 6, More, schlank, SpAT, sphinganine N-acyl transferase synthase, sphinganine N-acyltransferase, sphingosine acyltransferase, sphingosine N-acyltransferase, sphingosine/sphinganine acyltransferase, TcCerS, TcCERS1, TRAM homolog 4, translocating chain-associating membrane protein homolog 4, trh1-like, trh4

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.24 sphingosine N-acyltransferase

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Results	in table
8	Activating Compound
136	AA Sequence
4	Application
1	CAS Registry Number
23	Cloned(Commentary)
2	Crystallization (Commentary)
583	Disease/ Diagnostics
5	Expression
63	General Information
1	General Stability
1	IC50 Value
36	Inhibitors
3	Ki Value [mM]
27	KM Value [mM]
35	Localization
12	Metals/Ions
4	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
393	Organism
5	Pathway
8	PDB ID
23	pH Optimum
6	pH Range
11	Posttranslational Modification
21	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
57	Reference
2	Renatured (Commentary)
80	Source Tissue
4	Specific Activity [micromol/min/mg]
118	Substrates and Products (Substrate)
6	Subunits
114	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]

Application

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Application on EC 2.3.1.24 - sphingosine N-acyltransferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Homo sapiens

-

fluorescent CERS assay with quantification using thin-layer chromatography or high-performance liquid chromatography

757588

diagnostics

Homo sapiens

Q6ZMG9, Q9HA82

important role for the CerS genes in breast cancer etiology or diagnosis, overview

752644

medicine

2 entries

medicine

Homo sapiens

Q6ZMG9

isoform CerS6 is specifically upregulated in experimental alcoholic steatosis in vivo and in vitro

756688

medicine

Mus musculus

Q8C172

isoform CerS6 is specifically upregulated in experimental alcoholic steatosis in vivo and in vitro. In vivo ceramide reduction by inhibition of de novo ceramide synthesis reduces PLIN2 and hepatic steatosis in alcohol-fed mice, and improves glucose homeostasis in control and Etoh mice, but only de novo synthesis inhibition. Inhibition of ceramide synthesis during alcohol feeding has minimal effect on body composition, food intake, and energy expenditure

756688