2.3.1.236: 5-methylnaphthoic acid synthase

This is an abbreviated version!
For detailed information about 5-methylnaphthoic acid synthase, go to the full flat file.

Reaction

Synonyms

5-methyl-naphthoic acid synthase, AziB, NPA synthase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.236 5-methylnaphthoic acid synthase

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Results	in table
3	AA Sequence
2	Cloned(Commentary)
1	General Information
1	Natural Substrates/ Products (Substrates)
3	Organism
1	Protein Variants
1	Reaction
3	Reference
4	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 2.3.1.236 - 5-methylnaphthoic acid synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+

5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+

4 entries

acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+

5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+

Streptomyces sahachiroi

B4XYB8

-

729575

-

-

?

acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+

5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+

Streptomyces sahachiroi

B4XYB8

-

735692

incubation of substrates with isoform AziB alone leads to a truncated single-ring product, 2-methylbenzoic acid. Presence of thioesterase AziG acting as a chain elongation and cyclization domain is required for additional two rounds of chain extension to form the expected product, 5-methyl-1-naphthoate. None of the other thioesterase domains (AziA6, AziA7, AziA8) are capable of catalyzing the reaction

-

?

acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+

5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+

Streptomyces sahachiroi

B4XYB8

the multi-domain polyketide synthase involved in the synthesis of azinomycin B

729575

-

-

?

acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+

5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+

Streptomyces sahachiroi NRRL 2485

B4XYB8

-

735692

incubation of substrates with isoform AziB alone leads to a truncated single-ring product, 2-methylbenzoic acid. Presence of thioesterase AziG acting as a chain elongation and cyclization domain is required for additional two rounds of chain extension to form the expected product, 5-methyl-1-naphthoate. None of the other thioesterase domains (AziA6, AziA7, AziA8) are capable of catalyzing the reaction

-

?