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2.3.1.236: 5-methylnaphthoic acid synthase

This is an abbreviated version!
For detailed information about 5-methylnaphthoic acid synthase, go to the full flat file.

Reaction

acetyl-CoA
+ 5 malonyl-CoA + 3 NADPH + 3 H+ =
5-methyl-1-naphthoate
+ 6 CoA + 5 CO2 + 4 H2O + 3 NADP+

Synonyms

5-methyl-naphthoic acid synthase, AziB, NPA synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.236 5-methylnaphthoic acid synthase

Cloned

Cloned on EC 2.3.1.236 - 5-methylnaphthoic acid synthase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
heterologous expression of aziB in Streptomyces albus. Addition of aziB1 (encoding a P450 hydroxylase) and aziB2 (encoding an O-methyltransferase) to aziB in Streptomyces albus allows for the production of 3-methoxy-5-methyl-naohthoic acid as the first building block for skeleton assembly of azinomycin B