2.3.1.22: 2-acylglycerol O-acyltransferase
This is an abbreviated version!
For detailed information about 2-acylglycerol O-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.22
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2.3.1.22
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n-glycans
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mgats
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diacylglycerols
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triacylglycerol
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n-acetylglucosaminyltransferase
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bisect
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glcnac
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gnt-iii
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nipecotic
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glycome
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tiagabine
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acyl-coa:diacylglycerol
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medicine
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st6gal1
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drug development
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pharmacology
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analysis
- 2.3.1.22
- n-glycans
-
mgats
- diacylglycerols
- triacylglycerol
-
n-acetylglucosaminyltransferase
-
bisect
- glcnac
- gnt-iii
-
nipecotic
-
glycome
-
tiagabine
-
acyl-coa:diacylglycerol
- medicine
- st6gal1
- drug development
- pharmacology
- analysis
Reaction
Synonyms
acyl CoA:monoacylglycerol acyltransferase, acyl CoA:monoacylglycerol acyltransferase-2, acyl coenzyme A-monoglyceride acyltransferase, acyl coenzyme A:diacylglycerol acyltransferase, acyl-CoA:monoacylglycerol acyltransferase, acyl-CoA:monoacylglycerol transferase, acyl-coenzyme A:monoacylglycerol acyltransferase, acylglycerol palmitoyltransferase, DGAT, DGAT1/ARAT, diacylglycerol acyltransferase, GPAT4, LPGAT1, lysophosphatidylglycerol acyltransferase 1, MFAT, MGAT, MGAT1, Mgat2, MGAT3, MGOT1, MGOT2, MGOT3, MOGAT1, MOGAT2, MOGAT3, monoacylglycerol acyltransferase, monoacylglycerol acyltransferase-2, monoacylglycerol O-acyltransferase, monoacylglycerol O-acyltransferase 1, monoglyceride acyltransferase, More, multifunctional O-acyltransferase, OLE3, oleosin 3, palmitoyltransferase, acylglycerol, wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase, WS/DGAT, [acyl CoA]monoacylglycerol acyltransferase 2
ECTree
2.3.1.22 2-acylglycerol O-acyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.22 - 2-acylglycerol O-acyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-acyl-sn-glycerol + palmitoyl-CoA
diacylglycerol + CoA
-
in vitro assay in lysate of transfected CHO cells or of microsome preparation of mouse liver, 2-monoacylglycerol is preferred over 1-monoacylglycerol, 25°C, pH 6.4
-
-
?
acetyl-CoA + 2-oleoyl-(Z)-1-(octadec-9-enyl)glycerol
CoA + 2,3-dioleoyl-(Z)-1-(octadec-9-enyl)glycerol
-
-
-
?
acetyl-CoA + 3-oleoyl-(Z)-1-(octadec-9-enyl)glycerol
CoA + 2,3-dioleoyl-(Z)-1-(octadec-9-enyl)glycerol
-
-
-
?
acyl-CoA + 2-oleoylglycerol
CoA + 1-acyl-2-oleoylglycerol
deuterated substrate 2-oleoylglycerol-d5
-
-
?
acyl-CoA + sn-2-monolinolenoylglycerol
CoA + 1-acyl-2-linolenoylglycerol
-
in preference to sn-2-monooleoylglycerol
-
-
?
acyl-CoA + sn-2-monolinoleoylglycerol
CoA + 1-acyl-2-linoleoylglycerol
-
in preference to sn-2-monooleoylglycerol
-
-
?
arachidonoyl-CoA + sn-2-monooleoylglycerol
CoA + 1-arachidonoyl-2-oleoylglycerol
-
-
-
?
arachidoyl-CoA + sn-2-monooleoylglycerol
CoA + 1-arachidoyl-2-oleoylglycerol
-
-
-
?
lauroyl-CoA + sn-2-monooleoylglycerol
CoA + 1-lauroyl-2-oleoylglycerol
-
-
-
?
N-(7-nitro-2-1,3-benzoxadiazol-4-yl)amino-palmitoyl-CoA + 2-oleoylglycerol
CoA + N-(7-nitro-2-1,3-benzoxadiazol-4-yl)amino-palmitoyl-diacylglycerol
fluorescent-labeled substrate
-
-
?
n-octanoyl-CoA + sn-2-monooleoylglycerol
CoA + 1-octanoyl-2-oleoylglycerol
-
-
-
?
oleoyl-CoA + (Z)-1-(octadec-9-enyl)glycerol
CoA + 2-oleoyl-(Z)-1-(octadec-9-enyl)glycerol
-
-
-
?
oleoyl-CoA + (Z)-1-(octadec-9-enyl)glycerol
CoA + 3-oleoyl-(Z)-1-(octadec-9-enyl)glycerol
-
-
-
?
oleoyl-CoA + sn-1-monooleoylglycerol
CoA + sn-1,3-dioleoylglycerol
-
-
?
oleoyl-CoA + sn-3-monostearoylglycerol
CoA + 1-oleoyl-3-stearoylglycerol
-
-
?
palmitoyl-CoA + 2-hexadecylglycerol
CoA + 2-hexadecyl-1-palmitoylglycerol
-
-
-
-
?
palmitoyl-CoA + rac-1-monooleoylglycerol
CoA + ?
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intestine, at 78% the rate of sn-2-monooleoylglycerol acylation
-
-
?
palmitoyl-CoA + rac-1-monooleoylglycerol ether
CoA + ?
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intestine, at 45% the rate of sn-2-monooleoylglycerol acylation
-
-
?
palmitoyl-CoA + sn-1,2-dioleoylglycerol
CoA + 1,2-dioleoyl-3-palmitoylglycerol
-
-
-
-
?
palmitoyl-CoA + sn-1-monooleylglycerol ether
CoA + ?
-
at 5.7% of the activity with sn-2-monooleoylglycerol
-
-
?
palmitoyl-CoA + sn-2-monooleylglycerol
CoA + 2-oleyl-1-palmitoylglycerol
-
at 5.7% of the activity with sn-2-monooleoylglycerol
-
-
?
rac-1-linolenoylglycerol + oleoyl-CoA
1-linolenoyl-3-oleoylglycerol + CoA
-
-
-
?
rac-1-linoleoylglycerol + oleoyl-CoA
1-linoleoyl-3-oleoylglycerol + CoA
-
-
-
?
rac-1-monoacylglycerol + palmitoyl-CoA
diacylglycerol + CoA
-
in vitro assay in lysate of transfected CHO cells, 25°C, pH 6.4
-
-
?
stearoyl-CoA + sn-2-monooleoylglycerol
CoA + 1-stearoyl-2-oleolyglycerol
-
-
-
?
[N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)-methyl]amino]palmitoyl-CoA + 2-oleoylglycerol
CoA + 1-[N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)-methyl]amino]palmitoyl-2-oleoylglycerol
-
-
-
-
2-monooleoylglycerol + palmitoyl-CoA
2-oleoyl-3-palmitoylglycerol + CoA
-
-
-
-
?
2-monooleoylglycerol + palmitoyl-CoA
2-oleoyl-3-palmitoylglycerol + CoA
-
-
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
-
diacylglycerol biosynthetic activity
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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representative enzyme of the neutral lipid pathway
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
-
the enzyme plays a major role in the absorption of dietary fat by catalyzing the resynthesis of triacylglycerol in enterocytes
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
-
the enzyme plays a predominant role in dietary fat absorption in the small intestine, where it catalyzes the first step of triacylglycerol resynthesis in enterocytes for chylomicron formation and secretion
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
in the intestine the enzyme plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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MGAT2 may play an important role in dietary fat absorption
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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involved in synthesis of triacylglycerols
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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the enzyme is developmentally expressed, associated with physiological periods characterized by high rates of lipolysis and depends on fatty acids for energy production. During these periods the enzyme may help to retain essential fatty acids selectively
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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the enzyme may be regulated physiologically by specific intermediates of glycerolipid metabolism. In neonatal liver, signal transduction may be linked to the synthesis of complex lipids via the monoacylglycerol pathway
-
-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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the specificity of the enzyme for sn-2-monoacylglycerol and the probable enhanced affinity for sn-2-monoacylglycerols of specific acyl chains may allow selected omega6 and omega3 fatty acids to be retained within the adipocyte, while nonessential fatty acids are released for beta-oxidation in flight muscles
-
-
?
fatty acyl-CoA + sn-2-monoacylglycerol
CoA + 1,2-diacylglycerol
2-monoacylglycerol is preferred substrate
-
-
?
fatty acyl-CoA + sn-2-monoacylglycerol
CoA + 1,2-diacylglycerol
-
-
-
?
fatty acyl-CoA + sn-2-monoacylglycerol
CoA + 1,2-diacylglycerol
-
-
-
?
fatty acyl-CoA + sn-2-monoacylglycerol
CoA + 1,2-diacylglycerol
-
-
-
?
fatty acyl-CoA + sn-2-monoacylglycerol
CoA + 1,2-diacylglycerol
-
-
88% 1,2-diacylglycerol and 12% 1,3-diacylglycerol
?
linoleoyl-CoA + sn-2-monooleoylglycerol
CoA + 1-linoleoyl-2-oleoylglycerol
-
-
-
?
linoleoyl-CoA + sn-2-monooleoylglycerol
CoA + 1-linoleoyl-2-oleoylglycerol
-
-
-
-
?
monoacylglycerol + acyl-CoA
diacylglycerol + CoA
-
radioactive monoacylglycerol administration to the lumen of the small intestine
-
-
?
monoacylglycerol + fatty acyl-CoA
diacylglycerol + CoA
-
-
-
?
monoacylglycerol + fatty acyl-CoA
diacylglycerol + CoA
-
monoacylglycerol pathway predominates in enterocytes after feeding, when large amounts of 2-monoacylglycerols and fatty acids are released from the digestion of dietary lipids
-
-
?
monoacylglycerol + fatty acyl-CoA
diacylglycerol + CoA
-
monoacylglycerol pathway predominates in enterocytes after feeding, when large amounts of 2-monoacylglycerols and fatty acids are released from the digestion of dietary lipids, also active in adipose tissue
-
-
?
oleoyl-CoA + 1-oleoyl-sn-glycerol
CoA + 1,2-dioleoyl-sn-glycerol
-
-
-
-
?
oleoyl-CoA + 1-oleoyl-sn-glycerol
CoA + 1,2-dioleoyl-sn-glycerol
preferred substrate
-
-
?
oleoyl-CoA + 1-palmitoyl-sn-glycerol
CoA + 1-palmitoyl-3-oleoyl-sn-glycerol
-
-
-
-
?
oleoyl-CoA + 1-palmitoyl-sn-glycerol
CoA + 1-palmitoyl-3-oleoyl-sn-glycerol
-
-
1-palmitoyl-3-oleoyl-sn-glycerol is the predominant reaction product
?
oleoyl-CoA + sn-2-monooleoylglycerol
CoA + sn-1,2(2,3)-dioleoylglycerol
-
-
-
-
?
oleoyl-CoA + sn-2-monooleoylglycerol
CoA + sn-1,2(2,3)-dioleoylglycerol
-
-
-
?
oleoyl-CoA + sn-2-monooleoylglycerol
CoA + sn-1,2(2,3)-dioleoylglycerol
-
-
-
-
?
oleoyl-CoA + sn-2-monooleoylglycerol
CoA + sn-1,2(2,3)-dioleoylglycerol
-
-
?
oleoyl-CoA + sn-2-monooleoylglycerol
CoA + sn-1,2(2,3)-dioleoylglycerol
-
-
preferentially esterified at sn-1-position, 10% esterification at sn-3-position
?
palmitoyl-CoA + 1,2-dipalmitoylglycerol
CoA + tripalmitoylglycerol
-
i.e. 1,2-dipalmitin
-
-
?
palmitoyl-CoA + 1,2-dipalmitoylglycerol
CoA + tripalmitoylglycerol
-
i.e. 1,2-dipalmitin
-
-
?
palmitoyl-CoA + 1,3-dipalmitoylglycerol
CoA + tripalmitoylglycerol
-
i.e. 1,2-dipalmitin
-
-
?
palmitoyl-CoA + 1,3-dipalmitoylglycerol
CoA + tripalmitoylglycerol
-
i.e. 1,2-dipalmitin
-
-
?
palmitoyl-CoA + 2,3-dipalmitoylglycerol
CoA + tripalmitoylglycerol
-
i.e. 1,2-dipalmitin
-
-
?
palmitoyl-CoA + 2,3-dipalmitoylglycerol
CoA + tripalmitoylglycerol
-
i.e. 1,2-dipalmitin
-
-
?
palmitoyl-CoA + 2-palmitoyl-sn-glycerol
CoA + 1,2-dipalmitoylglycerol
-
-
-
-
?
palmitoyl-CoA + 2-palmitoyl-sn-glycerol
CoA + 1,2-dipalmitoylglycerol
-
-
-
-
?
palmitoyl-CoA + sn-1-monooleoylglycerol
CoA + ?
-
at 7.5% of the activity with sn-2-monooleoylglycerol
-
-
?
palmitoyl-CoA + sn-2-monooleoylglycerol
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
-
-
-
?
palmitoyl-CoA + sn-2-monooleoylglycerol
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
-
-
-
?
palmitoyl-CoA + sn-2-monooleoylglycerol
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
-
-
-
?
palmitoyl-CoA + sn-2-monooleoylglycerol
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
-
-
?
palmitoyl-CoA + sn-2-monooleoylglycerol
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
-
-
-
?
palmitoyl-CoA + sn-2-monooleoylglycerol
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
intestine, at 52% the rate of sn-2-monooleoylglycerol acylation
-
-
?
palmitoyl-CoA + sn-2-monooleoylglycerol
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
liver enzyme highly specific for sn-2-monooleoylglycerol
-
-
?
palmitoyl-CoA + sn-2-monooleoylglycerol
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
-
-
-
?
additional information
?
-
-
the bifunctional enzyme catalyzes the reaction of EC 2.3.1.22, acyl coenzyme A:diacylglycerol acyltransferase, and of EC 2.3.1.75, wax ester synthase, overview, linear acyl acceptor specificity, C14-C18 acceptor substrates in the wax ester synthase reaction are preferred, overview
-
-
?
additional information
?
-
-
the bifunctional enzyme catalyzes the reaction of EC 2.3.1.22, acyl coenzyme A:diacylglycerol acyltransferase, and of EC 2.3.1.75, wax ester synthase, overview, linear acyl acceptor specificity, C14-C18 acceptor substrates in the wax ester synthase reaction are preferred, overview
-
-
?
additional information
?
-
-
broad acyl-donor pattern with maximal activities for C10:0 to C16:0, the highest activity with C16:0. Preferential esterification for 2-monoacylglycerols as compared with the 1-isomers
-
-
?
additional information
?
-
-
the multifunctional enzyme plays an important role in lipid metabolism in human skin
-
-
?
additional information
?
-
-
isozyme DGAT1 also performs the reaction of the retinol O-fatty-acyltransferase, EC 2.3.1.76
-
-
?
additional information
?
-
-
the multifunctional O-acetyltransferase is catalyzing the reactions of the monoacylglycerol transferase, of the diacylglycerol transferase, EC 2.3.1.20, of the wax synthase, EC 2.3.1.75, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes the acylation of rac-1-monoacylglycerol, sn-2-monoacylglycerol, and sn-3-monoacylglycerols, the enzyme prefers monoacylglycerols containing unsaturated fatty acyls
-
-
?
additional information
?
-
-
predominant role of enzyme in dietary fat absorption
-
-
?
additional information
?
-
-
DGAT1 is catalyzing the reactions of the monoacylglycerol transferase, EC 2.3.1.22, of the diacylglycerol transferase, EC 2.3.1.20, of the wax synthase, EC 2.3.1.75, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview
-
-
?
additional information
?
-
-
no significant production of phosphatidic acid (substrate lysophosphatidic acid), triacylglycerol (diacylglycerol), or cholesterol ester (substrate cholesterol), 25°C, pH 6.4
-
-
?
additional information
?
-
-
sn-2-monoacylglycerol is preferred over sn-1(3)-monoacylglycerol
-
-
-
