2.3.1.22: 2-acylglycerol O-acyltransferase
This is an abbreviated version!
For detailed information about 2-acylglycerol O-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.22
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2.3.1.22
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n-glycans
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mgats
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diacylglycerols
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triacylglycerol
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n-acetylglucosaminyltransferase
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bisect
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glcnac
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gnt-iii
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nipecotic
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glycome
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tiagabine
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acyl-coa:diacylglycerol
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medicine
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st6gal1
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drug development
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pharmacology
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analysis
- 2.3.1.22
- n-glycans
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mgats
- diacylglycerols
- triacylglycerol
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n-acetylglucosaminyltransferase
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bisect
- glcnac
- gnt-iii
-
nipecotic
-
glycome
-
tiagabine
-
acyl-coa:diacylglycerol
- medicine
- st6gal1
- drug development
- pharmacology
- analysis
Reaction
Synonyms
acyl CoA:monoacylglycerol acyltransferase, acyl CoA:monoacylglycerol acyltransferase-2, acyl coenzyme A-monoglyceride acyltransferase, acyl coenzyme A:diacylglycerol acyltransferase, acyl-CoA:monoacylglycerol acyltransferase, acyl-CoA:monoacylglycerol transferase, acyl-coenzyme A:monoacylglycerol acyltransferase, acylglycerol palmitoyltransferase, DGAT, DGAT1/ARAT, diacylglycerol acyltransferase, GPAT4, LPGAT1, lysophosphatidylglycerol acyltransferase 1, MFAT, MGAT, MGAT1, Mgat2, MGAT3, MGOT1, MGOT2, MGOT3, MOGAT1, MOGAT2, MOGAT3, monoacylglycerol acyltransferase, monoacylglycerol acyltransferase-2, monoacylglycerol O-acyltransferase, monoacylglycerol O-acyltransferase 1, monoglyceride acyltransferase, More, multifunctional O-acyltransferase, OLE3, oleosin 3, palmitoyltransferase, acylglycerol, wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase, WS/DGAT, [acyl CoA]monoacylglycerol acyltransferase 2
ECTree
2.3.1.22 2-acylglycerol O-acyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.22 - 2-acylglycerol O-acyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
palmitoyl-CoA + sn-1,2-dioleoylglycerol
CoA + 1,2-dioleoyl-3-palmitoylglycerol
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?
2-monooleoylglycerol + palmitoyl-CoA
2-oleoyl-3-palmitoylglycerol + CoA
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?
2-monooleoylglycerol + palmitoyl-CoA
2-oleoyl-3-palmitoylglycerol + CoA
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?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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diacylglycerol biosynthetic activity
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?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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representative enzyme of the neutral lipid pathway
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-
?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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the enzyme plays a major role in the absorption of dietary fat by catalyzing the resynthesis of triacylglycerol in enterocytes
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?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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the enzyme plays a predominant role in dietary fat absorption in the small intestine, where it catalyzes the first step of triacylglycerol resynthesis in enterocytes for chylomicron formation and secretion
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?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
in the intestine the enzyme plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
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?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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MGAT2 may play an important role in dietary fat absorption
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?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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involved in synthesis of triacylglycerols
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?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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the enzyme is developmentally expressed, associated with physiological periods characterized by high rates of lipolysis and depends on fatty acids for energy production. During these periods the enzyme may help to retain essential fatty acids selectively
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?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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the enzyme may be regulated physiologically by specific intermediates of glycerolipid metabolism. In neonatal liver, signal transduction may be linked to the synthesis of complex lipids via the monoacylglycerol pathway
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?
acyl-CoA + sn-2-monoacylglycerol
CoA + diacylglycerol
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the specificity of the enzyme for sn-2-monoacylglycerol and the probable enhanced affinity for sn-2-monoacylglycerols of specific acyl chains may allow selected omega6 and omega3 fatty acids to be retained within the adipocyte, while nonessential fatty acids are released for beta-oxidation in flight muscles
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?
monoacylglycerol + fatty acyl-CoA
diacylglycerol + CoA
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?
monoacylglycerol + fatty acyl-CoA
diacylglycerol + CoA
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monoacylglycerol pathway predominates in enterocytes after feeding, when large amounts of 2-monoacylglycerols and fatty acids are released from the digestion of dietary lipids
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?
monoacylglycerol + fatty acyl-CoA
diacylglycerol + CoA
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monoacylglycerol pathway predominates in enterocytes after feeding, when large amounts of 2-monoacylglycerols and fatty acids are released from the digestion of dietary lipids, also active in adipose tissue
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?
additional information
?
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the multifunctional enzyme plays an important role in lipid metabolism in human skin
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?
additional information
?
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predominant role of enzyme in dietary fat absorption
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?
