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2.3.1.22: 2-acylglycerol O-acyltransferase

This is an abbreviated version!
For detailed information about 2-acylglycerol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.22

Reaction

acyl-CoA
+
2-acylglycerol
=
CoA
 +
diacylglycerol

Synonyms

acyl CoA:monoacylglycerol acyltransferase, acyl CoA:monoacylglycerol acyltransferase-2, acyl coenzyme A-monoglyceride acyltransferase, acyl coenzyme A:diacylglycerol acyltransferase, acyl-CoA:monoacylglycerol acyltransferase, acyl-CoA:monoacylglycerol transferase, acyl-coenzyme A:monoacylglycerol acyltransferase, acylglycerol palmitoyltransferase, DGAT, DGAT1/ARAT, diacylglycerol acyltransferase, GPAT4, LPGAT1, lysophosphatidylglycerol acyltransferase 1, MFAT, MGAT, MGAT1, Mgat2, MGAT3, MGOT1, MGOT2, MGOT3, MOGAT1, MOGAT2, MOGAT3, monoacylglycerol acyltransferase, monoacylglycerol acyltransferase-2, monoacylglycerol O-acyltransferase, monoacylglycerol O-acyltransferase 1, monoglyceride acyltransferase, More, multifunctional O-acyltransferase, OLE3, oleosin 3, palmitoyltransferase, acylglycerol, wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase, WS/DGAT, [acyl CoA]monoacylglycerol acyltransferase 2

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.22 2-acylglycerol O-acyltransferase

Expression

Expression on EC 2.3.1.22 - 2-acylglycerol O-acyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
basal and fasting-induced expression of Mogat1 is markedly diminished in the liver of mice lacking the transcription factor PPARalpha
diabetes, obesity, and lactation induce liver monoacylglycerol acyltransferase activity in rodents that is correlated with increased fat absorption
-
expression of MGAT1 is robustly induced during adipocyte differentiation and its expression is suppressed in fat of genetically-obese mice
expression of MGAT1 is robustly induced during adipocyte differentiation and its expression is suppressed in metabolically abnormal obese human subjects
hepatic expression of Mogat1 is significantly increased in the liver of fasted mice compared with mice given ad libitum access to food
hepatic LPGAT1 expression in diabetic (db/db) mice is 2fold higher than in control (db/m), consistent with 1.5fold higher hepatic monoacylglycerol acyltransferase activity
-
isozyme MGAT1 is highly induced up to 10fold by peroxisome proliferator-activated receptor gamma, PPARgamma, overexpression in human primary hepatocytes
marked weight loss following gastric bypass surgery is associated with a significant reduction in MOGAT2 and MOGAT3 expression
the infection with a short hairpin RNA-adenovirus construct lowers the lysophosphatidylglycerol acyltransferase 1 expression in diabetic (db/db) mice compared to a control virus infection in a dose-dependent manner, causing a marked reduction in serum triacylglycerol and cholesterol levels, and a significant increase in hepatic cholesterol levels
-