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2.3.1.218: phenylpropanoylacetyl-CoA synthase

This is an abbreviated version!
For detailed information about phenylpropanoylacetyl-CoA synthase, go to the full flat file.

Word Map on EC 2.3.1.218

Reaction

4-coumaroyl-CoA
+
malonyl-CoA
=
(4-coumaroyl)acetyl-CoA
+
CO2
+
CoA

Synonyms

DCS, dikeide-CoA synthase, diketide-CoA synthase, phenylpropanoyl-diketide-CoA synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.218 phenylpropanoylacetyl-CoA synthase

General Information

General Information on EC 2.3.1.218 - phenylpropanoylacetyl-CoA synthase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
the enzyme belongs to the Type III polyketide synthase family, but DCS is a unique type III PKS that releases the product as a CoA-bound form
metabolism
-
the enzyme catalyzes a step in the curcuminoid biosynthesis, pathway overview
additional information
-
DCS can collaborate with curcumin synthase, CURS, EC 2.3.1.217, which uses the reaction product feruloylacetyl-CoA for formation of curcumin, overview