2.3.1.216: 5,7-dihydroxy-2-methylchromone synthase
This is an abbreviated version!
For detailed information about 5,7-dihydroxy-2-methylchromone synthase, go to the full flat file.
Word Map on EC 2.3.1.216
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2.3.1.216
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polyketide
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arborescens
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aloe
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condensations
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octaketide
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synthases
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nonaketide
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plant-specific
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unnatural
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naphthopyrone
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inert
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chalcone
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medicago
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hexaketide
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sativa
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longest
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iterative
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lining
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molecular biology
- 2.3.1.216
- polyketide
- arborescens
-
aloe
-
condensations
-
octaketide
- synthases
-
nonaketide
-
plant-specific
-
unnatural
-
naphthopyrone
-
inert
- chalcone
-
medicago
-
hexaketide
- sativa
-
longest
-
iterative
-
lining
- molecular biology
Reaction
5 malonyl-CoA
=
5 CoA
+
Synonyms
PCS, pentaketide chromone synthase
ECTree
2.3.1.216 5,7-dihydroxy-2-methylchromone synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.3.1.216 - 5,7-dihydroxy-2-methylchromone synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5 malonyl-CoA
5 CoA + 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + H2O
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additional information
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recombinant pentaketide chromone synthasedoes not produce chalcone from 4-coumaroyl-CoA, but instead efficiently accepts malonyl-CoA as a sole substrate to carry out iterative condensations of five molecules of malonyl-CoA, producing a pentaketide, 5,7-dihydroxy-2-methylchromone. Recombinant pentaketide chromone synthaseaccepts acetyl-CoA, resulting from decarboxylation of malonyl-CoA, as a starter substrate
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