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2.3.1.212: benzalacetone synthase

This is an abbreviated version!
For detailed information about benzalacetone synthase, go to the full flat file.

Word Map on EC 2.3.1.212

Reaction

4-coumaroyl-CoA
+
malonyl-CoA
 +
H2O
= 2 CoA +
4-hydroxybenzalacetone
 + 2 CO2

Synonyms

bAS, HsPKS3, PKS1, RinPKS1, RiPKS4, RpBAS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.212 benzalacetone synthase

Reference

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Reference on EC 2.3.1.212 - benzalacetone synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zheng, D.; Hrazdina, G.
Molecular and biochemical characterization of benzalacetone synthase and chalcone synthase genes and their proteins from raspberry (Rubus idaeus L.)
Arch. Biochem. Biophys.
470
139-145
2008
Rubus idaeus (B0LDU5)
Manually annotated by BRENDA team
Morita, H.; Shimokawa, Y.; Tanio, M.; Kato, R.; Noguchi, H.; Sugio, S.; Kohno, T.; Abe, I.
A structure-based mechanism for benzalacetone synthase from Rheum palmatum
Proc. Natl. Acad. Sci. USA
107
669-673
2010
Rheum palmatum
Manually annotated by BRENDA team
Morita, H.; Tanio, M.; Kondo, S.; Kato, R.; Wanibuchi, K.; Noguchi, H.; Sugio, S.; Abe, I.; Kohno, T.
Crystallization and preliminary crystallographic analysis of a plant type III polyketide synthase that produces benzalacetone
Acta Crystallogr. Sect. F
64
304-306
2008
Rheum palmatum (Q94FV7), Rheum palmatum
Manually annotated by BRENDA team
Abe, T.; Morita, H.; Noma, H.; Kohno, T.; Noguchi, H.; Abe, I.
Structure function analysis of benzalacetone synthase from Rheum palmatum
Bioorg. Med. Chem. Lett.
17
3161-3166
2007
Rheum palmatum (Q94FV7), Rheum palmatum
Manually annotated by BRENDA team
Shimokawa, Y.; Morita, H.; Abe, I.
Structure-based engineering of benzalacetone synthase
Bioorg. Med. Chem. Lett.
20
5099-5103
2010
Rheum palmatum (Q94FV7), Rheum palmatum
Manually annotated by BRENDA team
Abe, I.; Takahashi, Y.; Morita, H.; Noguchi, H.
Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum
Eur. J. Biochem.
268
3354-3359
2001
Rheum palmatum (Q94FV7), Rheum palmatum
Manually annotated by BRENDA team
Shimokawa, Y.; Morita, H.; Abe, I.
Benzalacetone synthase
Front. Plant Sci.
3
57
2012
Rheum palmatum (Q94FV7), Rheum palmatum
Manually annotated by BRENDA team
Abe, I.; Sano, Y.; Takahashi, Y.; Noguchi, H.
Site-directed mutagenesis of benzalacetone synthase. The role of the Phe215 in plant type III polyketide synthases
J. Biol. Chem.
278
25218-25226
2003
Rheum palmatum (Q94FV7), Rheum palmatum
Manually annotated by BRENDA team
Abe, I.; Takahashi, Y.; Noguchi, H.
Enzymatic formation of an unnatural C6-C5 aromatic polyketide by plant type III polyketide synthases
Org. Lett.
4
3623-3626
2002
Rheum palmatum (Q94FV7)
Manually annotated by BRENDA team
Abe, I.; Abe, T.; Wanibuchi, K.; Noguchi, H.
Enzymatic formation of quinolone alkaloids by a plant type III polyketide synthase
Org. Lett.
8
6063-6065
2006
Rheum palmatum (Q94FV7), Rheum palmatum
Manually annotated by BRENDA team
Kumar, A.; Ellis, B.E.
A family of polyketide synthase genes expressed in ripening Rubus fruits
Phytochemistry
62
513-526
2003
Rubus idaeus
Manually annotated by BRENDA team
Borejsza-Wysocki, W.; Hrazdina, G.
Aromatic polyketide synthases (purification, characterization, and antibody development to benzalacetone synthase from raspberry fruits)
Plant Physiol.
110
791-799
1996
Rubus idaeus, Rubus idaeus Royalty
Manually annotated by BRENDA team
Lu, H.; Yang, M.; Liu, C.; Lu, P.; Cang, H.; Ma, L.
Protein preparation, crystallization and preliminary X-ray analysis of Polygonum cuspidatum bifunctional chalcone synthase/benzalacetone synthase
Acta Crystallogr. Sect. F
69
871-875
2013
Polygonum cuspidatum
Manually annotated by BRENDA team
Wang, C.; Zheng, P.; Chen, P.
Construction of synthetic pathways for raspberry ketone production in engineered Escherichia coli
Appl. Microbiol. Biotechnol.
103
3715-3725
2019
Rheum palmatum (Q94FV7)
Manually annotated by BRENDA team
Guo, H.; Yang, Y.; Ma, Y.; Liu, W.; Feng, J.; Luo, Z.; Lu, H.; Liu, C.; Yang, M.; Wang, Y.; Ma, L.
A bifunctional type III polyketide synthase from raspberry (Rubus idaeus L.) with both chalcone synthase and benzalacetone synthase activity
J. Plant Biochem. Biotechnol.
26
80-90
2017
Rubus idaeus (Q9AU11)
-
Manually annotated by BRENDA team
Lee, D.; Lloyd, N.; Pretorius, I.; Borneman, A.
Heterologous production of raspberry ketone in the wine yeast Saccharomyces cerevisiae via pathway engineering and synthetic enzyme fusion
Microb. Cell Fact.
15
49
2016
Rheum palmatum (Q94FV7)
Manually annotated by BRENDA team
Wang, J.; Wang, X.H.; Liu, X.; Li, J.; Shi, X.P.; Song, Y.L.; Zeng, K.W.; Zhang, L.; Tu, P.F.; Shi, S.P.
Synthesis of unnatural 2-substituted quinolones and 1,3-diketones by a member of type III polyketide synthases from Huperzia serrata
Org. Lett.
18
3550-3553
2016
Huperzia serrata
Manually annotated by BRENDA team
Ma, W.; Liu, C.; Yang, M.; Xue, F.; Chen, Q.; Ma, L.; Lü, H.
Preparation and crystallization of Polygonum cuspidatum benzalacetone synthase
Sheng Wu Gong Cheng Xue Bao
32
250-258
2016
Polygonum cuspidatum
Manually annotated by BRENDA team