2.3.1.208: 4-hydroxycoumarin synthase
This is an abbreviated version!
For detailed information about 4-hydroxycoumarin synthase, go to the full flat file.
Reaction
Synonyms
biphenyl synthase, BIS, BIS1, BIS2, BIS3, More
ECTree
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General Information
General Information on EC 2.3.1.208 - 4-hydroxycoumarin synthase
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evolution
physiological function
additional information
evolution
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the enzyme belongs to the type III PKS superfamily of enzymes. In a phylogenetic tree, BIS and benzophenone synthase, BPS EC 2.3.1.151, group together closely, indicating that they arise from a relatively recent functional diversification of a common ancestral gene
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BIS3 appears to catalyze the formation of phytoalexins in the transition zone, while BIS2 does not
physiological function
elicitor-treated cell cultures of Sorbus aucuparia form 4-hydroxycoumarin when fed with the N-acetylcysteamine thioester of salicylic acid (salicyl-NAC)
physiological function
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when incubated with 2-hydroxybenzoyl (salicyl)-CoA, BIS catalyzes a single decarboxylative condensation with malonyl-CoA to form 4-hydroxycoumarin, also elicitor-treated cell cultures of Sorbus aucuparia form 4-hydroxycoumarin when fed with the N-acetylcysteamine thioester of salicylic acid (salicyl-NAC). BIS is the key enzyme of biphenyl metabolism biphenyls and the related dibenzofurans are the phytoalexins of the Maloideae. Two molecules of 4-hydroxycoumarin spontaneously combine with formaldehyde to give dicoumarol, which is well-known for its blood anticoagulant activity and is the forerunner of medicinal anticoagulants
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the isozyme contains the Cys-His-Asn catalytic triad conserved in type III PKSs
additional information
the isozyme contains the Cys-His-Asn catalytic triad conserved in type III PKSs
additional information
the isozyme contains the Cys-His-Asn catalytic triad conserved in type III PKSs