2.3.1.191: UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase

This is an abbreviated version!
For detailed information about UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.191

2.3.1.191

acyltransferases

lps

francisella

trachomatis

chlamydia

lipopolysaccharide

udp-n-acetylglucosamine

homotrimer

drug development

Reaction

a (3R)-3-hydroxyacyl-[acyl-carrier protein]

a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine

a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine

Synonyms

acyl-ACP:UDP-3-O-(3-hydroxyacyl)-GlcN N-acyltransferase, acyltransferase LpxD, CtLpxD, EcLpxD, firA, La0512, LpxD, LpxD1, Lpxd2, PA3646, UDP-3-O-(R-3-hydroxyacyl)-glucosamine acyltransferase, UDP-3-O-acyl-glucosamine N-acyltransferase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.191 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase

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Results	in table
1	Activating Compound
23563	AA Sequence
1	Application
14	Cloned(Commentary)
6	Crystallization (Commentary)
22	General Information
2	IC50 Value
11	Inhibitors
11	kcat/KM [mM/s]
7	Ki Value [mM]
25	KM Value [mM]
2	Localization
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
33	Organism
11	Pathway
45	PDB ID
2	pH Optimum
16	Protein Variants
7	Purification (Commentary)
1	Reaction
29	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
21	Substrates and Products (Substrate)
4	Subunits
32	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
24	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.3.1.191 - UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase

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(3R)-3-hydroxylauroyl-methylphosphopantetheine

Escherichia coli

competitive inhibitor with respect to UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine and an uncompetitive inhibitor with respect to (3R)-3-hydroxymyristoyl-[acyl-carrier protein]

696264

(3R)-3-hydroxylauroylmethylphosphopantetheine

Escherichia coli

uncompetitive inhibitor against (3R)-3-hydroxymyristoyl-[acyl-carrier protein] and a competitive inhibitor against UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine

696264

(3R)-3-hydroxymyristoyl-[acyl-carrier protein]

Escherichia coli

696264

4-(2-chlorophenyl)-3-hydroxy-7,7-dimethyl-2-phenyl-7,8-dihydro-2H-pyrazolo[3,4-b]quinolin-5(6H)-one

acyl-carrier protein

competitive inhibitor with respect to (3R)-3-hydroxymyristoyl-[acyl-carrier protein] and a noncompetitive inhibitor with respect to UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine

696264

Ca2+

Escherichia coli

inhibition is overcome by the addition of excess (3R)-3-hydroxymyristoyl-[acyl-carrier protein]

Mg2+

RJPXD33

i.e. TNLYMLPKWDIP, peptide inhibitor, binds to both UDP-N-acetylglucosamine acyltransferase (LpxA, EC 2.3.1.129) and UDP-3-O-(acyl)-glucosamine acyltransferase. Comparison with binding to LpxA suggests overlap with the acyl-phosphopantetheine arm of acyl-ACP, thereby inhibiting acyl-ACP from binding to LpxD. RJPXD33 binds to LpxD without the prior binding of other ligands

TNLYMLPKWDIP-NH2

i.e. peptide RJPXD33

UDP-2-N-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine

Escherichia coli

noncompetitive inhibitor against both substrates

696264

additional information

Escherichia coli

divalent cations inhibit (3R)-3-hydroxymyristoyl-[acyl-carrier protein]-dependent acylation but not (3R)-3-hydroxylauroylmethylphosphopantetheine-dependent acylation, indicating that the acidic recognition helix of (3R)-3-hydroxymyristoyl-[acyl-carrier protein] contributes to binding; Na+ and K+ ions do not inhibit LpxD activity

696264