2.3.1.184: acyl-homoserine-lactone synthase

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For detailed information about acyl-homoserine-lactone synthase, go to the full flat file.

Reaction

Synonyms

3-oxo-C12-HSL synthase, AbaI, ACII, acyl homoserine lactone synthase, acyl-homoserine lactone synthase, acyl-homoserine-lactone synthase, acyl-homoserinelactone synthase, acyl-HSL synthase, acylhomoserine lactone synthase, AHL synthase, AHS, AHSL synthase, AhyI, AinS, AinS protein, AurI, autoinducer synthase, autoinducer synthesis protein rhlI, C4-HSL synthase, C6-AHL synthase, CsaI, EsaI, ExpI, expIEcz, ExpISCC1, ExpISCC3065, hdtS, HHL synthase, LasI, LasI synthase, LasI/R, LasR, LuxI, LuxI protein, LuxM, More, MrlI1, MrlI2, MrtI, mtqI, N-acyl homoserine lactone synthase, N-acyl-homoserine lactone synthase, N-hexanoyl homoserine lactone synthase, NmuI, Nmul_A2390, PgaI, PhzI, PppuI, PsyI, RhlI, RhlI/R, signal synthase CviI, SmaI, SpnI, TofI, TraI, YenI, YpeRI, YspI, YspRI

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.184 acyl-homoserine-lactone synthase

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Results	in table
4	Activating Compound
6328	AA Sequence
5	Application
1	CAS Registry Number
27	Cloned(Commentary)
4	Crystallization (Commentary)
10	Expression
66	General Information
26	Inhibitors
19	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
85	Natural Substrates/ Products (Substrates)
84	Organism
3	Pathway
1	PDB ID
4	pH Optimum
3	pH Range
1	pI Value
49	Protein Variants
7	Purification (Commentary)
9	Reaction
72	Reference
3	Specific Activity [micromol/min/mg]
137	Substrates and Products (Substrate)
5	Subunits
158	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.184 - acyl-homoserine-lactone synthase

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SYSTEMATIC NAME

IUBMB Comments

acyl-[acyl-carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)

Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates [1]. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA [1]. S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone [1].