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2.3.1.184: acyl-homoserine-lactone synthase

This is an abbreviated version!
For detailed information about acyl-homoserine-lactone synthase, go to the full flat file.

Word Map on EC 2.3.1.184

Reaction

an acyl-[acyl-carrier protein]
+
S-adenosyl-L-methionine
=
an [acyl-carrier protein]
 +
S-methyl-5'-thioadenosine
 +
an N-acyl-L-homoserine lactone

Synonyms

3-oxo-C12-HSL synthase, AbaI, ACII, acyl homoserine lactone synthase, acyl-homoserine lactone synthase, acyl-homoserine-lactone synthase, acyl-homoserinelactone synthase, acyl-HSL synthase, acylhomoserine lactone synthase, AHL synthase, AHS, AHSL synthase, AhyI, AinS, AinS protein, AurI, autoinducer synthase, autoinducer synthesis protein rhlI, C4-HSL synthase, C6-AHL synthase, CsaI, EsaI, ExpI, expIEcz, ExpISCC1, ExpISCC3065, hdtS, HHL synthase, LasI, LasI synthase, LasI/R, LasR, LuxI, LuxI protein, LuxM, More, MrlI1, MrlI2, MrtI, mtqI, N-acyl homoserine lactone synthase, N-acyl-homoserine lactone synthase, N-hexanoyl homoserine lactone synthase, NmuI, Nmul_A2390, PgaI, PhzI, PppuI, PsyI, RhlI, RhlI/R, signal synthase CviI, SmaI, SpnI, TofI, TraI, YenI, YpeRI, YspI, YspRI

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.184 acyl-homoserine-lactone synthase

Expression

Expression on EC 2.3.1.184 - acyl-homoserine-lactone synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
ExpR negatively regulates ExpI expression
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ExpR1 negatively regulates ExpI expression
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expression of acyl-homoserine lactone synthase gene mtqI from Mesorhizobium tianshanense requires acyl-homoserine lactones and the LuxR-type transcriptional activator MtqR
expression of isoform LasI increases with increase in biofilm growth
expression of isoform RhlI decreases during log phase of biofilm growth
RsaLWCS displays a strong repressive effect on the promoter of the quorum sensing signal synthase gene, ppuI. Purified RsaLWCS specifically binds to ppuI on a DNA region overlapping the predicted sigma70-binding site, but the RsaLWCS protein is not able to form stable complexes efficiently with a probe encompassing the ppuI promoter, the RsaLWCS/PppuI complex is not stable in vitro, RsaLWCS needs a molecular interactor/cofactor specific for Pseudomonas putida WCS358 to repress ppuI transcription. RsaLWCS regulates siderophore-mediated growth limitation of plant pathogens and biofilmcformation, two processes relevant for plant growth-promoting activity. Mutational analysis using a chimeric RsaLWCS mutant, RsaLWCS molecular mechanism, overview
RsaLWCS does not show a repressive effect on the promoter of the QS signal synthase gene lasI in Pseudomonas aeruginosa. RsaLWCS formed stable complexes with the promoter of lasI, the gene orthologous to ppuI. RsaLWCS regulates siderophore-mediated growth limitation of plant pathogens and biofilm formation, two processes relevant for plant growth-promoting activity. RsaL binds close to LasR on the same bidirectional promoter, repressing the transcription of both the lasI and rsaL genes. Molecular mechanism, overview
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