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2.3.1.181: lipoyl(octanoyl) transferase

This is an abbreviated version!
For detailed information about lipoyl(octanoyl) transferase, go to the full flat file.

Word Map on EC 2.3.1.181

Reaction

octanoyl-[acyl-carrier protein]
+
protein
=
protein 6-N-(octanoyl)lysine
+
Acyl carrier protein

Synonyms

ACP: GcvH octanoyltransferase, ACP:protein-N-octanoyltransferase, At1g47578, At4G31050, AtLIP2p2, bLT, LIP2, LIP2P1, Lip2p2, LIP3, LipB, LipB octanoyltransferase, LipM, lipoate/octanoate transferase, lipoyl (octanoyl)-acyl carrier protein:protein transferase, lipoyl(octanoyl) transferase, lipoyl(octanoyl) transferase 2, lipoyl(octanoyl)-[acyl-carrier-protein]-protein N-lipoyltransferase, lipoyl(octanoyl)transferase, lipoyltransferase, LIPT2, octanoyl (lipoyl): N-octanoyl (lipoyl) transferase, octanoyl-acyl carrier protein:protein-N-octanoyltransferase, octanoyl-[acyl carrier protein {ACP}]:protein N-octanoyltransferase, octanoyl-[acyl carrier protein]-protein N-octanoyltransferase, octanoyl-[acyl carrier protein]:protein N-octanoyltransferase, octanoyltransferase LipM, plastidial octanoyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.181 lipoyl(octanoyl) transferase

Systematic Name

Systematic Name on EC 2.3.1.181 - lipoyl(octanoyl) transferase

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SYSTEMATIC NAME
IUBMB Comments
octanoyl-[acyl-carrier protein]:protein N-octanoyltransferase
This is the first committed step in the biosynthesis of lipoyl cofactor. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [2,3]. Lipoyl-ACP can also act as a substrate [4] although octanoyl-ACP is likely to be the true substrate [6]. The other enzyme involved in the biosynthesis of lipoyl cofactor is EC 2.8.1.8, lipoyl synthase. An alternative lipoylation pathway involves EC 6.3.1.20, lipoate---protein ligase, which can lipoylate apoproteins using exogenous lipoic acid (or its analogues).