2.3.1.181: lipoyl(octanoyl) transferase
This is an abbreviated version!
For detailed information about lipoyl(octanoyl) transferase, go to the full flat file.
Word Map on EC 2.3.1.181
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2.3.1.181
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lipoylation
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lipoic
-
octanoylated
-
lipoyl-amp
-
2-oxoacid
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h-protein
-
lipoate-dependent
-
lipoate-protein
-
acidosis
-
octanoic
-
2-ketoacid
-
2-oxoadipate
-
epsilon-amino
-
fe-s
-
alpha-keto
-
swinging
-
fujiwara
-
nonketotic
-
medicine
- 2.3.1.181
-
lipoylation
-
lipoic
-
octanoylated
- lipoyl-amp
- 2-oxoacid
- h-protein
-
lipoate-dependent
-
lipoate-protein
- acidosis
-
octanoic
-
2-ketoacid
- 2-oxoadipate
-
epsilon-amino
- fe-s
-
alpha-keto
-
swinging
-
fujiwara
-
nonketotic
- medicine
Reaction
Synonyms
ACP: GcvH octanoyltransferase, ACP:protein-N-octanoyltransferase, At1g47578, At4G31050, AtLIP2p2, bLT, LIP2, LIP2P1, Lip2p2, LIP3, LipB, LipB octanoyltransferase, LipM, lipoate/octanoate transferase, lipoyl (octanoyl)-acyl carrier protein:protein transferase, lipoyl(octanoyl) transferase, lipoyl(octanoyl) transferase 2, lipoyl(octanoyl)-[acyl-carrier-protein]-protein N-lipoyltransferase, lipoyl(octanoyl)transferase, lipoyltransferase, LIPT2, octanoyl (lipoyl): N-octanoyl (lipoyl) transferase, octanoyl-acyl carrier protein:protein-N-octanoyltransferase, octanoyl-[acyl carrier protein {ACP}]:protein N-octanoyltransferase, octanoyl-[acyl carrier protein]-protein N-octanoyltransferase, octanoyl-[acyl carrier protein]:protein N-octanoyltransferase, octanoyltransferase LipM, plastidial octanoyltransferase
ECTree
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Reference on EC 2.3.1.181 - lipoyl(octanoyl) transferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhao, X.; Miller, J.R.; Cronan, J.E.
The reaction of LipB, the octanoyl-[acyl carrier protein]:protein N-octanoyltransferase of lipoic acid synthesis, proceeds through an acyl-enzyme intermediate
Biochemistry
44
16737-16746
2005
Escherichia coli
vanden Boom, T.J.; Reed, K.E.; Cronan, J.E.
Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system
J. Bacteriol.
173
6411-6420
1991
Escherichia coli
Jordan, S.W.; Cronan, J.E., Jr.
The Escherichia coli lipB gene encodes lipoyl (octanoyl)-acyl carrier protein:protein transferase
J. Bacteriol.
185
1582-1589
2003
Escherichia coli
Jordan, S.W.; Cronan, J.E.
A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate dehydrogenase complex in Escherichia coli
J. Biol. Chem.
272
17903-17906
1997
Escherichia coli, Neurospora crassa, Pisum sativum
Wada, M.; Yasuno, R.; Jordan, S.W.; Cronan, J.E., Jr.; Wada, H.
Lipoic acid metabolism in Arabidopsis thaliana: cloning and characterization of a cDNA encoding lipoyltransferase
Plant Cell Physiol.
42
650-656
2001
Arabidopsis thaliana
Nesbitt, N.M.; Baleanu-Gogonea, C.; Cicchillo, R.M.; Goodson, K.; Iwig, D.F.; Broadwater, J.A.; Haas, J.A.; Fox, B.G.; Booker, S.J.
Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase
Protein Expr. Purif.
39
269-282
2005
Escherichia coli
Ma, Q.; Zhao, X.; Nasser Eddine, A.; Geerlof, A.; Li, X.; Cronan, J.E.; Kaufmann, S.H.; Wilmanns, M.
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase
Proc. Natl. Acad. Sci. USA
103
8662-8667
2006
Mycobacterium tuberculosis (P9WK83), Mycobacterium tuberculosis H37Rv (P9WK83)
Fujiwara, K.; Hosaka, H.; Matsuda, M.; Okamura-Ikeda, K.; Motokawa, Y.; Suzuki, M.; Nakagawa, A.; Taniguchi, H.
Crystal structure of bovine lipoyltransferase in complex with lipoyl-AMP
J. Mol. Biol.
371
222-234
2007
Bos taurus (O46419), Bos taurus
Hermes, F.A.; Cronan, J.E.
Scavenging of cytosolic octanoic acid by mutant LplA lipoate ligases allows growth of Escherichia coli strains lacking the LipB octanoyltransferase of lipoic acid synthesis
J. Bacteriol.
191
6796-6803
2009
Escherichia coli
Guenther, S.; Matuschewski, K.; Mueller, S.
Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival
PLoS ONE
4
e5510
2009
Plasmodium falciparum
Christensen, Q.H.; Cronan, J.E.
Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases
Biochemistry
49
10024-10036
2010
Bacillus subtilis
Hassan, B.H.; Cronan, J.E.
Protein-protein interactions in assembly of lipoic acid on the 2-oxoacid dehydrogenases of aerobic metabolism
J. Biol. Chem.
286
8263-8276
2011
Escherichia coli
Martin, N.; Christensen, Q.H.; Mansilla, M.C.; Cronan, J.E.; de Mendoza, D.
A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis
Mol. Microbiol.
80
335-349
2011
Bacillus subtilis
Christensen, Q.H.; Martin, N.; Mansilla, M.C.; de Mendoza, D.; Cronan, J.E.
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis
Mol. Microbiol.
80
350-363
2011
Bacillus subtilis
Ewald, R.; Hoffmann, C.; Neuhaus, E.; Bauwe, H.
Two redundant octanoyltransferases and one obligatory lipoyl synthase provide protein-lipoylation autonomy to plastids of Arabidopsis
Plant Biol.
16
35-42
2014
Arabidopsis thaliana (P0C7R2), Arabidopsis thaliana (Q9SXP7)
Ewald, R.; Hoffmann, C.; Florian, A.; Neuhaus, E.; Fernie, A.R.; Bauwe, H.
Lipoate-protein ligase and octanoyltransferase are essential for protein lipoylation in mitochondria of Arabidopsis
Plant Physiol.
165
978-990
2014
Arabidopsis thaliana (Q9SXP7)
Hermes, F.A.; Cronan, J.E.
The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis
Yeast
30
415-427
2013
Saccharomyces cerevisiae
Habarou, F.; Hamel, Y.; Haack, T.; Feichtinger, R.; Lebigot, E.; Marquardt, I.; Busiah, K.; Laroche, C.; Madrange, M.; Grisel, C.; Pontoizeau, C.; Eisermann, M.; Boutron, A.; Chrétien, D.; Chadefaux-Vekemans, B.; Barouki, R.; Bole-Feysot, C.; Nitschke, P
Biallelic mutations in LIPT2 cause a mitochondrial lipoylation defect associated with severe neonatal encephalopathy
Am. J. Hum. Genet.
101
283-290
2017
Homo sapiens (A6NK58)
Martins-Noguerol, R.; Moreno-Perez, A.J.; Acket, S.; Makni, S.; Garces, R.; Troncoso-Ponce, A.; Salas, J.J.; Thomasset, B.; Martinez-Force, E.
Lipidomic analysis of plastidial octanoyltransferase mutants of Arabidopsis thaliana
Metabolites
9
209
2019
Arabidopsis thaliana (P0C7R2), Arabidopsis thaliana (Q948J9), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (P0C7R2), Arabidopsis thaliana Col-0 (Q948J9)
Bernardinelli, E.; Costa, R.; Scantamburlo, G.; To, J.; Morabito, R.; Nofziger, C.; Doerrier, C.; Krumschnabel, G.; Paulmichl, M.; Dossena, S.
Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death
PLoS ONE
12
e0179591
2017
Homo sapiens (A6NK58), Homo sapiens
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