2.3.1.180: beta-ketoacyl-[acyl-carrier-protein] synthase III
This is an abbreviated version!
For detailed information about beta-ketoacyl-[acyl-carrier-protein] synthase III, go to the full flat file.
Word Map on EC 2.3.1.180
-
2.3.1.180
-
malonyl-acp
-
thiolactomycin
-
transacylase
-
mycolic
-
drug development
-
acyl-acps
-
claisen
-
glaucescens
-
isobutyryl-coa
-
transacylation
-
cuphea
-
pharmacology
-
malonyl-coa:acp
-
bcfas
-
synthesis
-
biofuel production
-
medicine
- 2.3.1.180
- malonyl-acp
- thiolactomycin
-
transacylase
-
mycolic
- drug development
- acyl-acps
-
claisen
- glaucescens
- isobutyryl-coa
-
transacylation
- cuphea
- pharmacology
-
malonyl-coa:acp
-
bcfas
- synthesis
- biofuel production
- medicine
Reaction
Synonyms
3-ketoacyl ACP synthase III, 3-ketoacyl acyl carrier protein synthase III, 3-ketoacyl carrier protein synthase III, 3-ketoacyl-(acyl carrier protein) synthase IIIA, 3-ketoacyl-(acyl carrier protein) synthase IIIB, 3-ketoacyl-ACP synthase III, 3-ketoacyl-acyl carrier protein synthase III, 3-ketoacyl-acyl-carrier protein synthase III, 3-oxoacyl-ACP synthase III, 3-oxoacyl-acyl carrier protein synthase III, 3-oxoacyl-[acyl-carrier-protein] synthase III, 3-oxoacyl:ACP synthase III, AbyA1, acetoacetyl-ACP synthase, acetyl-CoA:ACP transacylase, acetyl-CoA:malonyl-[acyl-carrier-protein] C-acyltransferase, ACO synthase III, ACP synthase III, AknE2, AlnI, AsuC3, AsuC4, AviN, BenQ, beta-ketoacyl (acyl carrier protein) synthase III, beta-ketoacyl acyl carrier protein synthase III, beta-ketoacyl acyl-carrier protein synthase III, beta-ketoacyl-(ACP) synthase III, beta-ketoacyl-(acyl-carrier-protein) synthase III, beta-ketoacyl-ACP III, beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP synthase III, beta-ketoacyl-ACP synthase III-like protein, beta-ketoacyl-ACP-synthase III, beta-ketoacyl-acyl carrier protein (ACP) synthase III, beta-ketoacyl-acyl carrier protein synthase III, beta-ketoacyl-acyl carrier protein synthase-III, beta-ketoacyl-[acyl-carrier protein (ACP)] synthase III, beta-ketoacyl-[acyl-carrier-protein] synthase III, beta-ketoacyl:acyl carrier protein synthase III, beta-ketoacylacylcarrier protein synthase III, beta-ketobutyryl-ACP synthase, BomK, CalO4, CerJ, ChlB3, ChlB6, CorB, DarB, DpsC, ecFabH, ecKAS III, efFabH, EsmD1, EvrI, FabH, FabH1, FabH2, FabH3, FabHA, FabHB, fatty acid biosynthesis, enzyme H, fatty acid synthase type II condensing enzyme, FdmS, FrenI/FrnI, HedS, hiFabH, initiation ketosynthase, JcKAS III, KAS III, KAS III-like protein, KAS IIIA, KAS IIIB, KAS-III, KAS3a, KAS3b, KASIII, KijB, LstA, LstAB, LstB, mtFabH, MxnB, nmFabH, NphT7, NzsF, paFabH, PpyS, PqsBC, PqsD, PtmR, RedP, RevR, RkD, saFabH, SalQ/Orf12, short-chain condensing enzyme, spFabH, spyFabH, SsfN, TcsB, ThgI, TiaF, Tmn15, [acyl-carrier-protein] synthase III
ECTree
2.3.1.180 beta-ketoacyl-[acyl-carrier-protein] synthase IIIAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.180 - beta-ketoacyl-[acyl-carrier-protein] synthase III
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E)-oct-2-enethioyl-CoA + (3S,5Z,8Z)-3-hydroxytetradeca-5,8-dienoyl-CoA
(3S,5S,7Z,10Z)-2-hexyl-3,5-dihydroxyhexadeca-7,10-dienoic acid + ?
-
-
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
2-methylbutyryl-CoA is the preferred primer substrate of isozyme FabH1
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
2-methylcrotonyl-CoA + malonyl-[acyl-carrier protein]
(4E)-4-methylhex-4-enoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
acetyl-CoA + ACP
acetyl-ACP + CoA
acetyl-CoA:ACP transacylase activity
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
acetyl-CoA + [acyl-carrier protein]
acetyl-[acyl-carrier protein] + CoA
the enzyme also shows acetyltransferase activity
-
-
?
arachidoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-docosanoyl-[acyl-carrier protein] + CoA + CO2
-
low activity
-
-
?
butanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) (2E)-2,4-dimethylpent-2-enethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl (3E)-3,5-dimethylhex-3-enoate + N-(2-sulfanylethyl)acetamide
-
44% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 2-hydroxy-6-methylbenzene-1-carbothioate
7-deoxy-7-demethylpactamycin + N-(2-sulfanylethyl)acetamide
-
100% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 2-methylbutanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 2-methylbutanoate + N-(2-sulfanylethyl)acetamide
-
20% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 2-methylpropanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 2-methylpropanoate + N-(2-sulfanylethyl)acetamide
-
83% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 3-aminobenzene-1-carbothioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 3-aminobenzoate + N-(2-sulfanylethyl)acetamide
-
17% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 3-methylbutanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 3-methylbutanoate + N-(2-sulfanylethyl)acetamide
-
61% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 4-chlorobutanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 4-chlorobutanoate + N-(2-sulfanylethyl)acetamide
-
100% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) benzenecarbothioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl benzoate + N-(2-sulfanylethyl)acetamide
-
43% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) butanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl butanoate + N-(2-sulfanylethyl)acetamide
-
91% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) cycloheptanecarbothioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl cycloheptanecarboxylate + N-(2-sulfanylethyl)acetamide
-
87% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) cyclohexanecarbothioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl cyclohexanecarboxylate + N-(2-sulfanylethyl)acetamide
-
57% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) ethanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl acetate + N-(2-sulfanylethyl)acetamide
-
71% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) phenylethanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl phenylacetate + N-(2-sulfanylethyl)acetamide
-
95% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) propanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl propanoate + N-(2-sulfanylethyl)acetamide
-
87% conversion
-
-
?
de-6-methylsalicylyl-7-deoxypactamycin + 6-methylsalicylyl N-acetylcysteamine thioester
?
-
-
-
-
?
de-6-methylsalicylyl-pactamycate + 6-methylsalicylyl N-acetylcysteamine thioester
?
-
-
-
-
?
decanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-lauroyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
heptanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylpentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
malonyl-ACP + acyl-CoA
3-oxoacyl-ACP + CoA + CO2
specificity for branched acyl-CoA substrate
-
-
?
myristoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
octanoyl-CoA + (3S,5Z,8Z)-3-hydroxytetradeca-5,8-dienoyl-CoA
(5S,7Z,10Z)-2-hexyl-5-hydroxy-3-oxohexadeca-7,10-dienoic acid + ?
-
-
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
palmitoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-stearoyl-[acyl-carrier protein] + CoA + CO2
propanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxopentanoyl-[acyl-carrier-protein] + CoA + CO2
-
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
stearoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-arachidoyl-[acyl-carrier protein] + CoA + CO2
-
low activity
-
-
?
valeryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-heptanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
valeryl-CoA + malonyl-[acyl-carrier protein]
3-oxoheptanoyl-[acyl-carrier-protein] + CoA + CO2
-
-
-
?
[PtmQ]-S-methyl 2-methylbenzene-1-carbothioate + de-6-methylsalicylyl-pactamycin
pactamycin + ?
-
-
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
2-methylbutyryl-CoA is the preferred substrate
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
2-methylbutyryl-CoA is the preferred substrate
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme shows a high selectivity for acetyl-CoA over acyl-ACP as its substrate. Escherichia coli FabH is inactive for longer-chain (greater than C4) primers and all branched-chain CoA primers
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Myxococcus fulvus Mxf50
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Polymorphospora rubra K07-0510
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Pseudomonas putida BW11M1
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Streptomyces albus XM211
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Streptomyces antibioticus DSM 4072
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Streptomyces antibioticus Tue2706
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Streptomyces galilaeus 3AR-33
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Streptomyces griseus ATCC 49344
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Streptomyces roseofulvus AM-3867
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Streptomyces sp. MA347
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Streptomyces tendae HKI 017
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-ACP
acetoacetyl-ACP + CoA + CO2
ACP acceptor substrates with eight carbons and potentially also with ten carbons are used, substrate specificity is not limited to using C2-CoA
-
-
?
acetyl-CoA + malonyl-ACP
acetoacetyl-ACP + CoA + CO2
ACP acceptor substrates with eight carbons and potentially also with ten carbons are used, substrate specificity is not limited to using C2-CoA
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
first condensing step in fatty acid synthase reaction, the enzyme is feedback regulated in biosynthesis of medium chain fatty acids
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
regulation of the enzyme activity is involved in regulation of fatty acid synthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
regulation of the enzyme activity is involved in regulation of the fatty acid synthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
initial condensation reaction to start fatty acid biosynthesis by the type II fatty acid synthase, the enzyme is a target for fatty acid synthesis regulation by acyl-[acyl-carrier-protein]
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
regulation by feedback inhibition
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme catalyzes the initial step in fatty acid biosynthesis via type II fatty acid synthase
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
acetyl-CoA and propionyl-CoA are the preferred primers
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme is essential for fatty acid biosynthesis, especially of short-chain fatty acids, by fatty acid synthase II initiating the elongation of fatty acids
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme is essential for fatty acid biosynthesis, especially of short-chain fatty acids, by fatty acid synthase II initiating the elongation of fatty acids
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
condensation of fatty acid synthase I-derived acyl-CoAs with malonyl-ACPs to initiates fatty acid synthase II-catalyzed fatty acid elongation, the enzyme links the two fatty acid synthase complexes
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
condensation of fatty acid synthase I-derived acyl-CoAs with malonyl-ACPs to initiates fatty acid synthase II-catalyzed fatty acid elongation, the enzyme links the two fatty acid synthase complexes
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
low activity
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme catalyzes the initial step in fatty acid biosynthesis via type II fatty acid synthase
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme is involved in initiation of fatty acid elogantion by the fatty acid synthase II catalyzing the decarboxylative condensation between malonyl-ACP and acetyl-CoA, the enzyme is essential for viability, overview
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
preferred CoA primer is acetyl-CoA
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
FabH initiates the elongation of straight-chain fatty acids by the fatty acid synthase II complex, fatty acid synthesis pathway overview
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme initiates the fatty acid biosynthesis, overview
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
substrate malonyl-ACP is produced by FabC or Escherichia coli AcpP, but not by TcmM
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
-
the condensation reaction is the first step in elongation in fatty acid synthesis by fatty acid synthase complex
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
the enzyme prefers long-chain fatty acids
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
the enzyme prefers long-chain fatty acids
-
-
?
butanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2
-
-
-
?
butanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
heptanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
heptanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
heptanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
-
high activity
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
isobutyryl-CoA is the preferred CoA primer substrate
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
isobutyryl-CoA is the preferred primer substrate
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
isovaleryl-CoA is the preferred primer substrate of isozyme FabH2
-
-
?
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
-
lauroyl-CoA is the preferred primer
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
the primer substrate lauroyl-CoA is bound to subunit A, binding structure, lauroyl is bound in a channel
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
the primer substrate lauroyl-CoA is bound to subunit A, binding structure, lauroyl is bound in a channel
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
malonyl-ACP + acetyl-CoA
CO2 + CoA + acetoacetyl-ACP
-
-
-
-
?
malonyl-ACP + acetyl-CoA
CO2 + CoA + acetoacetyl-ACP
-
-
-
?
myristoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
myristoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme plays a key role in initiation of the long-chain fatty acid route of meromycolic acid biosynthesis, a different enzyme with specificity for short-chain acyl-CoAs might also be responsible for meromycolic acid biosynthesis, biosynthetic pathway regulation mechanism
-
-
?
myristoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme prefers long-chain acyl-CoA substrates for the Claisen condensation reaction
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2
-
low activity with octanoyl-CoA as primer substrate of isozyme FabH1, no activity with FabH2
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
palmitoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-stearoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
palmitoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-stearoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
acetyl-CoA and propionyl-CoA are the preferred primers
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
the enzyme specifies the propionate-starter unit for type II polyketide biosynthesis
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
intermediate binding of propionyl to the enzyme at Ser118
-
-
?
additional information
?
-
-
substrate specificities of FabH1 and FabH2 with different primer substrates, both isozymes prefer branched-chain fatty acids
-
-
?
additional information
?
-
-
fatty acid composition and acyl-ACP content in the seeds
-
-
?
additional information
?
-
-
structural and dynamical aspect of catalytic mechanism of FabH, overview
-
-
?
additional information
?
-
-
the enzyme is a key catalyst of fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is important in fatty acid biosynthesis
-
-
?
additional information
?
-
the enzyme is important in fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is important in fatty acid biosynthesis
-
-
?
additional information
?
-
-
the wild-type enzyme is able to induce synthesis of polyhydroxyalkanoates PHA copolymers from glucose in a strain which is transformed with gene phaC from Aeromonas caviae or gene phaC1 from Pseudomonas sp. strain 61-3, thus fatty acid biosynthesis may supply monomers for PHA production, overview
-
-
?
additional information
?
-
-
no activity with hexanoyl-CoA or octanoyl-CoA
-
-
?
additional information
?
-
-
the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
-
-
?
additional information
?
-
-
the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
-
-
?
additional information
?
-
substrate binding channel at the active site, structure, overview
-
-
?
additional information
?
-
-
substrate binding channel at the active site, structure, overview
-
-
?
additional information
?
-
FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence
-
-
?
additional information
?
-
-
FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence
-
-
?
additional information
?
-
the enzyme is essential for fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is essential for fatty acid biosynthesis
-
-
?
additional information
?
-
Lactiplantibacillus plantarum ATCC BAA-793
the enzyme is essential for fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme prefers short-chain CoA primer substrates
-
-
?
additional information
?
-
-
the enzyme prefers short-chain CoA primer substrates
-
-
?
additional information
?
-
beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria
-
-
?
additional information
?
-
-
beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria
-
-
?
additional information
?
-
substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview
-
-
?
additional information
?
-
-
substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview
-
-
?
additional information
?
-
beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria
-
-
?
additional information
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substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview
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additional information
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specificity of the enzyme for longer acyl-CoA chains, overview, the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
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additional information
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specificity of the enzyme for longer acyl-CoA chains, overview, the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
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additional information
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substrate specificity, no activity with isovaleryl-CoA, butyryl-CoA, and acetyl-CoA, the enzyme prefers long chain acyl-CoAs as primers rather than acyl-ACPs
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additional information
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FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview
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additional information
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FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview
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additional information
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specificity of the enzyme for longer acyl-CoA chains, overview, the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
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?
additional information
?
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FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview
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additional information
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fatty acid composition and acyl-ACP content in the leaves
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additional information
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the enzyme shows also acetyl-CoA-[acyl-carrier-protein] transacylase activity
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additional information
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the enzyme shows also acetyl-CoA-[acyl-carrier-protein] transacylase activity
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additional information
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substrate binding channel at the active site, structure, overview
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additional information
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substrate binding channel at the active site, structure, overview
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additional information
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fatty acid composition and acyl-ACP content in the leaves
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additional information
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fatty acid composition and acyl-ACP content in the leaves
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additional information
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substrate specificity, the enzyme also shows acetyltransferase activity, which is lower than the 3-ketoacyl carrier protein synthase activity
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additional information
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the enzyme possesses a large primer binding pocket determining the substrate specificity
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additional information
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substrate specificity, the recombinant enzyme prefers straight short-chain CoA primer substrates, preferred CoA primer is acetyl-CoA, no activity with lauroyl-CoA and palmitoyl-CoA
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additional information
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substrate specificity, the recombinant enzyme prefers straight short-chain CoA primer substrates, preferred CoA primer is acetyl-CoA, no activity with lauroyl-CoA and palmitoyl-CoA
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additional information
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fatty acid composition of wild-type and mutant strains, the latter expressing plasmid-encoded Escherichia coli or Streptomyces glaucescens enzymes, overview
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additional information
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the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
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additional information
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the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
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additional information
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the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
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?
additional information
?
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the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
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?
additional information
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the enzyme is involved in biosynthesis of straight-chain and branched-chain fatty acids with the specificity for acyl-CoA substrate determining the produced fatty acid spectrum
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additional information
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the enzyme is not directly involved in tetracenomycin C biosynthesis
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additional information
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the enzyme shows also acyl-CoA:[acyl-carrier-protein] transacylase activity, i.e. ACAT activity, in a ratio of 1:0.12 with beta-oxoacyl-[acyl-carrier-protein] synthase III activity
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additional information
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no activity with acetyl-CoA, malonyl-CoA, and 2-methylmalonyl-CoA as primer for elongation of fatty acids, the enzyme shows also acyl-CoA:ACP transacylase activity for transfer of propionate to ACP
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additional information
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Product profile analysis of FabH from Synechococcus sp. strain PCC 7002, overview. t´The major products are lauric acid, myristic acid, palmitic acid, and stearic acid
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additional information
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Product profile analysis of FabH from Synechococcus sp. strain PCC 7002, overview. t´The major products are lauric acid, myristic acid, palmitic acid, and stearic acid
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additional information
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structure-function relationship, overview
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additional information
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the enzyme has a preferance for using branched chain acyl-CoAs as primers and also displays a strong activity towards short or medium chain acyl-CoAs (about C4-C10)
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additional information
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structure-function relationship, overview
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additional information
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enzyme substrate specificity, overview
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