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2.3.1.176: propanoyl-CoA C-acyltransferase

This is an abbreviated version!
For detailed information about propanoyl-CoA C-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.176

Reaction

3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA
+
propanoyl-CoA
=
CoA
 +
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA

Synonyms

3-oxopristanoyl-CoA hydrolase, 3-oxopristanoyl-CoA thiolase, EC 2.3.1.154, HaSCP-2, MsSCP-x/SCP-2 protein, non-specific lipid transfer protein, nsLTP, oxopristanoyl-CoA thiolase, peroxisomal 3-oxoacyl coenzyme A thiolase, peroxisomal thiolase 2, peroxisome sterol carrier protein thiolase, propanoyl-CoA C-acyltransferase, PTE-2, SCP-2, SCP-2/thiolase, SCP-x, Scp2, SCP2L2, SCPc, SCPx, sterol carrier protein 2-like 2, sterol carrier protein 2/3-oxoacyl-CoA thiolase, sterol carrier protein type 2, sterol carrier protein x, sterol carrier protein-2, sterol carrier protein-c, sterol carrier protein-x, sterol carrier protein-x/sterol carrier protein-2, TgSCP2, UMAG_11938

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.176 propanoyl-CoA C-acyltransferase

Application

Application on EC 2.3.1.176 - propanoyl-CoA C-acyltransferase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
agriculture
sterol carrier protein-2 is a validated target for development of novel insecticides due to its divergent protein structure and function from the vertebrate SCP-2. HaSCP-2 is important for normal development and fertility in Helicoverpa armigera. Chemical inhibitors of HaSCP-2 through a structure-based virtual screening are discovered. Bioassay indicates that H1 (N2,N7-di(1-naphthyl)-9H-2,7-fluorenedisulfonamide) and H14 (2,2'-diphenyl-4H,4'H-[6,6'-bibenzo[d][1,3]oxazine]-4,4'-dione) have inhibitory effect on the growth of Helicoverpa armigera larvae. H1 and H14 are promising as useful lead compounds for further optimization and development of novel SCP-2-specific pesticides
drug development
targeting insect SCP-2 may be a viable approach for the development of insecticides
medicine
nutrition
wild-type mice fed a cholesterol-rich diet show increased weight gain, hepatic lipid, and bileacid accumulation. SCP-2 overexpression further exacerbates hepatic lipid accumulation in cholesterol-fed females and males. Primarily in female mice, hepatic cholesterol accumulation induced by SCP-2 overexpression is associated with increased levels of LDL receptor, HDL-receptor scavenger receptor SR-B1, liver fatty acid binding protein L-FABP, and 3alpha-hydroxysteroid dehydrogenase, without alteration of other proteins involved in cholesterol uptake, esterification, efflux, or oxidation/transport of bile salts. The effects of SCP-2 overexpression and cholesterol-rich diet are downregulation of proteins involved in cholesterol transport like L-FABP and SR-B1, cholesterolsynthesis related to sterol regulatory element binding protein 2 and HMG-CoA reductase, and bile acid oxidation/transport
pharmacology
-
although SCP-2 was established as a protein that transfers cholesterol and phospholipids decades ago, recent findings with lipid rafts/caveolae and SCP-2 suggest that they may provide a conceptual link to metabolic processes that might be regulated through the respective signaling pathways