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2.3.1.164: isopenicillin-N N-acyltransferase

This is an abbreviated version!
For detailed information about isopenicillin-N N-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.164

Reaction

phenylacetyl-CoA
+
isopenicillin N
+
H2O
=
CoA
+
penicillin G
+
L-2-aminohexanedioate

Synonyms

6-aminopenicillanate acyltransferase, 6-aminopenicillanic acid acyltransferase, 6-aminopenicillinanic acid phenylacetyltransferase, 6-aminopenicillinanic acylase, aatA, aatB, acyl coA:isopenicillin N-acyltransferase, acyl coenzyme A: isopenicillin N acyltransferase, acyl coenzyme A:6-aminopenicillanic acid acyltransferase, acyl-CoA:6-aminopenicillanate acyltransferase, acyl-CoA:6-APA acyltransferase, acyl-CoA:isopenicillin N acyltransferase, acyl-coenzyme A: IPN acyltransferase, acyl-coenzyme A:isopenicillin N acyltransferase, acyl-coenzyme A:isopenicillin N-acyltransferase, acyltransferase, 6-aminopenicillanate, IAT, IPN acyltransferase, isopenicillin N acyltransferase, isopenicillin N:acyl CoA acyltransferase, isopenicillin N:acyl-CoA: acyltransferase, isopenicillin-N N-acyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.164 isopenicillin-N N-acyltransferase

Expression

Expression on EC 2.3.1.164 - isopenicillin-N N-acyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
addition of either 1,3-diaminopropane or spermidine leads to a rearrangement of the proteome resulting in an overrepresentation of enzymes involved in the biosynthesis of valine and other precursors (e.g. coenzyme A) of penicillin and to the overrepresentation of the last enzyme of the penicillin pathway, isopenicillin N acyltransferase
in strains overexpressing the genes encoding glyoxalase I and II, the protein levels of isopenicillin N synthase and isopenicillin N acyltransferase are increased
investigation of the intracellular proteomes of the Penicillium chrysogenum throughout pilot and industrial processes. The level of IPN acyltransferase at 80 h during the industrial process is around 2fold of that during the pilot process, indicating that the industrial process with a higher penicillin production per cell might provide available environments to induce overexpression of IPN acyltransferase and accelerate penicillin formation
transcription factor AnBH1 acting as a repressor of aatA and aatB expression
-
transcription factor AnCF acting as an activator of aatA and aatB expression
-