2.3.1.159: acridone synthase
This is an abbreviated version!
For detailed information about acridone synthase, go to the full flat file.
Word Map on EC 2.3.1.159
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2.3.1.159
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chalcone
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polyketide
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graveolens
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malonyl-coas
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synthases
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starter
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benzophenone
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rutaceae
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4-coumaroyl-coa
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citrus
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condensations
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phloroglucinols
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stilbene
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tetraketides
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bibenzyl
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anthranilate
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quinolone
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plant-specific
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2-pyrone
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serrata
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huperzia
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moss
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club
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naringenin
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microcarpa
- 2.3.1.159
- chalcone
- polyketide
- graveolens
- malonyl-coas
- synthases
-
starter
- benzophenone
- rutaceae
- 4-coumaroyl-coa
-
citrus
-
condensations
- phloroglucinols
- stilbene
-
tetraketides
-
bibenzyl
- anthranilate
-
quinolone
-
plant-specific
-
2-pyrone
- serrata
- huperzia
-
moss
-
club
- naringenin
- microcarpa
Reaction
3 malonyl-CoA + = 4 CoA + + 3 CO2 +
Synonyms
acridone synthase, ACS, ACS2, PKS1, synthatase, acridone (9Cl)
ECTree
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Reaction
Reaction on EC 2.3.1.159 - acridone synthase
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3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 + H2O
two-step mechanism
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3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 + H2O
Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases
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3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 + H2O
the starter substrates for chalcone synthase or acridone synthase reaction are placed in different topographies in the active site pocket of the enzymes. Therefore conformational changes in the periphery beyond the active site cavity volumes determine the product formation and interconversion of enzymes by mutation of the active sites is insufficient
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