2.3.1.157: glucosamine-1-phosphate N-acetyltransferase

This is an abbreviated version!
For detailed information about glucosamine-1-phosphate N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

amino-sugar-1-P AcTase, amino-sugar-1-phosphate acetyltransferase, bifunctional GlmU protein, bifunctional N-acetyltransferase/uridylyltransferase, bifunctional protein GlmU, bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase, galactosamine-1-phosphate acetyltransferase, GalN-1-P AcTase, GlcN-1-P acetyltransferase, GlcN-1-P AcTase, GlcNAc-1-P uridyltransferase, GlmU, GlmU acetyltransferase, GlmU enzyme, GlmU uridyltransferase, glucosamine 1-phosphate N-acetyltransferase/N-acetylglucosamine-1-phosphate uridyltransferase, glucosamine-1-phosphate acetyltransferase, glucosamine-1-phosphate acetyltransferase/N-acetylglucosamine-1-phosphate uridyltransferase, More, MtbGlmU, MtGlmU, N-acetylglucosamine-1-phosphate pyrophosphorylase, N-acetylglucosamine-1-phosphate uridyltransferase, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase, N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase, Rv1018c, Rxn-1, ST0452, ST0452 protein, STK_04520, UDP-GlcNAc pyrophosphorylase, UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.157 glucosamine-1-phosphate N-acetyltransferase

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Results	in table
3	Activating Compound
29597	AA Sequence
23	Application
2	CAS Registry Number
33	Cloned(Commentary)
12	Cofactor
20	Crystallization (Commentary)
61	General Information
2	General Stability
271	IC50 Value
323	Inhibitors
34	kcat/KM [mM/s]
12	Ki Value [mM]
95	KM Value [mM]
16	Metals/Ions
7	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
255	Organism
6	Pathway
41	PDB ID
30	pH Optimum
1	pH Range
2	Posttranslational Modification
82	Protein Variants
27	Purification (Commentary)
11	Reaction
1	Reaction Type
95	Reference
20	Specific Activity [micromol/min/mg]
132	Substrates and Products (Substrate)
27	Subunits
159	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
41	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.3.1.157 - glucosamine-1-phosphate N-acetyltransferase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0004 - 0.0059

(1R,2R)-2-[[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

3 entries

0.00038 - 0.00784

(1R,2R)-2-[[4-hydroxy-2-methoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

3 entries

0.00001 - 0.0053

(1R,2R)-2-[[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

3 entries

0.00003 - 0.0303

(1R,2R)-2-[[5-(acridin-10(9H)-ylsulfonyl)-4-hydroxy-2-methoxyphenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

3 entries

0.0005 - 0.2

(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid

4 entries

0.00001

(2E)-4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobut-2-enoic acid

Escherichia coli

P0ACC7

pH 7.6, 30°C, recombinant His6-tagged enzyme

736058

0.099

(4Z)-4-(4-benzyloxybenzylidene)-2-(naphthalen-2-yl)-1,3-oxazol-5(4H)-one

Mycobacterium tuberculosis

P9WMN3

30°C, pH not specified in the publication

737150

0.02105 - 0.1

(5-[(E)-[(2,5-dimethylphenyl)imino]methyl]furan-2-yl)(hydroxy)oxoammonium

2 entries

0.01413 - 0.02212

(5E)-1-(3,5-dimethylphenyl)-5-(furan-2-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

2 entries

0.018 - 0.0425

(5Z)-2-imino-5-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]-1,3-thiazolidin-4-one

3 entries

0.00372 - 0.00614

(5Z)-5-(furan-3-ylmethylidene)-1-(4-methoxyphenyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

2 entries

0.0211 - 0.1

(E)-N-(2,5-dimethylphenyl)-1-(5-nitrofuran-2-yl)methanimine

2 entries

0.0041 - 0.0661

(E)-N-(2-fluoro-5-nitrophenyl)-1-(5-nitrofuran-2-yl)methanimine

2 entries

0.0005 - 0.05

1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid

4 entries

0.0009 - 0.015

2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid

3 entries

0.00067 - 0.01

2-(2-cyanopyridin-4-yl)-N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]acetamide

3 entries

0.002 - 0.2

2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate

4 entries

0.0249 - 0.048

3-fluoro-N-[1-(2-methylpropanoyl)-1,2,3,4-tetrahydroquinolin-6-yl]benzene-1-sulfonamide

2 entries

0.0249 - 0.0485

3-fluoro-N-[1-(2-methylpropanoyl)-1,2,3,4-tetrahydroquinolin-6-yl]benzenesulfonamide

2 entries

0.00376 - 0.1

3-hydrazinylquinoline-2-thiol

4 entries

0.00009 - 0.2

4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

4 entries

0.00004 - 0.0084

4-([2,4-dimethoxy-5-[naphthalen-2-yl(phenyl)sulfamoyl]phenyl]amino)-4-oxobutanoic acid

3 entries

0.000058 - 0.2

4-([4-hydroxy-2-methoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

4 entries

0.000018 - 0.2

4-([5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

7 entries

0.00004 - 0.048

4-([5-[bis(4-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

3 entries

0.003 - 0.2

4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid

4 entries

0.00025 - 0.2

4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid

4 entries

0.2

4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid

4 entries

0.0322 - 0.065

4-[[(2,6-dimethoxybenzoyl)oxy]imino]cyclohexa-2,5-dien-1-one

3 entries

0.00009 - 0.0369

4-[[2,4-dimethoxy-5-(10H-phenothiazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

3 entries

0.000007 - 0.2

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

9 entries

0.00005 - 0.0466

4-[[4-hydroxy-2-methoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

3 entries

0.00003 - 0.055

4-[[5-(dibenzo[b,f][1,4]oxazepin-10(11H)-ylsulfonyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

3 entries

0.00004 - 0.0255

4-[[5-(diphenylsulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

3 entries

0.0004 - 0.01

4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

4 entries

0.003 - 0.2

4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

4 entries

0.0014 - 0.0799

5,7-dichloro-2-hydrazinylquinolin-8-ol

5 entries

1

butanoyl-CoA

Mycobacterium tuberculosis

A5U161

pH 7.5, 30°C

756049

0.3

CoA

Mycobacterium tuberculosis

A5U161

pH 7.5, 30°C

756049

1

crotonyl-CoA

Mycobacterium tuberculosis

A5U161

pH 7.5, 30°C

756049

120

D-galactosamine 1-phosphate

Mycobacterium tuberculosis

A5U161

pH 7.5, 30°C

756049

10

D-glucosamine 6-phosphate

Mycobacterium tuberculosis

A5U161

pH 7.5, 30°C

756049

5

D-glucose 1-phosphate

Mycobacterium tuberculosis

A5U161

pH 7.5, 30°C

756049

0.0137

dicumarol

Mycobacterium tuberculosis

A5U161

pH 7.5, 37°C

756779

2

isobutanoyl-CoA

Mycobacterium tuberculosis

A5U161

pH 7.5, 30°C

756049

2

malonyl-CoA

Mycobacterium tuberculosis

A5U161

pH 7.5, 30°C

756049

0.015 - 0.2

methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate

4 entries

0.11 - 0.2

N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide

4 entries

0.0005 - 0.2

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine

4 entries

0.0005 - 0.2

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine

4 entries

0.00052 - 0.009

N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]-2-(2-fluoropyridin-4-yl)acetamide

3 entries

0.00043 - 0.0247

N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]-3-(2H-tetrazol-5-yl)propanamide

3 entries

0.54

N-[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]-2-(pyridin-4-yl)acetamide

Escherichia coli

P0ACC7

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.00054

N-[2,4-dimethoxy-5-(10H-phenoxazine-10-sulfonyl)phenyl]-2-(pyridin-4-yl)acetamide

Escherichia coli

-

pH 7.3, 37°C

755865

0.02 - 0.2

N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide

4 entries

0.08 - 0.2

N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide

4 entries

0.01 - 0.54

N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide

4 entries

0.002 - 0.2

N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide

4 entries

0.001 - 0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide

4 entries

0.0015 - 0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide

8 entries

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide

4 entries

0.1 - 0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide

4 entries

0.2

N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide

4 entries

0.017 - 0.2

N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide

4 entries

0.021 - 0.2

N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide

4 entries

0.003 - 0.2

N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide

8 entries

0.002 - 0.2

N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide

4 entries

0.00003 - 0.0099

N-[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]-2-(2-fluoropyridin-4-yl)acetamide

3 entries

0.00003 - 0.032

N-[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]-2-(pyridin-4-yl)acetamide

3 entries

0.2

N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide

4 entries

0.04 - 0.2

N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide

4 entries

0.2

N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

4 entries

0.004 - 0.2

N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

4 entries

0.005 - 0.2

N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

4 entries

0.015 - 0.2

N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

4 entries

0.025 - 0.2

N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

4 entries

0.13 - 0.2

N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

4 entries

0.015 - 0.2

N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

4 entries

0.0442 - 0.09756

terreic acid

4 entries

0.0002 - 0.2

[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid

3 entries

0.00405 - 0.066

[4-fluoro-3-[(E)-([5-[hydroxy(oxo)azaniumyl]furan-2-yl]methylidene)amino]phenyl](hydroxy)oxoammonium

2 entries

0.0001 - 0.2

[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid

4 entries

0.0004

(1R,2R)-2-[[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.00051

(1R,2R)-2-[[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.0059

(1R,2R)-2-[[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.00038

(1R,2R)-2-[[4-hydroxy-2-methoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.00048

(1R,2R)-2-[[4-hydroxy-2-methoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.00784

(1R,2R)-2-[[4-hydroxy-2-methoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.00001

(1R,2R)-2-[[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.00003

(1R,2R)-2-[[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.0053

(1R,2R)-2-[[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.00003

(1R,2R)-2-[[5-(acridin-10(9H)-ylsulfonyl)-4-hydroxy-2-methoxyphenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.00006

(1R,2R)-2-[[5-(acridin-10(9H)-ylsulfonyl)-4-hydroxy-2-methoxyphenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.0303

(1R,2R)-2-[[5-(acridin-10(9H)-ylsulfonyl)-4-hydroxy-2-methoxyphenyl]carbamoyl]-3-methylcyclopropanecarboxylic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.0005

(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.002

(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.01

(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.2

(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.02105

(5-[(E)-[(2,5-dimethylphenyl)imino]methyl]furan-2-yl)(hydroxy)oxoammonium

Escherichia coli

-

pH 7.3, 37°C

755865

0.1

(5-[(E)-[(2,5-dimethylphenyl)imino]methyl]furan-2-yl)(hydroxy)oxoammonium

Haemophilus influenzae

-

pH 7.3, 37°C

755865

0.01413

(5E)-1-(3,5-dimethylphenyl)-5-(furan-2-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Mycobacterium tuberculosis

P9WMN3

versus acetyl-CoA, pH 7.5, 37°C, recombinant enzyme

737291

0.02212

(5E)-1-(3,5-dimethylphenyl)-5-(furan-2-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Mycobacterium tuberculosis

P9WMN3

versus alpha-D-glucosamine 1-phosphate, pH 7.5, 37°C, recombinant enzyme

737291

0.018

(5Z)-2-imino-5-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]-1,3-thiazolidin-4-one

Mycobacterium tuberculosis

P9WMN3

pH not specified in the publication, temperature not specified in the publication

737291

0.0318

(5Z)-2-imino-5-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]-1,3-thiazolidin-4-one

Mycobacterium tuberculosis

P9WMN3

versus acetyl-CoA, pH 7.5, 37°C, recombinant enzyme

737291

0.0425

(5Z)-2-imino-5-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]-1,3-thiazolidin-4-one

Mycobacterium tuberculosis

P9WMN3

versus alpha-D-glucosamine 1-phosphate, pH 7.5, 37°C, recombinant enzyme

737291

0.00372

(5Z)-5-(furan-3-ylmethylidene)-1-(4-methoxyphenyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Mycobacterium tuberculosis

P9WMN3

versus acetyl-CoA, pH 7.5, 37°C, recombinant enzyme

737291

0.00614

(5Z)-5-(furan-3-ylmethylidene)-1-(4-methoxyphenyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Mycobacterium tuberculosis

P9WMN3

versus alpha-D-glucosamine 1-phosphate, pH 7.5, 37°C, recombinant enzyme

737291

0.0211

(E)-N-(2,5-dimethylphenyl)-1-(5-nitrofuran-2-yl)methanimine

Escherichia coli

P0ACC7

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.1

(E)-N-(2,5-dimethylphenyl)-1-(5-nitrofuran-2-yl)methanimine

Haemophilus influenzae

P43889

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.0041

(E)-N-(2-fluoro-5-nitrophenyl)-1-(5-nitrofuran-2-yl)methanimine

Escherichia coli

P0ACC7

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.0661

(E)-N-(2-fluoro-5-nitrophenyl)-1-(5-nitrofuran-2-yl)methanimine

Haemophilus influenzae

P43889

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.0005

1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.001

1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.002

1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.05

1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid

Staphylococcus aureus

-

pH 7.35, 22°C

719064

0.0009

2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.005

2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.015

2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.00067

2-(2-cyanopyridin-4-yl)-N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]acetamide

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.00068

2-(2-cyanopyridin-4-yl)-N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]acetamide

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.01

2-(2-cyanopyridin-4-yl)-N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]acetamide

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.002

2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.002

2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate

Escherichia coli

-

pH 7.35, 22°C

719064

0.09

2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.2

2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.0249

3-fluoro-N-[1-(2-methylpropanoyl)-1,2,3,4-tetrahydroquinolin-6-yl]benzene-1-sulfonamide

Escherichia coli

-

pH 7.3, 37°C

755865

0.048

3-fluoro-N-[1-(2-methylpropanoyl)-1,2,3,4-tetrahydroquinolin-6-yl]benzene-1-sulfonamide

Haemophilus influenzae

-

pH 7.3, 37°C

755865

0.0249

3-fluoro-N-[1-(2-methylpropanoyl)-1,2,3,4-tetrahydroquinolin-6-yl]benzenesulfonamide

Escherichia coli

P0ACC7

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.0485

3-fluoro-N-[1-(2-methylpropanoyl)-1,2,3,4-tetrahydroquinolin-6-yl]benzenesulfonamide

Haemophilus influenzae

P43889

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.00376

3-hydrazinylquinoline-2-thiol

Escherichia coli

-

pH 7.3, 37°C

755865

0.0038

3-hydrazinylquinoline-2-thiol

Escherichia coli

P0ACC7

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.1

3-hydrazinylquinoline-2-thiol

Haemophilus influenzae

-

pH 7.3, 37°C

755865

0.1

3-hydrazinylquinoline-2-thiol

Haemophilus influenzae

P43889

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.00009

4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.0006

4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.02

4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.2

4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.00004

4-([2,4-dimethoxy-5-[naphthalen-2-yl(phenyl)sulfamoyl]phenyl]amino)-4-oxobutanoic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.00083

4-([2,4-dimethoxy-5-[naphthalen-2-yl(phenyl)sulfamoyl]phenyl]amino)-4-oxobutanoic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.0084

4-([2,4-dimethoxy-5-[naphthalen-2-yl(phenyl)sulfamoyl]phenyl]amino)-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.000058

4-([4-hydroxy-2-methoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

Escherichia coli

-

pH 7.2, temperature not specified in the publication

719986

0.00028

4-([4-hydroxy-2-methoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

Haemophilus influenzae

-

pH 7.2, temperature not specified in the publication

719986

0.0047

4-([4-hydroxy-2-methoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH 7.2, temperature not specified in the publication

719986

0.2

4-([4-hydroxy-2-methoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid

Staphylococcus aureus

-

above, pH 7.2, temperature not specified in the publication

719986

0.000018

4-([5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Escherichia coli

-

pH 7.2, temperature not specified in the publication

719986

0.00002

4-([5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.0004

4-([5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.0004

4-([5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Haemophilus influenzae

-

pH 7.2, temperature not specified in the publication

719986

0.04

4-([5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH 7.2, temperature not specified in the publication

719986

0.0402

4-([5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.2

4-([5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Staphylococcus aureus

-

above, pH 7.2, temperature not specified in the publication

719986

0.00004

4-([5-[bis(4-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.00032

4-([5-[bis(4-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.048

4-([5-[bis(4-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]amino)-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.003

4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.005

4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.012

4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.2

4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.00025

4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.0005

4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.0005

4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.2

4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid

Haemophilus influenzae

-

above, pH 7.35, 22°C

719064

0.2

4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid

Escherichia coli

-

above, pH 7.35, 22°C

719064

0.2

4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.0322

4-[[(2,6-dimethoxybenzoyl)oxy]imino]cyclohexa-2,5-dien-1-one

Mycobacterium tuberculosis

P9WMN3

versus alpha-D-glucosamine 1-phosphate, pH 7.5, 37°C, recombinant enzyme

737291

0.0533

4-[[(2,6-dimethoxybenzoyl)oxy]imino]cyclohexa-2,5-dien-1-one

Mycobacterium tuberculosis

P9WMN3

versus acetyl-CoA, pH 7.5, 37°C, recombinant enzyme

737291

0.065

4-[[(2,6-dimethoxybenzoyl)oxy]imino]cyclohexa-2,5-dien-1-one

Mycobacterium tuberculosis

P9WMN3

pH not specified in the publication, temperature not specified in the publication

737291

0.00009

4-[[2,4-dimethoxy-5-(10H-phenothiazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.00037

4-[[2,4-dimethoxy-5-(10H-phenothiazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.0369

4-[[2,4-dimethoxy-5-(10H-phenothiazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.000007

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Escherichia coli

-

pH 7.2, temperature not specified in the publication

719986

0.00001

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.00001

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Escherichia coli

P0ACC7

pH 7.6, 30°C, recombinant His6-tagged enzyme

736058

0.00002

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.000023

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH 7.2, temperature not specified in the publication

719986

0.0146

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.015

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH 7.2, temperature not specified in the publication

719986

0.0215

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.2

4-[[2,4-dimethoxy-5-(10H-phenoxazin-10-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Staphylococcus aureus

-

above, pH 7.2, temperature not specified in the publication

719986

0.00005

4-[[4-hydroxy-2-methoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.00028

4-[[4-hydroxy-2-methoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.0466

4-[[4-hydroxy-2-methoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.00003

4-[[5-(dibenzo[b,f][1,4]oxazepin-10(11H)-ylsulfonyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.00008

4-[[5-(dibenzo[b,f][1,4]oxazepin-10(11H)-ylsulfonyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.055

4-[[5-(dibenzo[b,f][1,4]oxazepin-10(11H)-ylsulfonyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.00004

4-[[5-(diphenylsulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.00091

4-[[5-(diphenylsulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.0255

4-[[5-(diphenylsulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.0004

4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.002

4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.003

4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.01

4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Staphylococcus aureus

-

pH 7.35, 22°C

719064

0.003

4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.005

4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.006

4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.0014

5,7-dichloro-2-hydrazinylquinolin-8-ol

Escherichia coli

-

pH 7.3, 37°C

755865

0.0014

5,7-dichloro-2-hydrazinylquinolin-8-ol

Escherichia coli

P0ACC7

pH not specified in the publication, temperature not specified in the publication

735518

0.0014

5,7-dichloro-2-hydrazinylquinolin-8-ol

Escherichia coli

P0ACC7

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.079

5,7-dichloro-2-hydrazinylquinolin-8-ol

Haemophilus influenzae

-

pH 7.3, 37°C

755865

0.0799

5,7-dichloro-2-hydrazinylquinolin-8-ol

Haemophilus influenzae

P43889

pH 7.6, 30°C, recombinant His6-tagged enzyme

735518

0.015

methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate

Escherichia coli

-

pH 7.35, 22°C

719064

0.055

methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.11

N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.12

N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide

Escherichia coli

-

above, pH 7.35, 22°C

719064

0.0005

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine

Escherichia coli

-

pH 7.35, 22°C

719064

0.001

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.03

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.2

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.0005

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine

Escherichia coli

-

pH 7.35, 22°C

719064

0.005

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.02

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.2

N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.00052

N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]-2-(2-fluoropyridin-4-yl)acetamide

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.0008

N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]-2-(2-fluoropyridin-4-yl)acetamide

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.009

N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]-2-(2-fluoropyridin-4-yl)acetamide

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.00043

N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]-3-(2H-tetrazol-5-yl)propanamide

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.0006

N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]-3-(2H-tetrazol-5-yl)propanamide

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.0247

N-[2,4-dimethoxy-5-(1,2,3,4-tetrahydroquinolin-2-ylsulfonyl)phenyl]-3-(2H-tetrazol-5-yl)propanamide

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.02

N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.07

N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.08

N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide

Haemophilus influenzae

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.01

N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.54

N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.002

N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.008

N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.001

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.006

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.0015

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.0021

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide

Escherichia coli

-

pH 7.2, temperature not specified in the publication

719986

0.003

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.0078

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide

Haemophilus influenzae

-

pH 7.2, temperature not specified in the publication

719986

0.055

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.2, temperature not specified in the publication

719986

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.2, temperature not specified in the publication

719986

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide

Haemophilus influenzae

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide

Escherichia coli

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.1

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide

Haemophilus influenzae

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide

Haemophilus influenzae

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.017

N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.04

N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.021

N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.047

N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.003

N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.0033

N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide

Escherichia coli

-

pH 7.2, temperature not specified in the publication

719986

0.006

N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.0064

N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide

Haemophilus influenzae

-

pH 7.2, temperature not specified in the publication

719986

0.2

N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.2, temperature not specified in the publication

719986

0.2

N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.2, temperature not specified in the publication

719986

0.2

N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.002

N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.016

N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.00003

N-[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]-2-(2-fluoropyridin-4-yl)acetamide

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.00009

N-[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]-2-(2-fluoropyridin-4-yl)acetamide

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.0099

N-[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]-2-(2-fluoropyridin-4-yl)acetamide

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.00003

N-[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]-2-(pyridin-4-yl)acetamide

Haemophilus influenzae

-

pH and temperature not specified in the publication

719070

0.00006

N-[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]-2-(pyridin-4-yl)acetamide

Escherichia coli

-

pH and temperature not specified in the publication

719070

0.032

N-[5-(acridin-10(9H)-ylsulfonyl)-2,4-dimethoxyphenyl]-2-(pyridin-4-yl)acetamide

Streptococcus pneumoniae

-

pH and temperature not specified in the publication

719070

0.2

N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide

Haemophilus influenzae

-

above, pH 7.35, 22°C

719064

0.2

N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide

Escherichia coli

-

above, pH 7.35, 22°C

719064

0.2

N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.04

N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.07

N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide

Streptococcus pneumoniae

-

pH 7.35, 22°C

719064

0.08

N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Haemophilus influenzae

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Escherichia coli

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.004

N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.02

N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.005

N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.01

N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.015

N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.03

N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.025

N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.06

N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.13

N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.2

N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Haemophilus influenzae

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.015

N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Escherichia coli

-

pH 7.35, 22°C

719064

0.08

N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064

0.0442

terreic acid

Escherichia coli

P0ACC7

pH 7.3, 37°C

736517

0.04424

terreic acid

Escherichia coli

P0ACC7

pH 7.6, 37°C

736517

0.04424

terreic acid

Escherichia coli

P0ACC7

pH 7.6, 30°C, recombinant enzyme

761532

0.09756

terreic acid

Haemophilus influenzae

-

pH 7.6, 30°C

761532

0.0002

[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.0003

[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.00405

[4-fluoro-3-[(E)-([5-[hydroxy(oxo)azaniumyl]furan-2-yl]methylidene)amino]phenyl](hydroxy)oxoammonium

Escherichia coli

-

pH 7.3, 37°C

755865

0.066

[4-fluoro-3-[(E)-([5-[hydroxy(oxo)azaniumyl]furan-2-yl]methylidene)amino]phenyl](hydroxy)oxoammonium

Haemophilus influenzae

-

pH 7.3, 37°C

755865

0.0001

[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid

Escherichia coli

-

pH 7.35, 22°C

719064

0.0002

[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid

Haemophilus influenzae

-

pH 7.35, 22°C

719064

0.2

[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid

Staphylococcus aureus

-

above, pH 7.35, 22°C

719064

0.2

[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid

Streptococcus pneumoniae

-

above, pH 7.35, 22°C

719064