2.3.1.149: Platelet-activating factor acetyltransferase
This is an abbreviated version!
For detailed information about Platelet-activating factor acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.149
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2.3.1.149
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lipoprotein
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paf-acetylhydrolase
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phospholipase
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hdl
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atherosclerosis
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low-density
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hdl-associated
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lipoprotein-associated
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paraoxonase
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paf-like
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atherogenic
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lyso-paf
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lissencephaly
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antiatherogenic
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lis1
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normolipidemic
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pla2g7
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paf-induced
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paf-receptor
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cholinephosphotransferase
- 2.3.1.149
- lipoprotein
- paf-acetylhydrolase
- phospholipase
- hdl
- atherosclerosis
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low-density
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hdl-associated
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lipoprotein-associated
- paraoxonase
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paf-like
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atherogenic
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lyso-paf
- lissencephaly
-
antiatherogenic
- lis1
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normolipidemic
- pla2g7
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paf-induced
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paf-receptor
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cholinephosphotransferase
Reaction
Synonyms
PAF acetyltransferase, PAF-AH, PAF: acyllyso-GPC transacetylase, platelet-activating factor transacetylase, platelet-activating factor-acetylhydrolase, plateletactivating factor-specific acetylhydrolase
ECTree
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Substrates Products
Substrates Products on EC 2.3.1.149 - Platelet-activating factor acetyltransferase
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REACTION DIAGRAM
1-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid
1-organyl-sn-glycero-3-phosphocholine + 1-acyl-2-lyso-sn-glycero-3-phospholipid
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1-acyl-sn-glycero-3-phosphocholine is termed lyso-PC
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?
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphate
?
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?
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphoinositol
?
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?
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphoserine
?
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?
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + alkyllyso-sn-glycero-3-phosphate
?
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?
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + lyso-phosphatidylcholine
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?
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + lysoplasmalogen
1-Alk-1-enyl-2-acetyl-sn-glycero-3-phosphoethanolamine + ?
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1-alkyl-2-acetyl-sn-glycero-3-phosphocholine is platelet-activating factor
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?
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + radyllyso-sn-glycero-3-phosphocholine
?
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?
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + radyllyso-sn-glycero-3-phosphoethanolamine
?
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?
1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid
1-organyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-2-lyso-sn-glycero-3-phospholipid
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1-hexadecanoyl-sn-glycero-3-phosphocholine is termed C16:0 lyso-PC
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?
1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid
1-organyl-sn-glycero-3-phosphocholine + 1-O-alkyl-2-lyso-sn-glycero-3-phospholipid
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1-O-alkyl-sn-glycero-3-phosphocholine is termed lyso-PAF, artificial substrate
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?
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid
1-organyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-lyso-sn-glycero-3-phospholipid
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1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine is termed C16:0 lyso-PAF
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?
Hexadecyl-acetyl-sn-glycero-3-phosphocholine + alk-1-enyllyso-sn-glycero-phosphoethanolamine
?
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?
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ATP regulates the activity of the enzyme by reversible activation and inactivation via the phosphorylation and dephosphorylation cycle
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additional information
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the enzyme may participate in the biosynthesis of ethanolamine plasmalogen and acyl analogs of platelet-activating factor, in vivo, finetuning of platelet-activating factor biological responses and cross-talk between de novo and remodeling pathways of platelet biosynthesis
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additional information
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the enzyme transfers short-chain fatty acids from platelet-activating factor PAF and its close ether- and ester-linked analogues to ether/ester-linked lysophospholipids, enzyme activity distribution within different LDL-subfactions, overview
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additional information
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the enzyme also has a platelet-activating factor acetylhydrolase activity
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?