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2.3.1.149: Platelet-activating factor acetyltransferase

This is an abbreviated version!
For detailed information about Platelet-activating factor acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.149

Reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine
+
1-organyl-2-lyso-sn-glycero-3-phospholipid
=
1-alkyl-2-lyso-sn-glycero-3-phosphocholine
+
1-organyl-2-acetyl-sn-glycero-3-phospholipid

Synonyms

PAF acetyltransferase, PAF-AH, PAF: acyllyso-GPC transacetylase, platelet-activating factor transacetylase, platelet-activating factor-acetylhydrolase, plateletactivating factor-specific acetylhydrolase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.149 Platelet-activating factor acetyltransferase

General Information

General Information on EC 2.3.1.149 - Platelet-activating factor acetyltransferase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
lyso- platelet-activating factor accumulation and an increase in platelet-activating factor bioactivity is observed in the aorta of some patients. In atherogenic aortas, an imbalance between PAF-AH and transacetylase activity, as well as lyso-platelet-activating factor accumulation, may lead to unregulated platelet-activating factor formation and to progression of atherosclerosis