2.3.1.147: glycerophospholipid arachidonoyl-transferase (CoA-independent)
This is an abbreviated version!
For detailed information about glycerophospholipid arachidonoyl-transferase (CoA-independent), go to the full flat file.
Word Map on EC 2.3.1.147
-
2.3.1.147
-
arachidonic
-
phospholipase
-
platelet-activating
-
paf
-
transacylation
-
coa-dependent
-
plasmalogens
-
1-acyl
-
ethanolamine-containing
-
alkylacylglycerophosphocholine
-
arachidonylated
-
arachidonoyl-coa
-
arachidonate-containing
-
alkylacyl-gpc
-
ether-containing
-
3harachidonate
-
aa-containing
-
ionophore-stimulated
-
3hlyso-paf
-
pharmacology
-
medicine
- 2.3.1.147
-
arachidonic
- phospholipase
-
platelet-activating
- paf
-
transacylation
-
coa-dependent
- plasmalogens
-
1-acyl
-
ethanolamine-containing
-
alkylacylglycerophosphocholine
-
arachidonylated
- arachidonoyl-coa
-
arachidonate-containing
-
alkylacyl-gpc
-
ether-containing
-
3harachidonate
-
aa-containing
-
ionophore-stimulated
-
3hlyso-paf
- pharmacology
- medicine
Reaction
Synonyms
Acyltransferase, 1-alkylglycerophosphocholine, CoA-independent transacylase, CoA-IT, CoAIT, Coenzyme A-independent transacylase
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 2.3.1.147 - glycerophospholipid arachidonoyl-transferase (CoA-independent)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
1-Acyl-glycerophosphoethanolamine
?
-
,transfer of 20:4 from diacylglycerophosphocholine
-
-
?
1-Alkenyl-2-lysoglycerophospholipid + 1-acyl-2-arachidonoyl-glycerophosphocholine
1-Alkenyl-2-arachidonyl-glycerophospholipid + 1-acyl-2-lyso-glycerophosphocholine
-
-
-
-
?
1-Alkenyl-2-lysoglycerophospholipid + 1-alkyl-2-arachidonoyl-glycerophosphocholine
1-Alkenyl-2-arachidonoylglycerophospholipid + 1-alkyl-2-lyso-glycerophosphocholine
-
-
-
-
?
1-Alkenyl-glycerophosphoethanolamine + diacylglycerophosphocholine
?
-
transfer of 20:4 from diacylglycerophosphocholine
-
-
?
1-alkyl-2-lyso-glyceryl-3-phosphorylcholine + 1-acyl-2-arachidonoyl-glyceryl-3-phosphorylcholine
1-alkyl-2-arachidonoylglycerophosphocholine + 1-acyl-2-lyso-glycerophosphocholine
-
-
-
-
?
1-Alkyl-2-lysoglycerophospholipid + 1-acyl-2-arachidonoyl-glycerophosphocholine
?
-
-
-
-
?
1-Alkyl-2-lysoglycerophospholipid + 1-alkyl-2-arachidonoyl-glycerophosphocholine
1-Alkyl-2-arachidonoylglycerophospholipid + 1-alkyl-2-lyso-glycerophosphocholine
-
-
-
-
?
1-Alkyl-glycerophosphoethanolamine + diacylglycerophosphocholine
?
-
transfer of 20:4 from diacylglycerophosphocholine
-
-
?
additional information
?
-
-
marginal transacylation with 1-acyl-2-lysoglycerophospholipid
-
-
?
additional information
?
-
-
selectively transfers arachidonate and other long-chain unsaturated fatty acyl groups. Strong preference for phosphocholine-containing glycerophospholipids and phosphoethanolamine-containing glycerophospholipids
-
-
?
additional information
?
-
-
EC 2.3.1.147 and 14000 MW phospholipase A act in a cooperative fashion in the production of platelet-activating factor in inflammatory cells
-
-
?
additional information
?
-
-
inhibition of the enzyme can be linked to blockade of proliferation and the induction of apoptosis in HL-60 cells
-
-
?
additional information
?
-
-
the enzyme mediates the movement of arachidonate into the large pool of 1-ether-linked phospholipids in human neutrophils
-
-
?
additional information
?
-
-
the enzyme is important for the production of inflammatory lipid mediators in stimulated cells
-
-
?
additional information
?
-
-
blockade of the enzyme, which leads to inhibition of arachidonate remodelling between phospholipids, results in the attenuation of platelet-activating factor production, arachidonic acid release and the formation of eicosanoid products
-
-
?
additional information
?
-
-
the enzyme is the key mediator of arachidonate remodeling
-
-
?
additional information
?
-
-
the enzyme is involved in the control of intracellular arachidonic acid levels, enzyme inhibition in cancer cell has an anti-carcinogenic effect and induces accumulation of unesterified arachidonic acid, overview
-
-
?
additional information
?
-
-
the acyl donor is a fatty acid esterified at sn-2 position of diacylphospholipids but not a free fatty acid or an acyl-CoA. Only C20 and C22 polyunsaturated fatty acids are transferred. Both n-6 and n-3 acids can be transferred
-
-
?
additional information
?
-
-
the enzyme is considered to play an important role in the reacylation of ether-containing phospholipids to provide polyunsaturated fatty acid containing ether phospholipids
-
-
?
additional information
?
-
-
key enzyme responsible for the prolonged generation of lyso-platelet-activating factor that increases capability of CoA-independent transacylation followed by CoA-dependent acetylation of lyso-platelet-activating factor, can sustain the biosynthesis of platelet activating factor in lipopolysaccharide-stimulated IC-21 macrophages
-
-
?
additional information
?
-
-
the reaction is extremely important in the remodeling of phospholipid molecular species and the mobilization of arachidonate into ether-linked lipids. The transfer of arachidonate to 1-alkyl-2-lyso-sn-glycero-3-phosphocholine is important in the final inactivation step for platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine), whereby 1-alkyl-2-arachidonoyl-sn-glycerol-3-phosphocholine, a stored precursor of both platelet activating factor and arachidonic acid metabolites is formed
-
-
?