2.3.1.147: glycerophospholipid arachidonoyl-transferase (CoA-independent)
This is an abbreviated version!
For detailed information about glycerophospholipid arachidonoyl-transferase (CoA-independent), go to the full flat file.
Word Map on EC 2.3.1.147
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2.3.1.147
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arachidonic
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phospholipase
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platelet-activating
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paf
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transacylation
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coa-dependent
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plasmalogens
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1-acyl
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ethanolamine-containing
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alkylacylglycerophosphocholine
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arachidonylated
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arachidonoyl-coa
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arachidonate-containing
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alkylacyl-gpc
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ether-containing
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3harachidonate
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aa-containing
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ionophore-stimulated
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3hlyso-paf
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pharmacology
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medicine
- 2.3.1.147
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arachidonic
- phospholipase
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platelet-activating
- paf
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transacylation
-
coa-dependent
- plasmalogens
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1-acyl
-
ethanolamine-containing
-
alkylacylglycerophosphocholine
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arachidonylated
- arachidonoyl-coa
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arachidonate-containing
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alkylacyl-gpc
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ether-containing
-
3harachidonate
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aa-containing
-
ionophore-stimulated
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3hlyso-paf
- pharmacology
- medicine
Reaction
Synonyms
Acyltransferase, 1-alkylglycerophosphocholine, CoA-independent transacylase, CoA-IT, CoAIT, Coenzyme A-independent transacylase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.3.1.147 - glycerophospholipid arachidonoyl-transferase (CoA-independent)
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REACTION DIAGRAM
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EC 2.3.1.147 and 14000 MW phospholipase A act in a cooperative fashion in the production of platelet-activating factor in inflammatory cells
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inhibition of the enzyme can be linked to blockade of proliferation and the induction of apoptosis in HL-60 cells
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the enzyme mediates the movement of arachidonate into the large pool of 1-ether-linked phospholipids in human neutrophils
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the enzyme is important for the production of inflammatory lipid mediators in stimulated cells
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blockade of the enzyme, which leads to inhibition of arachidonate remodelling between phospholipids, results in the attenuation of platelet-activating factor production, arachidonic acid release and the formation of eicosanoid products
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the enzyme is the key mediator of arachidonate remodeling
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the enzyme is involved in the control of intracellular arachidonic acid levels, enzyme inhibition in cancer cell has an anti-carcinogenic effect and induces accumulation of unesterified arachidonic acid, overview
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the enzyme is considered to play an important role in the reacylation of ether-containing phospholipids to provide polyunsaturated fatty acid containing ether phospholipids
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key enzyme responsible for the prolonged generation of lyso-platelet-activating factor that increases capability of CoA-independent transacylation followed by CoA-dependent acetylation of lyso-platelet-activating factor, can sustain the biosynthesis of platelet activating factor in lipopolysaccharide-stimulated IC-21 macrophages
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the reaction is extremely important in the remodeling of phospholipid molecular species and the mobilization of arachidonate into ether-linked lipids. The transfer of arachidonate to 1-alkyl-2-lyso-sn-glycero-3-phosphocholine is important in the final inactivation step for platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine), whereby 1-alkyl-2-arachidonoyl-sn-glycerol-3-phosphocholine, a stored precursor of both platelet activating factor and arachidonic acid metabolites is formed
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