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2.3.1.147: glycerophospholipid arachidonoyl-transferase (CoA-independent)

This is an abbreviated version!
For detailed information about glycerophospholipid arachidonoyl-transferase (CoA-independent), go to the full flat file.

Word Map on EC 2.3.1.147

Reaction

1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine
+
1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine
=
1-organyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
+
1-organyl-2-lyso-sn-glycero-3-phosphocholine

Synonyms

Acyltransferase, 1-alkylglycerophosphocholine, CoA-independent transacylase, CoA-IT, CoAIT, Coenzyme A-independent transacylase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent)

Inhibitors

Inhibitors on EC 2.3.1.147 - glycerophospholipid arachidonoyl-transferase (CoA-independent)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3S,4R)-[4-(Isobutenyloxy)-3-triphenylmethylamino]azetitin-2-one
-
i.e. SB 216754
1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine
-
-
1-[2-[3-(4-Chloro-3-trifluoromethylphenyl)ureido]-4-trifluoromethyl phenoxy]-4,5-dichlorobenzene sulfonic acid
-
i.e. SK&F 45905
4-methoxybenzyl(3S,4R)-6-bromo-6-[(1-methyl-1,2,3-triazol-4-yl)-hydroxymethyl]penicillanate
-
i.e. SB 212047
Diethyl 7-(1,4,5-triphenyl imidazol-2-yloxy)heptane phosphonate
-
SK&F 98628
Diethyl 7-(3,4,5-triphenyl-2-oxo-2,3-dihydro-imidazol-1-yl)heptane-phosphonate
-
i.e. SK&F 98625
diethyl dicarbonate
-
-
N-tosyl-L-phenylalanine chloromethyl ketone
-
-
NS-398
-
enzyme inhibition in cancer cell has an anti-carcinogenic effect and induces accumulation of unesterified arachidonic acid
Phenylmethyl-sulfonyl fluoride
-
-
PLT-98625
-
enzyme inhibition in cancer cell has an anti-carcinogenic effect and induces accumulation of unesterified arachidonic acid
SB-98625
-
i.e. SKF 98625 or diethyl-7-(3,4,5-triphenyl-2-oxo-2,3-dihydroimidazol-1-yl)hepatine phosphate, inhibitor blocks the replication of MDA-MB-231 cells in early to mid G1 phase, induces early rounding and occasional blebbing of the cells, but not late apoptosis, blistering, and lysis
SKF 98625
-
a reversible antagonist of CoA-IT, in vitro and in vivo inhibition, induces eosinophil apoptosis in vitro
Triacsin C
-
enzyme inhibition in cancer cell has an anti-carcinogenic effect and induces accumulation of unesterified arachidonic acid
additional information
-
inhibition of the enzyme attenuates the proliferation of breast cancer cell lines, intracellular level and distribution of free or triglyceride arachidonic acid, or an oxidized metabolite thereof, and blockage of remodeling are responsible for the effect, overview
-