2.3.1.147: glycerophospholipid arachidonoyl-transferase (CoA-independent)

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For detailed information about glycerophospholipid arachidonoyl-transferase (CoA-independent), go to the full flat file.

Word Map on EC 2.3.1.147

2.3.1.147

arachidonic

phospholipase

platelet-activating

paf

transacylation

coa-dependent

plasmalogens

1-acyl

ethanolamine-containing

alkylacylglycerophosphocholine

arachidonylated

arachidonoyl-coa

arachidonate-containing

alkylacyl-gpc

ether-containing

3harachidonate

aa-containing

ionophore-stimulated

3hlyso-paf

pharmacology

medicine

Reaction

1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine

1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine

1-organyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine

1-organyl-2-lyso-sn-glycero-3-phosphocholine

Synonyms

Acyltransferase, 1-alkylglycerophosphocholine, CoA-independent transacylase, CoA-IT, CoAIT, Coenzyme A-independent transacylase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent)

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Results	in table
2	Activating Compound
2	Application
1	CAS Registry Number
24	Disease/ Diagnostics
3	General Information
2	IC50 Value
21	Inhibitors
1	Ki Value [mM]
1	KM Value [mM]
3	Localization
11	Natural Substrates/ Products (Substrates)
16	Organism
3	pH Optimum
2	Reaction
1	Reaction Type
16	Reference
26	Source Tissue
27	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Disease

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Disease on EC 2.3.1.147 - glycerophospholipid arachidonoyl-transferase (CoA-independent)

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Asthma

Regulation of Arachidonate Remodeling Enzymes Impacts Eosinophil Survival During Allergic Asthma.

19151322

Breast Neoplasms

Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells.

10626809

Endotoxemia

Dietary alpha-linolenate suppresses endotoxin-induced platelet-activating factor production in rat kidney.

10188594

Hyperinsulinism

Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney.

9101420

Joint Diseases

Biochemical and pharmacological comparison of a cytosolic, high molecular weight phospholipase A2, human synovial fluid phospholipase A2 and CoA-independent transacylase.

7812680

Leukemia

Inhibitors of coenzyme A-independent transacylase induce apoptosis in human HL-60 cells.

8930205

Mastocytoma

Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids.

1740420

Neoplasms

CoA-independent transacylase activity is increased in human neutrophils after treatment with tumor necrosis factor alpha.

7947995

Inhibition of tumor necrosis factor-alpha production by SK&F 98625, a CoA-independent transacylase inhibitor, in cultured rat peritoneal macrophages.

9600332

The activities of monocyte lysophosphatidylcholine acyltransferase and coenzyme A-independent transacylase are changed by the inflammatory cytokines tumor necrosis factor alpha and interferon gamma.

15863370